Vaccines for preventing cutaneous leishmaniasis

Khanjani, Narges; González, Urbà; Leonardi‐Bee, Jo; Mohebali, M; Saffari, Mehri; Khamesipour, Ali

doi:10.1002/14651858.cd007634.pub2

Cited by 3 publications

(2 citation statements)

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“…5,14 However, decades of studies on Leishmania vaccine development have resulted in only a few first-generation vaccines in phase III clinical trials that showed limited or no efficacy in humans. 15 Limited efficacy in vaccines against leishmaniasis is partly related to the lack of a suitable adjuvant.…”

Section: Leishmaniasis Vaccinesmentioning

confidence: 99%

Liposomal adjuvant development for leishmaniasis vaccines

Askarizadeh

Jaafari

Khamesipour

et al. 2017

Therapeutic Advances in Vaccines

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Leishmaniasis is a parasitic disease that ranges in severity from skin lesions to fatality. Since long-lasting protection is induced upon recovery from cutaneous leishmaniasis, development of an effective vaccine is promising. However, there is no vaccine for use in humans yet. It seems limited efficacy in leishmaniasis vaccines is due to lack of an appropriate adjuvant or delivery system. Hence, the use of particulate adjuvants such as liposomes for effective delivery to the antigen presenting cells (APCs) is a valuable strategy to enhance leishmaniasis vaccine efficacy. The extraordinary versatility of liposomes because of their unique amphiphilic and biphasic nature allows for using antigens or immunostimulators within the core, on the surface or within the bilayer, and modulates both the magnitude and the T-helper bias of the immune response. In this review article, we attempt to summarize the role of liposomal adjuvants in the development of Leishmania vaccines and describe the main physicochemical properties of liposomes like phospholipid composition, surface charge, and particle size during formulation design. We also suggest potentially useful formulation strategies in order for future experiments to have a chance to succeed as liposomal vaccines against leishmaniasis.

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Section: Leishmaniasis Vaccinesmentioning

confidence: 99%

Liposomal adjuvant development for leishmaniasis vaccines

Askarizadeh

Jaafari

Khamesipour

et al. 2017

Therapeutic Advances in Vaccines

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“…Currently, 13 million people in 98 countries have different types of leishmaniasis ( 2 ), and according to a 2017 report from the World Health Organization, about 600,000 to 1 million new cases each year have become a public health hazard worldwide ( https://www.who.int/newsroom/fact-sheets/detail/leishmaniasis ). The most common form of leishmaniasis is the cutaneous form caused by the protozoan parasites belonging to the genus Leishmania ( 3 , 4 ). Drug resistance, limitary efficacy and severe side effects of common drugs such as sodium stibogluconate and meglumine antimoniate remain a challenge for treatment of cutaneous leishmaniasis ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of Foeniculum Vulgare Aqueous and Alcoholic Seed Extract against Zoonotic Cutaneous Leishmaniasis

Gholamrezaei¹,

Jalallou²,

javad³

et al. 2021

Ethiop J Health Sci

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BACKGROUND፡ Cutaneous leishmaniasis is considered one of the major neglected tropical diseases. Drug resistance, limitary efficacy, and severe side effects remain a challenge for treatment. Foeniculum vulgare is known as a medicinal plant belonging to the Apiaceae, and anti-microbial properties of this plant have already been confirmed.METHOD: The F.vulgare sterile aqueous and alcoholic extracts were prepared. In vitro has used RAW 264.7 cell line and L. major parasite (MRHO/IR/75/ER). Cytotoxicity assay on macrophages (CC50), cytotoxicity assay on promastigotes (IC50), and cytotoxicity assay on infected macrophages (EC50) were accomplished with both extracts by MTT and light microscopy methods. Four in vivo were allocated in four groups and five BALB/c mice each group. Stationary phase promastigotes were inoculated into the base of mice tails subcutaneously (SC).Measurement of the body weight, lesion size, parasite burden of the lesion, and spleen after 4 weeks for evaluation effects of the alcoholic extract on CL was done.RESULTS: The results of in vitro revealed that the optimal concentrations of both extracts reducing the promastigotes and amastigotes growth. Alcoholic extract no harmful side effects for the host macrophages, while were indicated has a potent action against L. major. In vivo results after 4 weeks did not show any variation in lesion size and body weight. Also, lesion size and spleen parasite burden decreased in comparison to no treatment group.CONCLUSION: The alcoholic extract could be a new alternative treatment for cutaneous leishmaniasis. However this extract needs more investigation for novel herbal drugs against CL.

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Leishmaniasis Increase and Causes in Kabul City

Samim,

Khan Amirzai,

Nafees

2023

J. Res. Appl. Sci. Biotechnol.

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Parasites of the genus Leishmania are pathogenic for humans and animals and cause leishmaniosis. This disease can be seen in three forms: cutaneous, cutaneous-mucous, and visceral. Identification of Leishmania species in clinical infections is very important for advancing awareness, control, and prevention of the disease. Kabul province in Afghanistan is one of the important places infected with Leishmania parasites. In this study, the prevalence of cutaneous leishmaniosis and its treatment methods in traditional medicine were studied in areas of Kabul province, Afghanistan. The population investigated in this study was primarily patients with cutaneous leishmaniosis who were referred to health centers (Leishmaniosis Hospitals) in endemic areas of the disease in the capital Kabul province. In addition to the capital of Kabul province, information on patients was also collected from different districts like Kart e now, Arzanqimat, Darlman, Desabz, Sarobi. Data collection of leishmaniasis patients was done using a questionnaire. After the statistical analysis of the obtained data, it was observed that women are significantly more affected by cutaneous leishmaniosis than men. It was also observed that gender, income, health facilities, travel, level of education, etc are effective in people suffering from this disease. Based on the collected information, the people of Kabul province use medicinal plants such as milk thistle, Asterberg, alkaloid plant, and Bolag oti to control leishmaniosis or Salak.

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Vaccines for preventing cutaneous leishmaniasis

Cited by 3 publications

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Liposomal adjuvant development for leishmaniasis vaccines

Liposomal adjuvant development for leishmaniasis vaccines

Effect of Foeniculum Vulgare Aqueous and Alcoholic Seed Extract against Zoonotic Cutaneous Leishmaniasis

Leishmaniasis Increase and Causes in Kabul City

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