Vagal efferent stimulation protects against Mesobuthus tamulus venom-induced acute respiratory distress syndrome in rats

Akella, Aparna; Deshpande, Shripad B.

doi:10.1016/j.toxicon.2015.10.013

Cited by 10 publications

(13 citation statements)

References 32 publications

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“…Laboratory research demonstrated VNS lung protective effects (Krzyzaniak et al, 2011 ). VNS protected against Mesobuthus tamulus venom-induced ARDS in rats, improving parameters like respiratory alterations, hypoxemia, pulmonary edema and histopathological changes (Akella and Deshpande, 2015 ). It attenuated acute lung injury following burn via the anti-inflammatory pathways (Krzyzaniak et al, 2011 ) and improved the pulmonary function of acute lung injury while counterbalancing the predominance of the sympathetic nervous system (Liu et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

“…Our hypotheses on the therapeutic effects of VNS-induced parasympathetic activity are supported by a wide range of state-of-the-art clinical and experimental data: decrease of pro-inflammatory cytokines and modulation of lung injuries by activation of the anti-inflammatory pathways, improvement of pulmonary and cardiac functions by adjusting the sympatho-vagal imbalance, etc. (Dos Santos et al, 2011 ; Krzyzaniak et al, 2011 ; Kessler et al, 2012 ; Kox et al, 2012 ; Levy et al, 2012 ; Reys et al, 2013 ; Tarras et al, 2013 ; Shinlapawittayatorn et al, 2014 ; Akella and Deshpande, 2015 ; Chen et al, 2016 ; Stavrakis and Po, 2016 ; Liu et al, 2017 ; Huang et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

“…Covid-19 patients present increased levels of IL-1, IL-2, IL-4, IL-7, IL-10, IL-12, IL-13, IL-17, GCSF, MCSF, IP-10, MCP-1, MIP-1α, HGF, IFN-γ, and TNF-α (Guo et al, 2020 ). Vagal afferents in the lungs detect inflammatory tissue-damaging stimuli (Carr and Undem, 2003 ), while VNS reduces the storm of pro-inflammatory cytokines through ChAP and HPAA activation, without leading to immunosuppression (Dos Santos et al, 2011 ; Krzyzaniak et al, 2011 ; Akella and Deshpande, 2015 ; Huang et al, 2019 ). Consequently, we expect VNS to reduce the severity of Covid-19 inflammation-related complications and fatalities while preventing strong and deteriorating immune responses.…”

Section: Methodsmentioning

confidence: 99%

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Non-invasive Auricular Vagus Nerve Stimulation as a Potential Treatment for Covid19-Originated Acute Respiratory Distress Syndrome

Kaniušas

Széles

Kampusch³

et al. 2020

Front. Physiol.

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Background: Covid-19 is an infectious disease caused by an invasion of the alveolar epithelial cells by coronavirus 19. The most severe outcome of the disease is the Acute Respiratory Distress Syndrome (ARDS) combined with hypoxemia and cardiovascular damage. ARDS and co-morbidities are associated with inflammatory cytokine storms, sympathetic hyperactivity, and respiratory dysfunction. Hypothesis: In the present paper, we present and justify a novel potential treatment for Covid19-originated ARDS and associated co-morbidities, based on the non-invasive stimulation of the auricular branch of the vagus nerve. Methods: Auricular vagus nerve stimulation activates the parasympathetic system including anti-inflammatory pathways (the cholinergic anti-inflammatory pathway and the hypothalamic pituitary adrenal axis) while regulating the abnormal sympatho-vagal balance and improving respiratory control. Results: Along the paper (1) we expose the role of the parasympathetic system and the vagus nerve in the control of inflammatory processes (2) we formulate our physiological and methodological hypotheses (3) we provide a large body of clinical and preclinical data that support the favorable effects of auricular vagus nerve stimulation in inflammation, sympatho-vagal balance as well as in respiratory and cardiac ailments, and (4) we list the (few) possible collateral effects of the treatment. Finally, we discuss auricular vagus nerve stimulation protective potential, especially in the elderly and co-morbid population with already reduced parasympathetic response. Conclusions: Auricular vagus nerve stimulation is a safe clinical procedure and it could be either an effective treatment for ARDS originated by Covid-19 and similar viruses or a supplementary treatment to actual ARDS therapeutic approaches.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Non-invasive Auricular Vagus Nerve Stimulation as a Potential Treatment for Covid19-Originated Acute Respiratory Distress Syndrome

Kaniušas

Széles

Kampusch³

et al. 2020

Front. Physiol.

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“…Moreover, VNS has been shown to inhibit NF-κB action (Guarini et al 2003 ). In a preclinical study, VNS was proven to prevent ARDS development, after scorpion poison (mesobuthus tamulus) had been administered (Akella and Deshpande 2015 ).…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

Autonomic balance determines the severity of COVID-19 courses

et al. 2020

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COVID-19 has left mankind desperately seeking how to manage dramatically rising infection rates associated with severe disease progressions. COVID-19 courses range from mild symptoms up to multiple organ failure and death, triggered by excessively high serum cytokine levels (IL 1β, IL 6, TNF α, IL 8). The vagally driven cholinergic anti-inflammatory pathway (CAP) stops the action of nuclear factor κB (NF-κB), the transcriptional factor of pro-inflammatory cytokines. Thus, well-balanced cytokine release depends on adequate vagal signaling. Coronaviruses replicate using NF-κB transcriptional factor as well. By degrading the cytoplasmatic inhibitor of NF-κB subunits (IκB), coronaviruses induce unrestricted NF-κB expression accelerating both, virus replication and cytokine transcription.We hypothesize that CAP detriment due to depressed vagal tone critically determines the severity of COVID-19.

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“…Vagal efferent stimulation can protect against Mesobuthus tamulus venom-induced ARDS through anti-inflammatory mechanism [6]. The regulatory influence of the efferent vagus nerve on expression of pro-inflammatory cytokines is mediated through the cholinergic antiinflammatory route which involves α7nAChR-dependent signal cascade [7].…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

Galantamine protects against hydrochloric acid aspirationinduced acute respiratory distress syndrome in rabbits

Yang¹,

Peng²,

Yang³

2018

Trop. J. Pharm Res

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Vagal efferent stimulation protects against Mesobuthus tamulus venom-induced acute respiratory distress syndrome in rats

Cited by 10 publications

References 32 publications

Non-invasive Auricular Vagus Nerve Stimulation as a Potential Treatment for Covid19-Originated Acute Respiratory Distress Syndrome

Non-invasive Auricular Vagus Nerve Stimulation as a Potential Treatment for Covid19-Originated Acute Respiratory Distress Syndrome

Autonomic balance determines the severity of COVID-19 courses

Galantamine protects against hydrochloric acid aspirationinduced acute respiratory distress syndrome in rabbits

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