Vagal nerve stimulation is effective in pre-school children with intractable epilepsy: A report of two cases

Zhao, Yang; Zhang, Ciliu; Wang, Zhiyan; Cheng, Tung-Yang; Qin, Xiaoya; Deng, Jin; Fang, Xi; Hao, Hongwei; Peng, Jing; Yin, Fei; Li, Luming

doi:10.26599/jnr.2020.9040017

Cited by 3 publications

(2 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is generally acknowledged that epilepsy surgery and neuromodulation surgery are effective therapies to treat refractory epilepsy [3,4]. Recent studies have shown that neurostimulation has also become one of the effective therapies for refractory epilepsy [5,6].…”

Section: Introductionmentioning

confidence: 99%

Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

et al. 2023

View full text Add to dashboard Cite

Objective Studies have shown that obesity has a significant impact on poor surgical outcomes. However, the relationship between obesity and pediatric epilepsy surgery has not been reported. This study aimed to explore the relationship between obesity and complications of pediatric epilepsy surgery and the effect of obesity on the outcome of pediatric epilepsy surgery, and to provide a reference for weight management of children with epilepsy. Methods A single-center retrospective analysis of complications in children undergoing epilepsy surgery was conducted. Body mass index (BMI) percentiles were adjusted by age and used as a criterion for assessing obesity in children. According to the adjusted BMI value, the children were divided into the obese group (n = 16) and nonobese group (n = 20). The intraoperative blood loss, operation time, and postoperative fever were compared between the two groups. Results A total of 36 children were included in the study, including 20 girls and 16 boys. The mean age of the children was 8.0 years old, ranging from 0.8 to 16.9 years old. The mean BMI was 18.1 kg/m2, ranging from 12.4 kg/m2 to 28.3 kg/m2. Sixteen of them were overweight or obese (44.4%). Obesity was associated with higher intraoperative blood loss in children with epilepsy (p = 0.04), and there was no correlation between obesity and operation time (p = 0.21). Obese children had a greater risk of postoperative fever (56.3%) than nonobese children (55.0%), but this was statistically nonsignificant (p = 0.61). The long-term follow-up outcomes showed that 23 patients (63.9%) were seizure-free (Engel grade I), 6 patients (16.7%) had Engel grade II, and 7 patients (19.4%) had Engel grade III. There was no difference in long-term seizure control outcomes between obese and nonobese groups (p = 0.682). There were no permanent neurological complications after surgery. Conclusion Compared with nonobese children with epilepsy, obese children with epilepsy had a higher intraoperative blood loss. It is necessary to conduct early weight management of children with epilepsy as long as possible.

show abstract

Section: Introductionmentioning

confidence: 99%

Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Focal cortical dysplasia (FCD) is a specific cortical malformation occurred during the development and represents the most prevalent etiology of medically intractable epilepsy in children, leading to surgical resection of the lesions or neurostimulation treatment ultimately [1,2]. FCD is classified into type I and type II according to the current international consensus classification by ILAE [3].…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor‐C modulates cortical NMDA receptor activity in cortical lesions of young patients and rat model with focal cortical dysplasia

Shen

Duan

et al. 2022

Brain Pathology

View full text Add to dashboard Cite

Emergence of dysmorphic neurons is the primary pathology in focal cortical dysplasia (FCD) associated pediatric intractable epilepsy; however, the etiologies related to the development and function of dysmorphic neurons are not fully understood. Our previous studies revealed that the expression of vascular endothelial growth factor‐C (VEGF‐C) and corresponding receptors VEGFR‐2, VEGFR‐3 was increased in the epileptic lesions of patients with tuberous sclerosis complex or mesial temporal lobe epilepsy. Here, we showed that the expression of VEGF‐C, VEGFR‐2, and VEGFR‐3 was increased at both mRNA and protein levels in patients with cortical lesions of type I, IIa, and IIb FCD. The immunoreactivity of VEGF‐C, VEGFR‐2 and VEGFR‐3 was located in the micro‐columnar neurons in FCD type I lesions, dysplastic neurons (DNs) in FCD type IIa lesions, balloon cells (BCs) and astrocytes in FCD type IIb lesions. Additionally, the amplitude of evoked‐EPSCs (eEPSC) mediated by NMDA receptor, the ratio of NMDA receptor‐ and AMPA receptor‐mediated eEPSC were increased in the dysmorphic neurons of FCD rats established by prenatal X‐ray radiation. Furthermore, NMDA receptor mediated current in dysmorphic neurons was further potentiated by exogenous administration of VEGF‐C, however, could be antagonized by ki8751, the blocker of VEGFR‐2. These results suggest that VEGF‐C system participate in the pathogenesis of cortical lesions in patients with FCD in association with modulating NMDA receptor–mediated currents.

show abstract

Vagus nerve stimulation and heart rate variability: A scoping review of a somatic oscillatory signal

Wessel,

Karakas,

Haneef

et al. 2024

Clinical Neurophysiology

View full text Add to dashboard Cite

Vagal nerve stimulation is effective in pre-school children with intractable epilepsy: A report of two cases

Cited by 3 publications

References 25 publications

Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

Study on the relationship between obesity and complications of Pediatric Epilepsy surgery

Vascular endothelial growth factor‐C modulates cortical NMDA receptor activity in cortical lesions of young patients and rat model with focal cortical dysplasia

Vagus nerve stimulation and heart rate variability: A scoping review of a somatic oscillatory signal

Contact Info

Product

Resources

About