Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies

Taylor, Luke; Swerdfeger, Amy L.; Eslick, Guy D.

doi:10.1016/j.vaccine.2014.04.085

Cited by 433 publications

(281 citation statements)

References 29 publications

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“…This is in contrast to observations in developed countries where caregivers are beginning to reject immunization because of the misconception that it causes autism. [24][25][26] …”

Section: Discussionmentioning

confidence: 99%

Determinants of uptake of pentavalent vaccine in Benin city, Southern Nigeria

Ogboghodo

Esene

Okojie

2016

Int J Community Med Public Health

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“…This is in contrast to observations in developed countries where caregivers are beginning to reject immunization because of the misconception that it causes autism. [24][25][26] …”

Section: Discussionmentioning

confidence: 99%

Determinants of uptake of pentavalent vaccine in Benin city, Southern Nigeria

Ogboghodo

Esene

Okojie

2016

Int J Community Med Public Health

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“…In all cases it was noted by the Court of Federal Claims, or indicated in settlement agreements, that the children had autism or ASD [39]. On the other hand, numerous epidemiological studies have found no association between receipt of selected vaccines (in particular the combined measles, mumps, and rubella vaccine) and autism [10,[40][41][42][43][44][45], and there is no accepted mechanism by which vaccines could induce autism [46].…”

Section: Introductionmentioning

confidence: 99%

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children

Mawson¹,

Ray²,

Bhuiyan³

et al. 2017

J Transl Sci

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Vaccinations have prevented millions of infectious illnesses, hospitalizations and deaths among U.S. children, yet the long-term health outcomes of the vaccination schedule remain uncertain. Studies have been recommended by the U.S. Institute of Medicine to address this question. This study aimed 1) to compare vaccinated and unvaccinated children on a broad range of health outcomes, and 2) to determine whether an association found between vaccination and neurodevelopmental disorders (NDD), if any, remained significant after adjustment for other measured factors. A cross-sectional study of mothers of children educated at home was carried out in collaboration with homeschool organizations in four U.S. states: Florida, Louisiana, Mississippi and Oregon. Mothers were asked to complete an anonymous online questionnaire on their 6-to 12-year-old biological children with respect to pregnancy-related factors, birth history, vaccinations, physician-diagnosed illnesses, medications used, and health services. NDD, a derived diagnostic measure, was defined as having one or more of the following three closely-related diagnoses: a learning disability, Attention Deficient Hyperactivity Disorder, and Autism Spectrum Disorder. A convenience sample of 666 children was obtained, of which 261 (39%) were unvaccinated. The vaccinated were less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but more likely to have been diagnosed with pneumonia, otitis media, allergies and NDD. After adjustment, vaccination, male gender, and preterm birth remained significantly associated with NDD. However, in a final adjusted model with interaction, vaccination but not preterm birth remained associated with NDD, while the interaction of preterm birth and vaccination was associated with a 6.6-fold increased odds of NDD (95% CI: 2.8, 15.5). In conclusion, vaccinated homeschool children were found to have a higher rate of allergies and NDD than unvaccinated homeschool children. While vaccination remained significantly associated with NDD after controlling for other factors, preterm birth coupled with vaccination was associated with an apparent synergistic increase in the odds of NDD. Further research involving larger, independent samples and stronger research designs is needed to verify and understand these unexpected findings in order to optimize the impact of vaccines on children's health.

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“…Further, the history of publishing has shown that peer review does not necessarily guarantee scientific integrity [15][16][17]. There are numerous cases of influential peer-reviewed articles that were later retracted [15], such as articles correlating vaccination and autism [3,4], reporting the cloning of human embryos [5,18], and attributing morphology of the human hand to Intelligent Design [6]. As pointed out by Sheldon [1], uncritical reporting based on peer-reviewed articles can spread misinformation and harm.…”

Section: Textmentioning

confidence: 99%

Maintaining confidence in the reporting of scientific outputs

Sarabipour

Wissink

Burgess

et al. 2018

Preprint

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The timely and accurate dissemination of scientific discoveries is of utmost importance so that scientific knowledge can be advanced and applied to benefit the public. Scientists communicate amongst themselves at conferences, via journal articles, and, increasingly in the life sciences, in preprint manuscripts which have not been subject to peer review. Journalists translate new research into a language the public can understand, relying on both work presented in scientific forums and interviews with experts. Critically, scientists and journalists both share the ethical principle that publications should be rigorously sourced and fact-checked, with errors subject to publicized corrections. Here we respond to concerns raised about the impact of reporting on results that have not passed through peer review, calling for improved dialogue between PeerJ Preprints | https://doi.org/10.7287/peerj.preprints.27098v1 | CC BY 4.0 Open Access |

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Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies

Cited by 433 publications

References 29 publications

Determinants of uptake of pentavalent vaccine in Benin city, Southern Nigeria

Determinants of uptake of pentavalent vaccine in Benin city, Southern Nigeria

Pilot comparative study on the health of vaccinated and unvaccinated 6- to 12- year old U.S. children

Maintaining confidence in the reporting of scientific outputs

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