Vacuolated oocytes: fertilization and embryonic arrest following intra-cytoplasmic sperm injection in a patient exhibiting persistent oocyte macro vacuolization—Case report

Wallbutton, Sarah; Kasraie, Jason

doi:10.1007/s10815-010-9399-2

Cited by 27 publications

(18 citation statements)

References 16 publications

(27 reference statements)

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“…In the present study, the high viscosity of the cytoplasm and vacuoles had a negative influence on fertilization rates; this finding is consistent with several previous studies . However, our finding also demonstrated a positive impact of the presence of dark ZP on fertilization rate, which indicates that some features of morphological changes of oocyte can have a positive impact on fertilization rate.…”

Section: Discussionsupporting

confidence: 93%

Effect of oocyte dysmorphisms on intracytoplasmic sperm injection cycle outcomes in normal ovarian responders

Ashrafi

Karimian

Eftekhari‐Yazdi

et al. 2015

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 93%

Effect of oocyte dysmorphisms on intracytoplasmic sperm injection cycle outcomes in normal ovarian responders

Ashrafi

Karimian

Eftekhari‐Yazdi

et al. 2015

J of Obstet and Gynaecol

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“…The multiple anomalies and the high number of degenerated oocytes indicates that these oocytes endured serious intrinsic adverse effects during oogenesis and maturation. The present report confirms previous findings (Akarsu et al, 2009;Wallbutton and Kasraie, 2010) and clearly shows that oocyte anomalies can be a recurrent phenomenon in the same patient.…”

Section: Discussionsupporting

confidence: 93%

“…Determining the effect of a single oocyte dysmorphism is quite difficult because many oocytes show more than one morphological abnormality (De Sutter et al, 1996). It has also been reported that serious oocyte dysmorphisms, such as clusters and vacuoles in the cytoplasm, can be a recurrent phenomenon in consecutive IVF treatments for the same patient (Akarsu et al, 2009;Wallbutton and Kasraie, 2010). In these cases, it is often difficult to counsel patients as to how to proceed.…”

Section: Introductionmentioning

confidence: 99%

Human oocytes containing large cytoplasmic vacuoles can result in pregnancy and viable offspring

Fancsovits

Murber

Gilán

et al. 2011

Reproductive BioMedicine Online

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The effect of oocyte dysmorphism on further embryo development is controversial. It is generally accepted that serious oocyte abnormalities can have a negative effect on further fertilization and development. A couple reported to the clinic following 2 years of infertility and underwent five IVF/intracytoplasmic sperm injection treatments due to severe male factor infertility. A total of 42 oocytes were collected. The majority of the oocytes showed at least one large, fluid-filled and centrally located cytoplasmic vacuole and unusually thin zona pellucida. Only seven oocytes showed normal fertilization. The first four IVF treatments did not result in pregnancy. In the fifth IVF treatment, three poor-quality vacuolized embryos were transferred. A singleton pregnancy was detected. A baby girl was born at term who required surgery because of a double left kidney and ureter. This case report demonstrates that serious oocyte abnormalities can be a recurrent phenomenon in the same patient. However, the presence of a large vacuole does not completely block the fertilization process and this abnormal cohort of oocytes can still result in normal embryo development and a viable offspring. Rigorous prenatal care and follow-up should be carried out following the transfer of embryos developed from dysmorphic oocytes.

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“…Exposure to various toxicants caused ooplasmic vacuolization in fish (Akbulut, Dinc, Genc, Zengin, & Deniz, 2018;Saravanan, Uma, & Jothi, 2016). In clinical in vitro fertilization, oocyte vacuolization is a common observation and suggested as due to uncontrollable endocytosis or poor exocytosis (Balaban et al, 2008;Wallbutton & Kasraie, 2010). The ovarian disruption could also be due to hormonal imbalance in response to salinity stress.…”

Section: Discussionmentioning

confidence: 99%

Exposure to salinity stress cause ovarian disruption in a stenohaline freshwater teleost, Heteropneustes fossilis (Bloch, 1794)

et al. 2020

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Stenohaline freshwater fish with narrow salinity tolerance are susceptible to saline stress from global climate change and anthropogenic activities. The present study elucidated that saline exposure during the sensitive window of preparatory phase of oocyte maturation significantly affected gonadosomatic index, ovarian histology and morphometric features of oocytes in a stenohaline freshwater catfish, Heteropneustes fossilis (Bloch, 1794) in a dose (2 ppt, 5 ppt)—and duration (8, 24 days)‐dependent manner. The gonads of H. fossilis show annual maturation cycle. Loss of integrity of ovigerous lamellae, disruption of ovarian stroma, disrupted oolemma, ooplasmic vacuolization, damaged germinal vesicles and altered morphometry of previtellogenic oocytes, such as chromatin‐nucleolus, early perinucleolar and late perinucleolar, elucidated consistent effects of saline exposure except at 8 days exposure to 2 ppt of saline. Increased salinity might have affected the transmembrane ion/water transport and disrupted the osmotic balance in ovary that eventually led to impairment in growth of ovary and oocyte maturation. The susceptibility of ovary to comparatively less concentrations of saline exposure might be due to sensitiveness of ovary/oocytes during the early phase of growth. Fluctuating salinity along with other stressors can affect metabolic and growth rates, fecundity and ultimately survival of fish.

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Vacuolated oocytes: fertilization and embryonic arrest following intra-cytoplasmic sperm injection in a patient exhibiting persistent oocyte macro vacuolization—Case report

Abstract: It is likely that persistent Oocyte Macro Vacuolization is the cause of infertility in this patient. It probably has a biological basis and possibly a genetic cause, resulting in either uncontrollable endocytosis or poor exocytosis and consequent vacuolar formation.

Cited by 27 publications

References 16 publications

Effect of oocyte dysmorphisms on intracytoplasmic sperm injection cycle outcomes in normal ovarian responders

Effect of oocyte dysmorphisms on intracytoplasmic sperm injection cycle outcomes in normal ovarian responders

Human oocytes containing large cytoplasmic vacuoles can result in pregnancy and viable offspring

Exposure to salinity stress cause ovarian disruption in a stenohaline freshwater teleost, Heteropneustes fossilis (Bloch, 1794)

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