We investigate the constraints on the leptoquark Yukawa couplings and Higgs-leptoquark quartic couplings for scalar doublet leptoquark R 2 , scalar triplet leptoquark S 3 and their combination with both three generations and one generation from perturbative unitarity and vacuum stability. Perturbative unitarity of all the dimensionless couplings have been studied via one-and two-loop beta-functions. Introduction of new SU (2) multiplets in terms of these leptoquarks fabricate Landau poles at two-loop level in the gauge coupling g 2 at 10 19.7 GeV and 10 14.4 GeV, respectively for S 3 and R 2 + S 3 models with three generations. However, such Landau pole cease to exits for R 2 and any of these extensions with both one and two generations till Planck scale. The Higgs-leptoquark quartic couplings acquire sever constraints to protect Planck scale perturbativity, whereas leptoquark Yukawa couplings gets some upper bound in order to respect Planck scale stability of Higgs Vacuum. The Higgs quartic coupling at two-loop constraints the leptoquark Yukawa couplings for R 2 , S 3 , R 2 + S 3 with values < ∼ 1.30, 3.90, 1.00 with three generations. In the effective potential approach, the presence of any of these leptoquarks with any number of generations pushes the metastable vacuum of the Standard Model to the stable region.