Vaccinia Virus—Laboratory Tool with a Risk of Laboratory-Acquired           Infection

Korioth-Schmitz, Birgit; Affeln, Dieter; Simon, Susanne L.; Decaneas, William M.; Schweon, Gary B.; Wong, Michael; Gardner, Adrian

doi:10.1177/153567601502000102

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Our brief review of LAIs that occurred from 2011-2020 uncovered 53 reports of 338 LAIs, including case reports and summary reports (Belchior et al, 2011;Britton et al, 2011;Buitrago et al, 2011;Centers for Disease Control and Prevention, 2011;Hitt, 2011;Horvat et al, 2011;Kaiser, 2011;Omer et al, 2011;Wunschel et al, 2011;Barrett 2012;Felinto de Brito et al, 2012;Lam et al, 2012;McCollum et al, 2012;Sayin-Kutlu et al, 2012;Seetharam et al, 2012;Centers for Disease C, Prevention, 2013;Cullen et al, 2013;Rodrigues et al, 2013;Cullen et al, 2014;Hartady et al, 2014;Herriman 2014;Riyesh et al, 2014;Sheets et al, 2014;Barker et al, 2015;Benoit et al, 2015;Hsu et al, 2015;Joyce et al, 2015;Korioth-Schmitz et al, 2015;Langford et al, 2015;Vranes et al, 2015;Aebischer et al, 2016;Alexander et al, 2016;Campos-Macıás et al, 2016;Duman et al, 2016;Garofolo et al, 2016;Leblebicioglu et al, 2016;Lee et al, 2016;Motlagh et al, 2016;Nedelman, 2016;Wurtz et al, 2016;…”

Section: Literature Analysis Of Lais For the Period 2011-2020mentioning

confidence: 99%

Zika Virus Infection During Research Vaccine Development: Investigation of the Laboratory-Acquired Infection via Nanopore Whole-Genome Sequencing

Bang

Chang³

et al. 2022

Front. Cell. Infect. Microbiol.

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Zika virus (ZIKV) emerged as a serious public health problem since the first major outbreak in 2007. Current ZIKV diagnostic methods can successfully identify known ZIKV but are impossible to track the origin of viruses and pathogens other than known ZIKV strains. We planned to determine the ability of Whole Genome Sequencing (WGS) in clinical epidemiology by evaluating whether it can successfully detect the origin of ZIKV in a suspected case of laboratory-acquired infection (LAI). ZIKV found in the patient sample was sequenced with nanopore sequencing technology, followed by the production of the phylogenetic tree, based on the alignment of 38 known ZIKV strains with the consensus sequence. The closest viral strain with the consensus sequence was the strain used in the laboratory, with a percent identity of 99.27%. We think WGS showed its time-effectiveness and ability to detect the difference between strains to the level of a single base. Additionally, to determine the global number of LAIs, a literature review of articles published in the last 10 years was performed, and 53 reports of 338 LAIs were found. The lack of a universal reporting system was worrisome, as in the majority of cases (81.1%), the exposure route was unknown.

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