1998
DOI: 10.1086/515600
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Vacuolating Toxin Production in Clinical Isolates of Helicobacter pylori with Different vacA Genotypes

Abstract: A vacuolating cytotoxin encoded by vacA in Helicobacter pylori is known as a potential virulent determinant. The relationship between different vacA alleles, vacuolating ability, and H. pylori-related diseases was investigated. Genetic analysis of 119 isolates from Taiwanese patients revealed that 104 strains were s1a/m2, 13 strains were characterized as the s1a/m1T type, which was more homologous to the s1a/m1 strains, and 2 were characterized as the s1a/m1Tm2 chimeric type. Production of high-grade cytotoxin… Show more

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Cited by 71 publications
(79 citation statements)
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“…Correlating the histologic findings of gastritis with the genotypes, like iceA, or combination of iceA, vacA and cagA, no particular allelic mosaicism could be identified as responsible for neutrophil and mononuclear cell infiltration, formation of lymphoid follicles and aggregates, atrophic and metaplastic changes and the successive disease outcome. This is in consistent with the findings of few earlier reports [21,22] . An apparent correlation has still to be detected between the different genetic features of H pylori strains and the histologic findings of the disease outcome.…”
Section: Discussionsupporting
confidence: 94%
“…Correlating the histologic findings of gastritis with the genotypes, like iceA, or combination of iceA, vacA and cagA, no particular allelic mosaicism could be identified as responsible for neutrophil and mononuclear cell infiltration, formation of lymphoid follicles and aggregates, atrophic and metaplastic changes and the successive disease outcome. This is in consistent with the findings of few earlier reports [21,22] . An apparent correlation has still to be detected between the different genetic features of H pylori strains and the histologic findings of the disease outcome.…”
Section: Discussionsupporting
confidence: 94%
“…This part of vacA is less variable than the mid region (Table 2), and in other bacteria recombination frequency decreases exponentially with sequence divergence [20]. Strain Ch2 possesses the only vacA allele demonstrating recombination between m1 and m2 mid region sequences that we have found among 77 strains that we have screened from the USA, Peru, Japan, Thailand, and China (J. Atherton, unpublished data), although others have described occasional vacA alleles with a similar structure in Chinese strains [17,27]. Furthermore, in the Ch2 allele, the recombination site is contained in a short stretch of sequence that is more similar between m1 and m2 alleles than are surrounding areas.…”
Section: Discussionmentioning
confidence: 79%
“…H. pylori strains with either allele are widespread in most human populations examined, although type m2 alleles are rare among the Japanese (16,216,536). Analysis of H. pylori isolates from unrelated individuals indicates that recombination within the alleles is common (471), but the main families have remained relatively intact (15,379,524). This suggests that various in vivo selective forces favor the preservation of these structures.…”
Section: Vaca the Vacuolating Cytotoxinmentioning
confidence: 99%