Vacuum therapy in dermatology: a review

Renner, Regina; Rogalski, Christina; Friedlein, Helmut; Simon, Jan C.

doi:10.1111/j.1610-0387.2006.06004.x

Cited by 10 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, the generation of pores increases fibers interconnectivity in the scaffold, which dictates the degree of cellular infiltration and tissue ingrowth, influencing a vast range of cellular processes. In addition, the pores are crucial for diffusion of nutrients, metabolites and waste products, or in this case the wound exudate [68,[71][72][73][74][75][76][77]. In addition, PVP release could confer a softer surface of the mats, being a comfortable characteristic for the user, because no further stress is given to the site of the wound.…”

Section: Discussionmentioning

confidence: 99%

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

et al. 2020

View full text Add to dashboard Cite

Skin burns and ulcers are considered hard-to-heal wounds due to their high infection risk. For this reason, designing new options for wound dressings is a growing need. The objective of this work is to investigate the properties of poly (ε-caprolactone)/poly (vinyl-pyrrolidone) (PCL/PVP) microfibers produced via electrospinning along with sorbents loaded with Argovit™ silver nanoparticles (Ag-Si/Al2O3) as constituent components for composite wound dressings. The physicochemical properties of the fibers and sorbents were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). The mechanical properties of the fibers were also evaluated. The results of this work showed that the tested fibrous scaffolds have melting temperatures suitable for wound dressings design (58–60 °C). In addition, they demonstrated to be stable even after seven days in physiological solution, showing no macroscopic damage due to PVP release at the microscopic scale. Pelletized sorbents with the higher particle size demonstrated to have the best water uptake capabilities. Both, fibers and sorbents showed antimicrobial activity against Gram-negative bacteria Pseudomona aeruginosa and Escherichia coli, Gram-positive Staphylococcus aureus and the fungus Candida albicans. The best physicochemical properties were obtained with a scaffold produced with a PCL/PVP ratio of 85:15, this polymeric scaffold demonstrated the most antimicrobial activity without affecting the cell viability of human fibroblast. Pelletized Ag/Si-Al2O3-3 sorbent possessed the best water uptake capability and the higher antimicrobial activity, over time between all the sorbents tested. The combination of PCL/PVP 85:15 microfibers with the chosen Ag/Si-Al2O3-3 sorbent will be used in the following work for creation of wound dressings possessing exudate retention, biocompatibility and antimicrobial activity.

show abstract

Section: Discussionmentioning

confidence: 99%

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

et al. 2020

View full text Add to dashboard Cite

show abstract

“…To date, there is only limited data on NPWTi in skin diseases. In 2006, Renner et al published a comprehensive review of the use of VAT in dermatology [55]. However, there are no large randomized studies comparing NPWT with or without instillation in the treatment of skin diseases.…”

Section: Studies In Dermatologymentioning

confidence: 99%

On the significance of negative‐pressure wound therapy with instillation in dermatology

Müller

Burgard

Zimmerman

et al. 2016

J Deutsche Derma Gesell

View full text Add to dashboard Cite

SummaryMethods used in the treatment of acute and chronic wounds undergo constant evolution, reevaluation, and innovation. While negative-pressure wound therapy (NPWT) is an established treatment modality, the combination of NPWT and instillation of normal saline as well as solutions with active antiseptic components for topical treatment of the wound bed represents a novel approach. The well-known effects of NPWT may thus be combined with those of local antisepsis. They include a decrease in wound area, induction of granulation tissue, and reduction in bacterial colonization. To date, studies have focused on NPWT with instillation for orthopedic/surgical indications, whereas clinical data in dermatosurgery is limited to case reports or small case series. There are as yet no randomized prospective studies investigating NPWT with instillation in the treatment of skin disorders. The goal of this review is to present the method of NPWT with instillation, to highlight its mode of action as well as possible complications and contraindications, and to review the recent literature. In summary, there is increasing evidence that both simple and complicated wounds may be effectively treated with NPWT with instillation, resulting in markedly accelerated tissue granulation and thus earlier defect closure. Cornelia Sigrid Lissi Limitations of this articleThe fact that there is currently only one supplier (in Germany) of a fully automated device for negative-pressure wound therapy with instillation renders it difficult to present this method in a discriminative manner. Moreover, studies of this treatment modality in defined indications have been rather inadequate. These points limit the objective assessment of this method. Even though the evidence regarding negative-pressure therapy with and without instillation is steadily improving, assessment of this method currently largely depends on the users' personal experience. The objective of this review article on negative-pressure therapy with instillation as a supplementary or alternative method in the treatment of acute and chronic wounds was to present this method along with published data (evidence) and the authors' personal experience. The target audience includes dermatologists with a special interest in dermatosurgery and wound therapy and other physicians who are routinely involved in the management of acute and chronic wounds.

show abstract

“…Renner et al. publizierte 2006 einen umfassenden Überblick über die Anwendung der Vakuum‐assistierten Therapie in der Dermatologie . Große randomisierte Studien zum Vergleich der NPWT mit oder ohne Instillation bei dermatologischen Krankheitsbildern fehlen jedoch völlig.…”

Section: Dermatologische Studienlageunclassified

Zum Stellenwert der Unterdruck‐Instillationstherapie in der Dermatologie

Müller

Burgard

Zimmerman

et al. 2016

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Die Methoden zur Behandlung akuter und chronischer Wunden unterliegen einer steten Weiterentwicklung, Reevaluierung und Anwendung innovativer Therapieformen. Die Vakuumtherapie zur Wundbehandlung gehört zu den etablierten Behandlungsmodalitäten. Ein innovatives Verfahren kombiniert die Vakuumtherapie mit der automatisierten, kontrollierten Zufuhr und Drainage wirkstoffhaltiger Lösungen zur topischen Wundbehandlung im Wundbett und auch wirkstofffrei durch Instillation physiologischer Kochsalzlösung (Unterdruck-Instillationstherapie). Hierdurch können die Effekte der konventionellen Vakuumtherapie mit denen der lokalen Antisepsis kombiniert werden. Hierdurch kommt es zu einer Reduktion der Wundfläche, einer Induktion von Granulationsgewebe sowie einer Reduktion der Keimbesiedelung der Wunden. Bisher publizierte Studien konzentrieren sich auf die Anwendung dieses Therapieverfahrens zur Behandlung orthopädisch-chirurgischer Krankheiten. Die Datenlage bezüglich der Vakuum-Instillationstherapie in der Dermatochirurgie beschränkt sich derzeit auf Fallberichte und Einzelfallerfahrungen. Randomisierte, prospektive Studien zum Vergleich der Vakuum-Instillationstherapie zur Behandlung dermatologischer Krankheitsbilder existieren bislang nicht. Ziele des vorliegenden Artikels sind die Vorstellung der Vakuumtherapie mit Instillation einschließlich ihres Wirkprinzips, deren mögliche Komplikationen, die Diskussion erdenklicher Kontraindikationen sowie eine Übersicht über die aktuell verfügbare Datenlage. Zusammenfassend scheint sich die Evidenz zu verdichten, dass mittels Unterdruck-Instillationstherapie sowohl einfache als auch komplizierte Wunden effizient behandelt werden können, was sich in einer deutlichen Beschleunigung der Wundgranulation mit konsekutiv früher möglichem Defektverschluss äußert.

show abstract

Vacuum therapy in dermatology: a review

Cited by 10 publications

References 23 publications

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

On the significance of negative‐pressure wound therapy with instillation in dermatology

Zum Stellenwert der Unterdruck‐Instillationstherapie in der Dermatologie

Contact Info

Product

Resources

About