Vaccinial infection in children with atopic dermatitis

Fries, Joseph H.; Borne, Stanford

doi:10.1016/0021-8707(49)90099-4

Cited by 11 publications

(1 citation statement)

References 22 publications

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“…Cutaneous viral infections caused by vaccinia virus (VV) called eczema vaccinatum and by herpes simplex virus (HSV) referred to as eczema herpeticum have been shown to occur primarily in AD patients (Wollenberg et al, 2003a). In fact it was in 1948, that the Journal of Pediatrics in a review article on generalized vaccinia recommended that ''patients with eczema should not be vaccinated and should not remain in the same household with those recently vaccinated'' (Fries and Borne, 1949). Since that time epidemiological data suggests that AD patients with more severe disease (earlier age of onset, persistence into adulthood, higher total IgE, higher Eczema Area and Severity Index scores) and with greater Th2 polarity (increased frequency of other atopic disorders and elevated serum thymus-and activation-regulated chemokine levels) are at greatest risk for skin infections with HSV or S. aureus (Wollenberg et al, 2003b;Guzik et al, 2005;Peng et al, 2007;Beck et al, 2008).…”

Section: Introduction Atopic Dermatitismentioning

confidence: 99%

Atopic Dermatitis: A Disease Caused by Innate Immune Defects?

Benedetto

Agnihothri

McGirt

et al. 2009

Journal of Investigative Dermatology

282

213

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Atopic dermatitis (AD) is a common chronic inflammatory skin disease that has increased in prevalence over the last half century. A growing body of evidence suggests that there are a variety of defects in the innate immune system that collectively affect the development and severity of AD. The reduction in antimicrobial peptides, diminished recruitment of innate immune cells (PMNs, pDC, and NK cells) to the skin, epithelial barrier disruption, and TLR2 defects are just some of the credible explanations for AD patients' susceptibility to pathogens such as Staphylococcus aureus, herpes simplex virus, and vaccinia virus. Although the focus for several years has been to identify defects in the innate immune system that might explain AD patients' susceptibility to cutaneous pathogens, it has become clear that some innate immune defects might promote inflammation and thereby aggravate or even induce the development of AD. Here we review the innate immune system, and highlight many of the potential innate networks that may be important in AD patients susceptible to cutaneous pathogens.

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