Vacuum-Assisted Closure: A New Method for Wound Control and Treatment

Morykwas, Michael J.; Argenta, Louis C.; Shelton-Brown, Erica I.; McGuirt, Wyman T.

doi:10.1097/00000637-199706000-00001

Cited by 2,032 publications

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“…The original NPWT recommendation is -125 mmHg for pressure ulcers (black foam) to -175 mmHg (white foam), as outlined by Morykwas et al 18 1997. The studies 3,26,29 reported in this review applied pressure of -125 mmHg to surgical spinal wounds.…”

Section: Discussionmentioning

confidence: 99%

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Negative pressure wound therapy (NPWT) for spinal wounds: a systematic review

et al. 2013

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Section: Discussionmentioning

confidence: 99%

“…This may in turn promote wound healing 16 . Secondly, an experimental study has shown that NPWT reduces the bacterial load and the potential for bacterial colonisation 18 . Finally, NPWT wound healing occurs via a mechanical effect on the wound bed.…”

Section: Description Of the Interventionmentioning

confidence: 99%

Negative pressure wound therapy (NPWT) for spinal wounds: a systematic review

et al. 2013

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“…Subacute closure is defined as closure between 3 and 7 days. Data for late wound coverage, defined as closure after 7 days, also were reported [6,15,16,30,35,39]. For the purposes of this review, we considered early closure as before 72 hours.…”

Section: Search Strategy and Criteriamentioning

confidence: 99%

“…In Grade IIIB tibia wounds negative pressure wound therapy has the added expectation of sealing the wound from the hospital environment, acting as a temporary dermal substitute, and preventing bacterial access to the wound bed. The decrease in bacterial load [43,54] and initiation of granulation tissue formation [2,19,24,39] reported in some studies, to our knowledge, has not been reviewed or summarized for Grade IIIB tibia fractures. It also has yet to be reported whether negative pressure wound therapy is associated with favorable outcomes, such as fewer infections or flap procedures with days or weeks of therapy.…”

Section: Introductionmentioning

confidence: 98%

“…In 1997, the FDA approved negative pressure wound therapy. Subsequently, animal studies [39,41] and additional clinical reports that favored negative pressure wound therapy to reduce edema, decrease bacterial loads, increase granulation tissue formation, and other pathways to promote wound healing [2,38] were published. The majority of studies however, regard chronic or diabetic wounds [5,8,18,42,43,52].…”

Section: Introductionmentioning

confidence: 99%

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Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer Infections and Fewer Flap Procedures?

Schlatterer

Hirschfeld

Webb

2015

Clinical Orthopaedics &Amp; Related Research

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Background Grade IIIB open tibia fractures are devastating injuries. Some clinicians advocate wound closure or stable muscle flap coverage within 72 hours to limit complications such as infection. Negative pressure wound therapy was approved by the FDA in 1997 and has become an adjunct for many surgeons in treating these fractures. Opinions vary regarding the extent to which negative pressure wound therapy contributes to limb salvage. Evidence-based practice guidelines are limited for use of negative pressure wound therapy in Grade IIIB tibia fractures. This systematic literature review of negative pressure wound therapy in Grade IIIB tibia fractures may substantiate current use and guide future studies. Questions/purposes We sought to answer the following:(1) Does the use of negative pressure would therapy compared with gauze dressings lead to fewer infections? (2) Does it allow flap procedures to be performed safely beyond 72 hours without increased infection rates? (3) Is it associated with fewer local or free flap procedures? Methods We conducted a systematic review of six large databases (through September 1, 2013) for studies reporting use of negative pressure wound therapy in Grade IIIB open tibia fractures, including information regarding infection rates and soft tissue reconstruction. The systematic review identified one randomized controlled trial and 12 retrospective studies: four studies compared infection rates between negative pressure wound therapy and gauze dressings, 10 addressed infection rates with extended use, and six reported on flap coverage rates in relation to negative pressure wound therapy use beyond 72 hours. None of the 13 studies was eliminated owing to lack of study quality.

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Topical Negative Pressure Devices

Shirakawa

Isseroff²

2005

Arch Dermatol

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Vacuum-Assisted Closure: A New Method for Wound Control and Treatment

Cited by 2,032 publications

References 0 publications

Negative pressure wound therapy (NPWT) for spinal wounds: a systematic review

Negative pressure wound therapy (NPWT) for spinal wounds: a systematic review

Negative Pressure Wound Therapy in Grade IIIB Tibial Fractures: Fewer Infections and Fewer Flap Procedures?

Topical Negative Pressure Devices

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