Vaccinology: past achievements, present roadblocks and future promises

André, Francis

doi:10.1016/s0264-410x(02)00702-8

Cited by 147 publications

(90 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1 As a result, an increasing number of parents perceive the potential safety and health risks of vaccinations to be greater than the risks associated with VPDs. [2][3][4][5][6][7] As of 2009, approximately one in 8 US parents reported having refused at least one vaccine for their children and thus could be defined as "vaccine-hesitant." 8 The measles, mumps and rubella (MMR) vaccine is frequently questioned by parents regarding its safety and necessity.…”

Section: Introductionmentioning

confidence: 99%

A pilot study on the effects of individually tailored education for MMR vaccine-hesitant parents on MMR vaccination intention

Gowda

Schaffer

Kopec

et al. 2013

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

A pilot study on the effects of individually tailored education for MMR vaccine-hesitant parents on MMR vaccination intention

Gowda

Schaffer

Kopec

et al. 2013

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

“…To date, vaccination is the most effective strategy for protection against morbidity and mortality associated with infectious agents [1]. The exact immunological mechanisms which serve as the critical protective factor/s vary widely depending upon the specific pathogen [2].…”

Section: Introductionmentioning

confidence: 99%

Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen

Thompson

Whitmore²,

Staats

et al. 2008

Vaccine

View full text Add to dashboard Cite

Alphavirus replicon particles induce strong antibody and CD8 + T cell responses to expressed antigens in numerous experimental systems. We have recently demonstrated that Venezuelan equine encephalitis virus replicon particles (VRP) possess adjuvant activity for systemic and mucosal antibody responses. In this report, we demonstrate that VRP induced an increased and balanced serum IgG subtype response to co-delivered antigen, with simultaneous induction of antigen-specific IgG1 and IgG2a antibodies, and increased both systemic and mucosal antigenspecific CD8 + T cell responses, as measured by an IFN-γ ELISPOT assay. Additionally, VRP further increased antigen-specific T cell immunity in an additive fashion following co-delivery with the TLR ligand, CpG DNA. VRP infection led to recruitment of CD8 + T cells into the mucosal compartment, possibly utilizing the mucosal homing receptor, as this integrin was upregulated on CD8 + T cells in the draining lymph node of VRP-infected animals, where VRPinfected dendritic cells reside. This newly recognized ability of VRP to mediate increased T cell response towards co-delivered antigen provides the potential to both define the molecular basis of alphavirus-induced immunity, and improve alphavirus-based vaccines.

show abstract

“…Thus Andre´(2003), for example, suggests that 'a small group of the so-called educated in developed countries', who constitute an 'anti-vaccination movement' has been misclassifying health events after vaccination as vaccine reactions. Fitzpatrick (2004) makes this argument in relation to MMR.…”

Section: Introductionmentioning

confidence: 99%

‘MMR talk’ and vaccination choices: An ethnographic study in Brighton

Poltorak

Leach

Fairhead

et al. 2005

Social Science & Medicine

164

136

View full text Add to dashboard Cite

In the context of the high-profile controversy that has unfolded in the UK around the measles, mumps and rubella (MMR) vaccine and its possible adverse effects, this paper explores how parents in Brighton, southern England, are thinking about MMR for their own children. Research focusing on parents' engagement with MMR has been dominated by analysis of the proximate influences on their choices, and in particular scientific and media information, which have led health policy to focus on information and education campaigns. This paper reports ethnographic work including narratives by mothers in Brighton. Our work questions such reasoning in showing how wider personal and social issues shape parents' immunisation actions. The narratives by mothers show how practices around MMR are shaped by personal histories, by birth experiences and related feelings of control, by family health histories, by their readings of their child's health and particular strengths and vulnerabilities, by particular engagements with health services, by processes building or undermining confidence, and by friendships and conversations with others, which are themselves shaped by wider social differences and transformations. Although many see vaccination as a personal decision which must respond to the particularities of a child's immune system, 'MMR talk', which affirms these conceptualisations, has become a social phenomenon in itself. These perspectives suggest ways in which people's engagements with MMR reflect wider changes in their relations with science and the state. r

show abstract

Vaccinology: past achievements, present roadblocks and future promises

Cited by 147 publications

References 7 publications

A pilot study on the effects of individually tailored education for MMR vaccine-hesitant parents on MMR vaccination intention

A pilot study on the effects of individually tailored education for MMR vaccine-hesitant parents on MMR vaccination intention

Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen

‘MMR talk’ and vaccination choices: An ethnographic study in Brighton

Contact Info

Product

Resources

About