Vaccinium myrtillus leaves and Frangula alnus bark derived extracts as potential antistaphylococcal agents.

Sadowska, Beata; Paszkiewicz, Małgorzata; Podsędek, Anna; Redzynia, Małgorzata; Różalska, Barbara

doi:10.18388/abp.2014_1939

Cited by 23 publications

(24 citation statements)

References 36 publications

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“…The chemo-mapping of our extracts offers new insights into their composition, as to our knowledge, the previously reported bilberry extracts were highly focused on the anthocyanin content [2][3][4][5][6], rather than the complete phytochemical profile ( Table 1). The identified chemical classes ( Figure 2) are in agreement with reported composition of Vaccinium myrtillus L. extracts (Table S5) [35][36][37][38][39][40][41][42][43][44]. Moreover, they are in accordance with reported composition of the bilberry fruit, based on the report of the European Medicines Agency [35].…”

Section: Discussionsupporting

confidence: 88%

“…Approximately 40% of the compounds identified in our extracts have not been previously reported in Vaccinium spp., while 3 phytochemicals (cinnamtannin B1, cinnamtannin D1, and quercetin-3-O-galactoside) were only described in other species, and not for Vaccinium myrtillus L. (Table S5; Table S6-superscripts A , B , C ) [35][36][37][38][39][40][41][42][43][44]. Regarding the substances not reported earlier, it is, however, important to mention that the free amino acids presented in our study pertain to this category.…”

Section: Discussionmentioning

confidence: 60%

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Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis Regarding Their Phytonutrient Profiles, Antioxidant Capacity along with the In Vivo Rescue Effects Tested on a Drosophila melanogaster High-Sugar Diet Model

et al. 2020

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Bilberries (Vaccinium myrtillus L.) have been reported to hold a plentitude of health-promoting properties beyond basic nutrition, mainly attributed to their anthocyanin content and antioxidant activity. In this article, we built the phytochemical profile of three wild bilberry fruit extract formulations (aqueous, methanolic, and hydro-methanolic) using UHPLC-ESI-MS/MS putative analysis, identifying 88 individual phytochemicals, mainly flavonoids (total content 8.41 ± 0.11 mg QE/g dw), free amino acids, polyphenols (total content 21.68 ± 0.19 mg GAE/g dw), carboxylic acids, and vitamins. Furthermore, the antioxidant activity of the extract was assessed, reaching 78.03 ± 0.16% DPPH free radical scavenging activity, comparable to literature values determined for bilberry extracts of other origin. Due to the increased prevalence of metabolic syndrome and based on the reviewed benefits of bilberries, we tested the most potent formulation of our bilberry extracts in this biological context. The in vivo rescue effect of a bilberry extract supplemented diet on Drosophila melanogaster was assessed by monitoring biochemical and genomic markers. Hemolymph trehalose levels were halved upon addition of 3% hydro-methanolic bilberry extract to a high-sugar (1.5 M sucrose) diet, as compared to the non-supplemented high-sugar diet. Noteworthy, the rescue seen for flies kept on the bilberry extract supplemented high-sugar diet appeared to parallel the trehalose levels observed in the case of the control diet (50 mM sucrose) flies. Moreover, next to the trehalose-lowering type of in vivo effects, other gene expression related rescues were also detected for genes such as InR, Akh, AstA, AstC, Irk, Npc2g, and CCHa2 upon supplementation of the high-sugar diet with our hydro-methanolic bilberry fruit extract. Our findings suggest that such a bilberry fruit extract could generate physiological and genomic type of compensatory mechanisms so that further translational approaches would advance the understanding of some human specific pathological conditions.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 60%

Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis Regarding Their Phytonutrient Profiles, Antioxidant Capacity along with the In Vivo Rescue Effects Tested on a Drosophila melanogaster High-Sugar Diet Model

et al. 2020

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“…The anti-bacterial property of bilberry leaves extracts was validated by several studies; the anti-staphylococcal activity against two strains of Staphylococcus aureus, ATCC 29213 and H9 , resulted in a minimum inhibitory concentration (MIC) of 1500 μg/mL and a minimum bactericidal concentration (MBC) of 750 μg/mL [31]. The synergistic anti-staphylococcal effect of the extracts with antibiotics was also tested in the study; the MIC of some commonly used antibiotics against staphylococcal infections (linezolid and vancomycin), in combination with bilberry extract was decreased from 4 μg/mL and 1 μg/mL, to 1 μg/mL and 0.5 μg/mL for linezolid and vancomycin, respectively.…”

Section: Phenolic Compounds Present In Vaccinium Species Leavesmentioning

confidence: 99%

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

et al. 2019

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Some species of the Ericaceae family have been intensively studied because of the beneficial health impact, known since ancient times, of their chemical components. Since most studies focus on the effects of fruit consumption, this review aims to highlight the phenolic components present in the leaves. For this purpose, five species from Ericaceae family (bilberry—Vaccinium myrtillus L., lingonberry—V. vitis-idaea L., bog bilberry—V. uliginosum L., blueberry—V. corymbosum L. and bearberry—Arctostapylos uva-ursi L.) were considered, four of which can be found in spontaneous flora. The chemical composition of the leaves revealed three major phenolic compounds: chlorogenic acid, quercetin and arbutin. The health promoting functions of these compounds, such as antioxidant and anti-inflammatory properties that could have preventive effects for cardiovascular disease, neurodegenerative disorders, cancer, and obesity, have been exemplified by both in vitro and in vivo studies in this review. Furthermore, the importance of bioaccessibility and bioavailability of the phenolic compounds have been summarized. The findings highlight the fact that leaves of some Ericaceae species deserve increased attention and should be studied more profoundly for their biological activities, especially those from spontaneous flora.

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“…Bilberry leaves have been investigated for their antistaphylococcal activity; significant effectiveness against S. aureus enhancing, at the same time, the bactericidal potential of vancomycin and linezolid in combination, which has been documented [ 32 ]. Finally, bilberry leaves have been explored for their protective activities against cancer.…”

Section: Bilberry ( Vaccinium Myrtillus ) Leavementioning

confidence: 99%

Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value

2016

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Berry fruits are recognized, worldwide, as “superfoods” due to the high content of bioactive natural products and the health benefits deriving from their consumption. Berry leaves are byproducts of berry cultivation; their traditional therapeutic use against several diseases, such as the common cold, inflammation, diabetes, and ocular dysfunction, has been almost forgotten nowadays. Nevertheless, the scientific interest regarding the leaf composition and beneficial properties grows, documenting that berry leaves may be considered an alternative source of bioactives. The main bioactive compounds in berry leaves are similar as in berry fruits, i.e., phenolic acids and esters, flavonols, anthocyanins, and procyanidins. The leaves are one of the richest sources of chlorogenic acid. In various studies, these secondary metabolites have demonstrated antioxidant, anti-inflammatory, cardioprotective, and neuroprotective properties. This review focuses on the phytochemical composition of the leaves of the commonest berry species, i.e., blackcurrant, blackberry, raspberry, bilberry, blueberry, cranberry, and lingonberry leaves, and presents their traditional medicinal uses and their biological activities in vitro and in vivo.

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Vaccinium myrtillus leaves and Frangula alnus bark derived extracts as potential antistaphylococcal agents.

Cited by 23 publications

References 36 publications

Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis Regarding Their Phytonutrient Profiles, Antioxidant Capacity along with the In Vivo Rescue Effects Tested on a Drosophila melanogaster High-Sugar Diet Model

Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis Regarding Their Phytonutrient Profiles, Antioxidant Capacity along with the In Vivo Rescue Effects Tested on a Drosophila melanogaster High-Sugar Diet Model

Phenolic Compounds from Five Ericaceae Species Leaves and Their Related Bioavailability and Health Benefits

Berry Leaves: An Alternative Source of Bioactive Natural Products of Nutritional and Medicinal Value

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