Vagal control of the heart: central serotonergic (5‐HT) mechanisms

Jordan, David L.

doi:10.1113/expphysiol.2004.029058

Cited by 127 publications

(97 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because by blocking the reuptake of 5-HT, SRIs induce an increase in extrasynaptic 5-HT availability, the potentially SRI-induced elevation of N300H converges with (a) the general involvement of 5-HT in central control of the heart (Jordan, 2005) and (b) prior findings of a positive relationship between 5-HT and N300H (Mueller et al, 2012;Mueller et al, 2013). Moreover, the effect of SRIs on brain-heart coupling may explain altered heart rate variability in humans with long-term SRI treatments (Licht et al, 2010) and potentiated cardiovascular responses to acute stress in rats with chronic fluoxetine administration (Grippo et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Panic Disorder and Serotonin Reuptake Inhibitors Predict Coupling of Cortical and Cardiac Activity

Mueller

Panitz

Nestoriuc

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Panic attacks, the cardinal symptom of panic disorder (PD), are characterized by intense physiological reactions including accelerated heart activity. Although cortical processes are thought to trigger and potentiate panic attacks, it is unknown whether individuals with PD have a general tendency to show elevated cortico-cardiac interactions, which could predispose them for brain-driven modulations of heart activity during panic. Consistent with this hypothesis, serotonin, a highly relevant neurotransmitter for panic and PD presumably affects the cortical control of the heart. The current study thus aimed to test whether PD and serotonin reuptake inhibitor (SRI) intake are related to corticocardiac interactions in the absence of acute panic. Human participants with PD (n ¼ 22), major depression (MD, clinical control group, n ¼ 21) or no psychiatric diagnosis (healthy control group, n ¼ 23) performed a gambling task. To measure cortico-cardiac coupling, the within-subject covariation of single-trial EEG after feedback presentation and subsequent changes in heart period was determined. As in prior studies, there was a significant time-lagged covariation of EEG and heart activity indicating that trial-by-trial fluctuations of feedback-evoked EEG amplitude determined how much heart activity accelerated seconds later. Importantly, this covariation pattern was significantly potentiated in PD vs control participants. Moreover, concurrent SRI intake further augmented brain-heart covariation in individuals with PD and MD. The present findings demonstrate that PD and serotonin are associated with altered brain-heart interactions in a non-panic situation. Future work should clarify whether brain-heart coupling has a causal role in PD, for example by facilitating panic attacks.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Finally, there is evidence for a prominent role of serotonin (5-HT) in both, brain-heart communication (Jordan, 2005;Mueller et al, 2012;Mueller et al, 2013) and PD (Neumeister et al, 2004). Because serotonin reuptake inhibitors (SRIs) are commonly prescribed for PD and MD, we tested whether current SRI intake correlates with N300H.…”

Section: Introductionmentioning

confidence: 99%

Panic Disorder and Serotonin Reuptake Inhibitors Predict Coupling of Cortical and Cardiac Activity

Mueller

Panitz

Nestoriuc

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…For 5HT, human data strongly implicate it in anxiety and depression, aggressive behaviour, control of appetite and also, more recently, in schizophrenia (Gonzalez-Maeso et al 2008) and Parkinson's disease (Caretti et al 2008). In animal studies, 5HT has also been demonstrated to play a role in central control of pain (reviewed in Suzuki et al 2004;Rice & Hill 2006;Hamel 2007) and sympathetic outflow (Howe 1985;Jordan 2005; reviewed in Coote 1990). Both monoamines are also implicated in various aspects of drug abuse.…”

Section: Introductionmentioning

confidence: 99%

The use of viral gene transfer in studies of brainstem noradrenergic and serotonergic neurons

Kasparov

Teschemacher²

2009

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

In contrast to some other neuronal populations, for example hippocampal or cortical pyramidal neurons, mechanisms of synaptic integration and transmitter release in central neurons that contain noradrenaline (NA) and serotonin (5HT) are not well understood. These cells, crucial for a wide range of autonomic and behavioural processes, have long un-myelinated axons with hundreds of varicosities where transmitters are synthesized and released. Both seem to signal mostly in 'volume transmission' mode. Very little is known about the rules that apply to this type of transmission in the brain and the factors that regulate the release of NA and 5HT. We discuss some of our published studies and more recent experiments in which viral vectors were used to investigate the physiology of these neuronal populations. We also focus on currently unresolved issues concerning the mechanism of volume transmission by NA and 5HT in the brain. We suggest that clarifying the role of astroglia in this process could be essential for our understanding of central noradrenergic and 5HT signalling.

show abstract

“…Studies using similar protocols (atenololpretreated animals) have suggested that the excitation of central circuits involved in the control of the cardiac vagal motoneurons involves the activation of 5-HT 1A (4), 5-HT 2C (8), 5-HT 3 (9), and 5-HT 7 (10) receptors. This is an issue which has already been extensively reviewed (1,11,12). Most of the existing studies have concentrated on the sympathetic activity of the subtypes of 5-HT 2 receptors (5-HT 2A , 5-HT 2B , and 5-HT 2C ) in the regulation of cardiovascular activity (1).…”

mentioning

confidence: 99%

“…It has been reported that non-selective centrally acting 5-HT 2 receptor antagonists reduce blood pressure in normotensive (13) and hypertensive (14) rats, with negligible effects on baseline heart rate. Although studies on the 5-HT 2A receptors, particularly involving the nucleus ambiguus (main source of the cardiac vagal motoneurons) in reflex situations are scarce (1,12), there are a few studies on the role of subtypes of 5-HT 2 receptors in the excitability of the cardiac vagal motoneurons in phasic situations (i.e., cardiovascular reflexes, including the BJR). These studies have provided some evidence that the 5-HT 2B receptors excite while the 5-HT 2C receptors inhibit the neurons of the nucleus tractus solitarii (NTS) (1,8,12,15).…”

mentioning

confidence: 99%

Central 5-HT2A receptors modulate the vagal bradycardia in response to activation of the von Bezold-Jarisch reflex in anesthetized rats

Neto

Macêdo

Silva

et al. 2011

Braz J Med Biol Res

View full text Add to dashboard Cite

Vagal control of the heart: central serotonergic (5‐HT) mechanisms

Cited by 127 publications

References 52 publications

Panic Disorder and Serotonin Reuptake Inhibitors Predict Coupling of Cortical and Cardiac Activity

Panic Disorder and Serotonin Reuptake Inhibitors Predict Coupling of Cortical and Cardiac Activity

The use of viral gene transfer in studies of brainstem noradrenergic and serotonergic neurons

Central 5-HT2A receptors modulate the vagal bradycardia in response to activation of the von Bezold-Jarisch reflex in anesthetized rats

Contact Info

Product

Resources

About