Vaccines are not yet a silver bullet: The imperative of continued communication about the importance of COVID-19 safety measures

Su, Zhaohui; Wen, Jun; McDonnell, Dean; Goh, Edmund; Li, Xiaoshan; Šegalo, Sabina; Ahmad, Junaid; Cheshmehzangi, Ali; Xiang, Yu‐Tao

doi:10.1016/j.bbih.2021.100204

Cited by 73 publications

(77 citation statements)

References 10 publications

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“…Until COVID-19 vaccinated becomes a universal fact [ 109 – 111 ], lockdowns and social distancing mandates will likely continue to be a solution when there are future outbreaks or infections. This barrier to physical contact paves the way for technology-based interventions to address domestic violence victims’ mental health issues [ 112 , 113 ].…”

Section: Discussionmentioning

confidence: 99%

Mental health solutions for domestic violence victims amid COVID-19: a review of the literature

McDonnell

Roth

et al. 2021

Global Health

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Background Due to COVID-19, domestic violence victims face a range of mental health challenges, possibly resulting in substantial human and economic consequences. However, there is a lack of mental health interventions tailored to domestic violence victims and in the context of COVID-19. In this study, we aim to identify interventions that can improve domestic violence victims’ mental health amid the COVID-19 pandemic to address the research gap. Main text Drawing insights from established COVID-19 review frameworks and a comprehensive review of PubMed literature, we obtained information on interventions that can address domestic violence victims’ mental health challenges amid COVID-19. We identified practical and timely solutions that can be utilized to address mental health challenges domestic violence victims face amid COVID-19, mainly focusing on (1) decreasing victims’ exposure to the abuser and (2) increasing victims’ access to mental health services. Conclusion Domestic violence is a public health crisis that affects all demographics and could result in significant morbidity and mortality. In addition to emphasizing mental health challenges faced by domestic violence victims, multidisciplinary interventions are identified that could provide timely and practical solutions to domestic violence victims amid the pandemic, which range from tailored shelter home strategies, education programs, escape plans, laws and regulations, as well as more technology-based mental health solutions. There is a significant need for more multipronged and multidisciplinary strategies to address domestic violence amid and beyond the pandemic, particularly interventions that could capitalize on the ubiquity and cost-effectiveness of technology-based solutions.

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Section: Discussionmentioning

confidence: 99%

Mental health solutions for domestic violence victims amid COVID-19: a review of the literature

McDonnell

Roth

et al. 2021

Global Health

Self Cite

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“…Despite this incredible progress on COVID-19, many challenges remain post vaccine development including ongoing vaccine deployment, large-scale production and distribution of billions of vaccine doses [21], and uncertainty over the effectiveness of current vaccines against more transmissible new variants [22]. These factors, combined with public hesitation around vaccination, have casted doubt on the likelihood of achieving worldwide herd immunity in the near future [23]. Consequently, other therapeutic strategies to impair virus infection or to counteract further disease spread are still needed, at least until more effective drugs are available or vaccines are distributed and administered to everyone [24].…”

Section: Introductionmentioning

confidence: 99%

Convalescent Plasma for the Prevention and Treatment of COVID-19: A Systematic Review and Quantitative Analysis

Peng¹,

Rhind²,

Beckett³

2021

JMIR Public Health Surveill

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Background The COVID-19 pandemic, caused by a novel coronavirus termed SARS-CoV-2, has spread quickly worldwide. Convalescent plasma (CP) obtained from patients following recovery from COVID-19 infection and development of antibodies against the virus is an attractive option for either prophylactic or therapeutic treatment, since antibodies may have direct or indirect antiviral activities and immunotherapy has proven effective in principle and in many clinical reports. Objective We seek to characterize the latest advances and evidence in the use of CP for COVID-19 through a systematic review and quantitative analysis, identify knowledge gaps in this setting, and offer recommendations and directives for future research. Methods PubMed, Web of Science, and Embase were continuously searched for studies assessing the use of CP for COVID-19, including clinical studies, commentaries, reviews, guidelines or protocols, and in vitro testing of CP antibodies. The screening process and data extraction were performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Quality appraisal of all clinical studies was conducted using a universal tool independent of study designs. A meta-analysis of case-control and randomized controlled trials (RCTs) was conducted using a random-effects model. Results Substantial literature has been published covering various aspects of CP therapy for COVID-19. Of the references included in this review, a total of 243 eligible studies including 64 clinical studies, 79 commentary articles, 46 reviews, 19 guidance and protocols, and 35 in vitro testing of CP antibodies matched the criteria. Positive results have been mostly observed so far when using CP for the treatment of COVID-19. There were remarkable heterogeneities in the CP therapy with respect to patient demographics, donor antibody titers, and time and dose of CP administration. The studies assessing the safety of CP treatment reported low incidence of adverse events. Most clinical studies, in particular case reports and case series, had poor quality. Only 1 RCT was of high quality. Randomized and nonrandomized data were found in 2 and 11 studies, respectively, and were included for meta-analysis, suggesting that CP could reduce mortality and increase viral clearance. Despite promising pilot studies, the benefits of CP treatment can only be clearly established through carefully designed RCTs. Conclusions There is developing support for CP therapy, particularly for patients who are critically ill or mechanically ventilated and resistant to antivirals and supportive care. These studies provide important lessons that should inform the planning of well-designed RCTs to generate more robust knowledge for the efficacy of CP in patients with COVID-19. Future research is necessary to fill the knowledge gap regarding prevention and treatment for patients with COVID-19 with CP while other therapeutics are being developed.

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“…A number of COVID-19 vaccines are currently being administered. While they have the potential to curb the pandemic, it is important to note that until the threshold for herd immunity is met, it remains important to implement behavioral interventions to minimize transmission through various routes discussed above [87]. Such interventions will also prevent the evolution of novel variants against which current vaccines might be less effective [88].…”

Section: Maintaining Preventive Behavioral Interventions During the Covid Vaccine Rolloutmentioning

confidence: 99%

Modes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions

et al. 2021

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COVID-19 is a novel disease caused by SARS-CoV-2. During the global vaccination rollout, it is vital to thoroughly understand the modes of transmission of the virus in order to prevent further spread of variants and ultimately to end the pandemic. The current literature suggests that SARS-CoV-2 is transmitted among the human population primarily through respiratory droplets and, to a lesser extent, via aerosols. Transmission appears to be affected by temperature, humidity, precipitation, air currents, pH, and radiation in the ambient environment. Finally, the use of masks or facial coverings, social distancing, and hand washing are effective public health strategies in reducing the risk of exposure and transmission. Additional research is needed to further characterize the relative benefits of specific nonpharmaceutical interventions.

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Vaccines are not yet a silver bullet: The imperative of continued communication about the importance of COVID-19 safety measures

Cited by 73 publications

References 10 publications

Mental health solutions for domestic violence victims amid COVID-19: a review of the literature

Mental health solutions for domestic violence victims amid COVID-19: a review of the literature

Convalescent Plasma for the Prevention and Treatment of COVID-19: A Systematic Review and Quantitative Analysis

Modes of transmission of SARS-CoV-2 and evidence for preventive behavioral interventions

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