2001
DOI: 10.1056/nejmra011223
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Vaccines and Vaccination

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Cited by 239 publications
(94 citation statements)
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“…It has already been known for a long time that protection against infections with S. pneumoniae is mediated by Abs to the caps-PS. Vaccination with pneumococcal caps-PS is widely used to protect people against infection with S. pneumoniae (15). ϩ T lymphocytes and Ͻ2.5% B lymphocytes and CD8 ϩ lymphocytes.…”
Section: Discussionmentioning
confidence: 99%
“…It has already been known for a long time that protection against infections with S. pneumoniae is mediated by Abs to the caps-PS. Vaccination with pneumococcal caps-PS is widely used to protect people against infection with S. pneumoniae (15). ϩ T lymphocytes and Ͻ2.5% B lymphocytes and CD8 ϩ lymphocytes.…”
Section: Discussionmentioning
confidence: 99%
“…We would like to consider, in an analogy to the immunologic memory (27)(28)(29)(30)(31), that the period shortly before and after birth might be the key in also understanding autoimmunity. Because at this phase of development the immune system is relatively incompetent, transferable maternal immunologic memory is essential for the survival of the fetus, newborn, and infant (32).…”
Section: Maternal Autoimmune Imprinting Predisposes Offspring To T1dmentioning
confidence: 99%
“…DNA vaccine constructs have been evaluated and tested in numerous human clinical trials for generating an immune response to various diseases, including infectious, allergic and autoimmune diseases, as well as cancers (11,12). Unfortunately, the immunogenicity of plasmid DNA in humans has proven to be modest as compared with the immunogenicity observed An enhanced immune response against G250, induced by a heterologous DNA prime-protein boost vaccination, using polyethyleneimine as a DNA vaccine adjuvant in other species treated using microbial expression vectors.…”
Section: Introductionmentioning
confidence: 99%