Vaccins, adjuvants et réponse immunitaire post-vaccinale : bases immunologiques

Miot, Charline; Poli, Caroline; Vinatier, Emeline; Jeannin, Pascale; Beauvillain, Céline

doi:10.1016/s1773-035x(19)30257-6

Cited by 2 publications

(2 citation statements)

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“…L'immunologie nous apprend Dossier scientifique Les enjeux des vaccinations que la réponse immunitaire à un antigène exogène est un phénomène complexe, faisant intervenir de nombreux acteurs, cellulaires et humoraux, dont l'étape première, la présentation de l'antigène par les cellules dendritiques aux lymphocytes T auxiliaires (helper) dépend des molécules du complexe majeur d'histocompatibilité, dont la panoplie est différente d'un individu à l'autre sauf pour les jumeaux vrais, ce qui peut expliquer les différences individuelles de susceptibilité aux différents vaccins (cf. Miot et al [29]). Pour reproduire la complexité de la réponse immunitaire anti-infectieuse et la nécessaire phase inflammatoire sans qui l'introduction d'un antigène exogène purifié n'entraînerait pas de réaction des lymphocytes, on incorpore dans les préparations vaccinales des adjuvants dans le but de stimuler la réponse de l'immunité naturelle [26].…”

Section: Les Oppositions Aux Vaccins Dans La Sociétéunclassified

Les vaccinations : historique et sociologie, à l’aune de l’immunologie

Chevailler

2019

Revue Francophone des Laboratoires

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Vaccination: history and sociology, in the light of immunology Vaccinating is a medical act of prevention of infectious diseases that has been proven for more than two centuries to be effective, whose symbol is the eradication of smallpox, which was its first target. To understand the social issues involved in this practice, we must call on historians to identify the different actors and their relationships (public authorities, health professionals, drug manufacturers), to draw the consequences of accidents that may have marked, on epidemiologists to define the notion of maximum coverage threshold, those of individual immunity and group or gregarious immunity, to sociologists to understand their acceptability, mistrust or refusal by the population and to immunologists who have progressively build the conceptual support to better understand the physiology of the immune response involved in this initially empirical practice, and thereby improve its performance. MOTS CLÉS ◗ politique vaccinale ◗ seuil de couverture vaccinale ◗ vaccination ◗ vaccins KEY WORDS ◗ vaccination ◗ vaccination coverage threshold ◗ vaccination policy ◗ vaccines AMM : Autorisation de mise sur le marché ANSM : Agence nationale de sécurité du médicament BCG : Bacille de Calmette et Guérin BEH : Bulletin épidémiologique hebdomadaire CRPV : Centres régionaux de pharmacovigilance CTV : Conseil technique des vaccinations HCSP : Haut Conseil de la santé publique MAI : Maladies auto-immunes ROR : Vaccin anti-rougeole, oreillons et rubéole

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Section: Les Oppositions Aux Vaccins Dans La Sociétéunclassified

Les vaccinations : historique et sociologie, à l’aune de l’immunologie

Chevailler

2019

Revue Francophone des Laboratoires

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“…Some factors may negatively affect the immunization and the child will risk an infection despite the vaccine administration. Among these factors, in literature we have: a hepatitis B infection in the mother [7], the poor nutritional status [8], an HIV infection of the child [9], the low number of doses [10], the poor type of vaccine [11], and the male sex of the child [3]. In SSA, problems associated with conservation and cold chain of these vaccines could also affect their efficiency [3].…”

Section: Introductionmentioning

confidence: 99%

Factors Associated with Antibody Levels among Children Aged 15 to 59 Months Vaccinated against Hepatitis B during the Expanded Program on Immunization in Cameroon

Ndam¹,

Mefire²,

Bekolo³

et al. 2023

OJGas

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Background: the hepatitis B virus infection remains a major public health problem worldwide. It can lead to a liver cirrhosis and/or hepatocellular carcinoma. The World Health Organisation (WHO) has recommended the implementation of generalised vaccination programs against hepatitis B. In Cameroon, this vaccine was introduced in the expanded program on immunization (EPI) in 2005, but few studies have assessed the immune response. Objective: the general objective of this study was to identify factors associated with antibody levels among children aged from 15 to 59 months vaccinated against hepatitis B during the EPI in Cameroon. Method: this was a crosssectional study carried out from December 2021 to June 2022 in a paediatric centre of Yaoundé (Cameroon). We analysed the antibody level in children vaccinated against hepatitis B within the framework of the EPI. We enrolled children who had received a series of 3 intramuscular doses of hepatitis B vaccine at 6, 10 and 14 weeks after birth. Some children could receive a 4 th booster dose between 12 months. The antibody level was assessed by measuring the anti-HBs in such children, aged 15 -59 months. A good immunization was defined as a serum level of anti-HBs antibody level above 100 IU/mL; a poor immunization, for an anti-HBs antibody level between 10 and 100 IU/mL; and a non-immunization, for an anti-HBs antibody level < 10 IU/mL.

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Vaccins, adjuvants et réponse immunitaire post-vaccinale : bases immunologiques

Cited by 2 publications

References 25 publications

Les vaccinations : historique et sociologie, à l’aune de l’immunologie

Les vaccinations : historique et sociologie, à l’aune de l’immunologie

Factors Associated with Antibody Levels among Children Aged 15 to 59 Months Vaccinated against Hepatitis B during the Expanded Program on Immunization in Cameroon

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