Vaccinium as Potential Therapy for Diabetes and Microvascular Complications

Luo, Yayong; Wang, Qian; Zhang, Yihan; Li, Zhongxia; He, Ruikun; Chen, Xiangmei; Dong, Zheyi

doi:10.3390/nu15092031

Cited by 5 publications

(3 citation statements)

References 182 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diabetic neuropathy (DNP) is the most common complication of diabetes mellitus ( 10 , 11 ). According to a systematic review conducted in Latin America, its prevalence can range from 21.3 to 34.5% in type 2 DM and type 1 diabetes mellitus between 7.0% and 34.2% ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Survival, incidence, and predictors of diabetic neuropathy among type 2 diabetic patients in hospitals of Addis Ababa

Tilahun,

Workina,

Habtamu

et al. 2024

Front. Clin. Diabetes Healthc.

View full text Add to dashboard Cite

BackgroundDiabetic neuropathy is a very common complication of diabetes mellitus. Thus, measuring the incidence of diabetic neuropathy is a key element in tracking the progress of epidemics of diabetes mellitus and an indication of early accessibility for healthcare in terms of type 2 diabetic patients.ObjectiveTo assess survival, incidence, and predictors of diabetic neuropathy among type 2 diabetic patients in hospitals of Addis Ababa from June 25 to August 25, 2023.MethodsAn institutional-based retrospective follow-up study design was used among newly diagnosed type 2 diabetic patients at hospitals of Addis Ababa. A chart review tool that contains socio-demographic, clinical, and comorbidity characteristics, biochemical characteristics, and the status of type 2 patients was used. A cleaned data was exported from Epi-data manager 4.6 version to SPSS version 25 for analysis. Bivariate Cox regression analysis was done to identify predictors of diabetic neuropathy at a 95% confidence level.ResultA total of 414 type 2 diabetic patients were included in the study. Of these, 97 (23.4%) developed diabetic neuropathy. Variables like having hypertension (AHR 11.25, 95% CI 3.73–33.93), anemia (AHR 4.18, 95% CI 1.78–9.82), high-density lipoprotein < 40 mg/dl (AHR 5.07, 95% CI 1.38–18.67), high creatinine level (AHR 14.67, 95% CI 4.27–50.40), diabetic retinopathy (AHR 4.32, 95% CI 1.32-14.18), and diabetic nephropathy (AHR 2.50, 95% CI 1.09–6.57) were associated with the incidence of diabetic neuropathy. The mean time to develop diabetic neuropathy was 4.94 years, CI (4.50–5.38), and the mean survival time was 6.61 years.ConclusionThe incidence of diabetic neuropathy was high relative to other studies. Variables like having hypertension, anemia, high-density lipoprotein, high creatinine level, diabetic retinopathy, and diabetic nephropathy were predictors of diabetic neuropathy. The mean time to develop diabetic neuropathy was 5 years, with a survival mean time of 7 years.

show abstract

Section: Introductionmentioning

confidence: 99%

“…It affects quality of life due to chronic pain, a high risk of falls, limb amputation, and foot ulceration. These manifestations of DNP further lead to sleep disorders, anxiety, and depression ( 6 , 10 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

Survival, incidence, and predictors of diabetic neuropathy among type 2 diabetic patients in hospitals of Addis Ababa

Tilahun,

Workina,

Habtamu

et al. 2024

Front. Clin. Diabetes Healthc.

View full text Add to dashboard Cite

show abstract

“…Significant efforts have been made to identify compounds able to inhibit ROS signaling pathways in order to counteract the MG-induced toxicity in EC with the aim of developing new potential therapeutic strategies in the treatment of diabetic vascular complications [18][19][20][21]. In this respect, plant polyphenols have attracted considerable interest as food supplements to ameliorate and prevent diabetic-related complications due to their multiple biological activities, including antioxidant, anti-inflammatory, and antidiabetic power [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Genistein Prevents Apoptosis and Oxidative Stress Induced by Methylglyoxal in Endothelial Cells

Liccardo,

Sapio,

Perrella

et al. 2024

Molecules

View full text Add to dashboard Cite

Glycolytic overload promotes accumulation of the highly reactive dicarbonyl compounds, resulting in harmful conditions called dicarbonyl stress. Methylglyoxal (MG) is a highly reactive dicarbonyl species and its accumulation plays a crucial pathophysiological role in diabetes and its vascular complications. MG cytotoxicity is mediated by reactive oxygen species (ROS) generation, a key event underlying the intracellular signaling pathways leading to inflammation and apoptosis. The identification of compounds able to inhibit ROS signaling pathways and counteract the MG-induced toxicity is a crucial step for developing new therapeutic strategies in the treatment of diabetic vascular complications. In this study, the effect of genistein, a natural soybean isoflavone, has been evaluated on MG-induced cytotoxicity in human endothelial cells. Our results show that genistein is able to counteract the MG-induced apoptosis by restraining ROS production, thus inhibiting the MAPK signaling pathways and caspase-3 activation. These findings identify a beneficial role for genistein, providing new insights for its potential clinical applications in preserving endothelial function in diabetic vascular complications.

show abstract

Nephroprotective effect of cranberry (Vaccinium oxycoccos) in streptozocin-induced diabetic nephropathy in mice

Shareef,

Khaleel,

Maryoosh

2024

Drug Metabolism and Personalized Therapy

View full text Add to dashboard Cite

Objectives Diabetic nephropathy is a chief reason of mortality particularly in individuals with renal dysfunction. The current research was aimed to assess the nephroprotective portion of Vaccinium oxycoccos toward mice diabetic nephropathy induced by streptozotocin (STZ). V. oxycoccos was purchased and used for hydroalcoholic extraction. Methods Sixty male mice were subjected to STZ-intraperitoneal injection (45 mg/kg). After diabetes induction, mice were divided into five groups of diabetic control (received only STZ), non-diabetic control (received only citrate buffer), two V. oxycoccos treatment (received V. oxycoccos extract (200 and 400 mg/kg) oral daily by gavage), and metformin treatment (received metformin (500 mg/kg) oral daily by gavage). Glucose and weight of mice were checked weekly. Results After 28 days, the effect of V. oxycoccos extract on serum and urine parameters were assessed. STZ caused significant decreased in the mice body weight. Mice treated with the V. oxycoccos (400 mg/kg) harbored the lowest weight loss at day 28 (70.2±1.38 g). STZ caused significant increase in the mice FBS. Mice treated with the V. oxycoccos (400 mg/kg) harbored the lowest FBS at day 28 (189.2±1.20 mg/dL). Treatment of mice with V. oxycoccos (400 mg/kg) caused the lowest increase in the levels of cholesterol, HbA1c and triglycerides compared to the diabetic control mice. Compared to the diabetic control group, mice treated with V. oxycoccos (400 mg/kg) had the highest HDL, insulin, SOD, and GSH (p<0.05). The lowest serum BUN, CR, and UR were found in mice treated with V. oxycoccos (400 mg/kg). Anti-inflammatory effects of V. oxycoccos (400 mg/kg) was shown by the lowest TNF-α, IL-6, and TGF-β1 concentration in mice treated with V. oxycoccos (400 mg/kg). Conclusions The current study disclosed that treatment with V. oxycoccos resulted in substantial development in the serum and urine parameters and also antioxidant and anti-inflammatory response of STZ-induced diabetic mice.

show abstract

Vaccinium as Potential Therapy for Diabetes and Microvascular Complications

Cited by 5 publications

References 182 publications

Survival, incidence, and predictors of diabetic neuropathy among type 2 diabetic patients in hospitals of Addis Ababa

Survival, incidence, and predictors of diabetic neuropathy among type 2 diabetic patients in hospitals of Addis Ababa

Genistein Prevents Apoptosis and Oxidative Stress Induced by Methylglyoxal in Endothelial Cells

Nephroprotective effect of cranberry (Vaccinium oxycoccos) in streptozocin-induced diabetic nephropathy in mice

Contact Info

Product

Resources

About