Vagal stimulation and somatostatin potentiate cardiac vagal action in the toad, Bufo marinus

Preston, Elaine; Courtice, Gillian P.

doi:10.1016/0304-3940(92)90572-o

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…have deterrent effects on the ants' ability to cut their leaves; they are a common reservoir of bufanolids (Whittaker & Feeny, 1971). These compounds are well known iontropic agents which interfere with the metabolism of sodium and calcium within the nervous system (Preston & Courtice, 1992). Bufanolid-poisoned mammals are usually driven to inappetence (lack of appetite) and considering that the insects have a well-developed central nervous system, almost comparable to that of mammals (Matsumura, 1976), it is reasonable to suppose that the workers of A. s. rubropilosa were able to recognize and avoid the leaves with the neurotoxic agent.…”

Section: Discussionmentioning

confidence: 99%

Assessment of the behaviour patterns of the lemon leaf-cutting ant, Atta sexdens rubropilosa (Hymenoptera: Formicidae), to natural sources of allelochemicals

Sales

1994

Bull. Entomol. Res.

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Reactions of the lemon leaf-cutting ant, Atta sexdens rubropilosa Forel, to natural sources of allelochemicals has been investigated at the University of Southampton. A linear hypothesis model in a randomized block design of a factorial experiment was utilized to assess the responses of the ants to the treatment combinations. When workers were offered flowers and leaves of the specified plant species simultaneously with mesocarp and endocarp of orange, they exhibited a consistent preference for the flowers. Flower fragments comprised 93.64% of the experimental material brought to the nest, leaves 6.20%, orange mesocarp 0.04% and orange endocarp 0.12%. Deterrent effects were noticed in leaves of Scilla spp. (Liliaceae) and the ants were chemically stimulated to explore, cut and transport the highly attractive flowers of Mahonia aquifolium (Berberidaceae).

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Section: Discussionmentioning

confidence: 99%

Assessment of the behaviour patterns of the lemon leaf-cutting ant, Atta sexdens rubropilosa (Hymenoptera: Formicidae), to natural sources of allelochemicals

Sales

1994

Bull. Entomol. Res.

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“…Within the cardiovascular system, SRIF exerts receptor-mediated effects on cardiac function [45,46] via actions on cardiac muscle excitability and the control of ion channel activity [47]. Past studies have shown that within the heart, SRIF's main effects are to decrease heart rate [48][49][50], reduce cardiac muscle contractility [48][49][50], and increase atrioventricular conduction time [48,50]. SRIF coexists with acetylcholine in vagal nerve endings [19,48].…”

Section: Cardiac Effectsmentioning

confidence: 99%

“…Past studies have shown that within the heart, SRIF's main effects are to decrease heart rate [48][49][50], reduce cardiac muscle contractility [48][49][50], and increase atrioventricular conduction time [48,50]. SRIF coexists with acetylcholine in vagal nerve endings [19,48]. Therefore, SRIF plays a role in cardiac rhythmogenicity by modifying the electrophysiological properties of the sinoatrial and atrioventricular nodes, which are innervated by somatostatinergic neurons [19].…”

Section: Cardiac Effectsmentioning

confidence: 99%

Somatostatin: A Hormone for the Heart?

Badway

Blake²

2005

CVP

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Somatostatin (somatotropin release inhibitory factor; SRIF) peptides are widely distributed throughout the mammalian body and act through a family of genetically distinct, guanine nucleotide regulatory protein coupled (G-protein-coupled), cell surface receptors (sst(1-5)). Compelling evidence shows that SRIF and SRIF peptidyl analogs modulate vascular function, with actions upon smooth muscle and endothelium. SRIF receptors are known to exist in the carotid endothelium, a principal target for the pro-inflammatory cascade that accompanies coronary artery disease. SRIF-14 and SRIF analogs are anti-inflammatory but the molecular mechanism involved remains unclear. Since crucial steps in the endothelial inflammation response include endothelial activation by cytokines, adhesion molecule expression and cell-monocyte interactions, peptide agents that inhibit these steps might provide a novel strategy for reducing vascular inflammation. SRIF, acting through its cognate receptors, modulates a variety of intracellular effectors that are linked to inflammation including phosphotyrosine phosphatases, the extracellular regulated protein kinase 1 and 2 (ERK1/2) cascade, adenylyl cyclase and endothelial nitric oxide synthase. Directly or indirectly, SRIF also functions to inhibit endothelial cell proliferation and induce apoptosis. A detailed understanding of SRIF actions could provide a rational basis for using SRIF ligands in controlling vascular inflammation and inhibiting cytokine signaling, critical events in atherogenesis.

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“…38 Υποστηρίζεται μάλιστα ότι η σωματοστατίνη εκλύεται από τις τελικές απολήξεις του πνευμονογαστρικού στο μυοκάρδιο μετά από υψήσυχνο ερεθισμό (10 Hz) και επιτείνει την βαγοτονική δράση του με προσυναπτική δράση. 39 Πιθανότατα καταστέλλει το τονικό σκέλος του χρονότροπου αποτελέσματος του πνευμονογαστρικού 40 και επιτείνει το συγχρονιστικό σκέλος. 41 Στον άνθρωπο έχουν εντοπιστεί περιοχές στον φλεβόκομβο, τον κολποκοιλιακό κόμβο και το δεξιό κόλπο που περιέχουν σωματοστατίνη.…”

Section: επίδραση στη συμπαθητική και παρασυμπαθητική νεύρωση του μυοκαρδίουunclassified

Κυκλοφορικές Μεταβολές Από Τη Χορήγηση Φυσικής Σωματοστατίνης Και Του Ανάλογου Αυτής Σαντοστατίνης Κατά Τη Μετεγχειρητική Περίοδο

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Vagal stimulation and somatostatin potentiate cardiac vagal action in the toad, Bufo marinus

Cited by 8 publications

References 20 publications

Assessment of the behaviour patterns of the lemon leaf-cutting ant, Atta sexdens rubropilosa (Hymenoptera: Formicidae), to natural sources of allelochemicals

Assessment of the behaviour patterns of the lemon leaf-cutting ant, Atta sexdens rubropilosa (Hymenoptera: Formicidae), to natural sources of allelochemicals

Somatostatin: A Hormone for the Heart?

Κυκλοφορικές Μεταβολές Από Τη Χορήγηση Φυσικής Σωματοστατίνης Και Του Ανάλογου Αυτής Σαντοστατίνης Κατά Τη Μετεγχειρητική Περίοδο

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