Vaccines for the Future?

Gl, Ada

doi:10.1038/icb.1982.59

Cited by 6 publications

(3 citation statements)

References 37 publications

(42 reference statements)

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“…Sacks et al (26) also have reported evidence for antigen-independent immunization in ald Ab derived from anti-Trypanosoma mAb. We believe that our findings support the idea that immunization with aId Ab can induce specific virus-neutralizing responses, as has been theorized by other workers (1,14). Our findings also provide a basis for speculation on the incidence of naturally occurring aId Ab in humans treated with rabies immune globulin and its potential effect on the immune regulation network.…”

Section: Discussionsupporting

confidence: 90%

“…2), yet it failed to induce VNA. We cannot rule out the possibility that immunization of mice with this aId Ab resulted in the stimulation of suppressor T cells (12), the deletion of B cells possessing the relevant idiotype (1,23), or the induction of antibodies with too low an avidity to neutralize virus. Studies have shown that the induction or suppression of idiotopepositive B cells can depend upon the antibody class and the dose of aId Ab (12,18).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein

Reagan¹,

Wunner²,

Wiktor³

et al. 1983

J Virol

155

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Rabbit anti-idiotypic antibodies (aId Ab) were prepared against five murine monoclonal antibodies (mAb) specific for the rabies virus glycoprotein. Four of the mAb were directed against three known, type-specific, neutralizing sites on the glycoprotein, and the other mAb was directed against a topographically uncharacterized, nonneutralizing epitope. An absence of significant cross-reactivity among the aId Ab for heterologous mAb suggested that the aId Ab were highly specific for unique variable region determinants. The binding of three of the five aId Ab to their homologous mAb could be inhibited by rabies virus-soluble glycoprotein, suggesting that the aId Ab possessed subpopulations similar or adjacent to the antigen-binding site of the mAb. Two of the five aId Ab injected into mice elicited a specific virus-neutralizing antibody response. Mechanisms to account for the induction of the virus-neutralizing antibody by aId Ab are discussed. capsid mAb 515-3 (Y2a isotype) and 389-1 (-yl isotype) 660 on July 31, 2020 by guest

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Anti-idiotypic antibodies induce neutralizing antibodies to rabies virus glycoprotein

Reagan¹,

Wunner²,

Wiktor³

et al. 1983

J Virol

155

View full text Add to dashboard Cite

show abstract

“…Of the viruses listed, vaccinia has been most used (53). Reasons for this include: (1) It is the basis of the vaccine used to eradicate smallpox so that appropriate epidemiological and other data are available; (2) It has all the characteristics required of a vaccine for global use; (3) It is easy to insert large amounts of foreign DNA into the viral genome; thus. DNA coding for antigens from three separate disease agents has been incorporated into the virus and expressed in infected cells.…”

Section: Recombinant Vectors As the Basis Of Vaccinesmentioning

confidence: 99%