Vaccines and immunotherapies for the prevention of infectious diseases having cutaneous manifestations

Wu, Jashin J.; Huang, David B.; Pang, Katie R.; Tyring, Stephen K.

doi:10.1016/j.jaad.2003.12.003

Cited by 21 publications

(8 citation statements)

References 298 publications

(243 reference statements)

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“…The two new vaccines are currently being studied for evidence of improved reactivity if a more extensive vaccination program is needed. 3 The vaccination is performed by intraepidermal introduction of vaccinia into the skin of the upper arm by multiple insertions of a bifurcated needle dipped into the vaccine. This inoculation allows the virus to grow and produce an immunologic response that leads to both an antibody and cellmediated immunity.…”

Section: Introductionmentioning

confidence: 99%

“…Known adverse reactions to the smallpox vaccine that may be life threatening include anaphylaxis, as well as possible association with cardiac reactions including myocarditis, pericarditis, infarction, and angina during its administration. 3 Currently, the CDC and Department of Defense (DoD) maintain active surveillance for potentially life-threatening, moderate to severe, and serious adverse events. 5 Other, nonserious adverse events are reported only through spontaneous surveillance, and their prevalence is expected to be underreported.…”

Section: Introductionmentioning

confidence: 99%

“…All of the vaccines contain the New York City Board of Health vaccinia strain, which has been shown to be less reactogenic. The two new vaccines are currently being studied for evidence of improved reactivity if a more extensive vaccination program is needed 3 …”

Section: Introductionmentioning

confidence: 99%

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Benign hypersensitivity reactions to smallpox vaccine

et al. 2007

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We describe a new exanthematous type of hypersensitivity reaction to the smallpox vaccine. Hypersensitivity reactions occur at a rate higher than previously reported. In a carefully screened military population, these three hypersensitivity reactions are much more common than life-threatening or serious reactions. Although the reactions have distinct clinical and pathologic features, they are all characterized by mild or absent systemic symptoms and a benign outcome.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Benign hypersensitivity reactions to smallpox vaccine

et al. 2007

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“…In the present era there have been tremendous advances in development of prophylactic vaccines against prevailing infectious diseases. The success of several of these vaccines relies on efficient elicitation of both mucosal and systemic immunity . Mucosal immunity plays a key role in inhibition and clearance of pathogen in the initial stage of infection.…”

mentioning

confidence: 99%

Dual recombinant Lactococcus lactis for enhanced delivery of DNA vaccine reporter plasmid pPERDBY

Yagnik¹,

Sharma²,

Padh

et al. 2017

Microbiology and Immunology

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Food grade Lactococcus lactis has been widely used as an antigen and DNA delivery vehicle. We have previously reported the use of non-invasive L. lactis to deliver the newly constructed immunostimulatory DNA vaccine reporter plasmid, pPERDBY. In the present report, construction of dual recombinant L. lactis expressing internalin A of Listeria monocytogenes and harboring pPERDBY (LL InlA + pPERDBY) to enhance the efficiency of delivery of DNA by L. lactis is outlined. After confirmation and validation of LL InlA + pPERDBY, its DNA delivery potential was compared with previously developed non-invasive r- L. lactis::pPERDBY. The use of invasive L. lactis resulted in around threefold increases in the number of enhanced green fluorescent protein-expressing Caco-2 cells. These findings reinforce the prospective application of invasive strain of L. lactis for delivery of DNA/RNA and antigens.

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“…Although the ACIP recommendations do not address the frequency with which workers are exposed to orthopoxviruses, they imply that even periodic exposure to these viruses might warrant the protection that only vaccination can provide. Some orthopoxviruses remain extremely dangerous (high rates of illness and death) for humans ( 4 ).…”

mentioning

confidence: 99%