Vagal Nerve Activity Recording in the Awake Condition for the Control of an Artificial Heart System

Yambe, Tomoyuki; Nanka, S.; Kobayashi, Shinichi; Yoshizawa, Makoto; Abe, Kenichi; Tabayashi, K; Takeda, Hiroshi; Nitta, S.

doi:10.1046/j.1525-1594.1999.06396.x

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…This shows the implantable part of the UPVAD system. The control logic was developed in the University of Tokyo, and the detailed algorithm was designed in Tohoku University (13,14). The implantable IC system was made at Research Center for Advanced Science and Technology (RCAST) in the University of Tokyo.…”

Section: Implantable Undulation Pump Ventricular Assist Devicementioning

confidence: 99%

Development of an Implantable Undulation Type Ventricular Assist Device for Control of Organ Circulation

et al. 2004

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It is well known that a rotary blood pump (RP) is effective as a small ventricular assist device (VAD). It might be still more effective if pulsation was available. The undulation pump (UP), which is a type of small RP, can also produce pulsation. In Japan, a development project for an implantable type UP ventricular assist device (UPVAD) is now advanced. Six universities and some companies together have been in charge of the development project for 5 years. In this study, the influence which the UP under development has on circulation in internal organs was investigated. Goats with the same weight as an average Asian person were used for the experiment. The left chest cavity was opened after resection of the fourth rib and the heart was approached. A cannula was inserted in the left ventricle from the apex. An outflow cannula was inserted into the left descending aorta. Heart muscle was excised using a newly developed puncher. The UPVAD was implanted using a left-heart bypass system. The myocardial blood flow, carotid arterial blood flow, and the kidney blood flow were recorded together with an electrocardiogram, blood pressure, and the flow rate. In these animal experiments, the blood circulation dynamic state was stabilized and sufficient support of the left heart was observed. Myocardial blood flow, carotid arterial flow, and a kidney blood flow increase resulting from UPVAD support was observed. Often the problem of multiple organ failure is important at the time of clinical application of a ventricular assist device. Assisting circulation to internal organs is important for prevention of multiple organ failure. It was concluded that the UPVAD might be useful for prevention of multiple organ failure.

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Section: Implantable Undulation Pump Ventricular Assist Devicementioning

confidence: 99%

Development of an Implantable Undulation Type Ventricular Assist Device for Control of Organ Circulation

et al. 2004

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What have we learned about the contribution of autonomic nervous system to human arrhythmia?

et al. 2009

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Recording Vagal Nerve Activity for the Control of an Artificial Heart System

Yambe

Nanka²,

Shiraishi³

et al. 2003

ASAIO Journal

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Monitoring cardiovascular control system information is important in considering the quality of life (QOL) of patients with artificial hearts. Natural heart circulation is controlled by an autonomic nervous system. Therefore, it is desirable to record autonomic nerve activity for the control of artificial heart systems. We directly recorded vagal nerve activity in long-term animal experiments. Six healthy adult goats were anesthetized with halothane inhalation, and thoracotomy was performed with the fourth rib resection during mechanical ventilation. Arterial blood pressure and right and left atrial pressures were continuously monitored with an inserted catheter. Cardiac output was measured by an electromagnetic flow meter attached to the ascending aorta. After the chest was closed, an incision was made in the left neck, and the left vagal nerve was separated. Stainless steel electrodes were inserted into the vagal nerve and fixed by a plasticizer. After the incision was closed, the goats were transferred to a cage and extubated after waking. Vagal nerve activity was measured using hemodynamic parameters when the animals were awake. Our results show that clear observation of autonomic nerve discharge was made through this experimental system for over 1 month. The tonus of the vagal nerve was significantly altered before body motion with hemodynamic changes, suggesting the possibility of prediction. These results suggest that information from autonomic nerves may help to control implantable artificial hearts or ventricular assist devices.

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Vagal Nerve Activity Recording in the Awake Condition for the Control of an Artificial Heart System

Cited by 3 publications

References 16 publications

Development of an Implantable Undulation Type Ventricular Assist Device for Control of Organ Circulation

Development of an Implantable Undulation Type Ventricular Assist Device for Control of Organ Circulation

What have we learned about the contribution of autonomic nervous system to human arrhythmia?

Recording Vagal Nerve Activity for the Control of an Artificial Heart System

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