Vagally mediated release of gastrin and cholecystokinin following sensory stimulation

Uvnäs-Moberg, K; Lundeberg, Thomas; Bruzelius, G.; Alster, Pawel

doi:10.1111/j.1748-1716.1992.tb09429.x

Cited by 38 publications

(15 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have begun exploring the effects of acupuncture on gastrointestinal physiolog y and its potential for the treatment of g astrointestinal diseases [2,[20][21][22] . However, despite its well-known effects on nausea and vomiting, relatively little attention has been paid to its potential for the management of disorders of gastrointestinal motility [13,14] .…”

Section: Discussionmentioning

confidence: 99%

Effective regularity in modulation on gastric motility induced by different acupoint stimulation

Zhu²,

Rong³

et al. 2006

WJG

View full text Add to dashboard Cite

AIM:To investigate whether manual acupuncture at representative acupoints in different parts of the body can modulate responses of gastric motility in rats and regular effects in different acupoint stimulation. METHODS:The gastric motor activity of rats was recorded by the intrapyloric balloon. The changes of gastric motility induced by the stimulation were compared with the background activity in intragastric pressure and/or waves of gastric contraction recorded before any stimulation. Morphological study was also conducted by observing the Evans dye extravasation in the skin after mustard oil injection into the intragastric mucous membrane to certify cutaneous innervations of blue dots related to gastric segmental innervations. RESULTS:In all six rats that received mustard oil injections into intragastric mucosa, small blue dots appeared in the skin over the whole abdomen, but mainly in peri-midline upper-and middle-abdomen and middle-back, a few in thigh and groin. It may speculate that cutaneous innervations of blue dots have the same distribution as gastric segmental innervations. Acustimulation in acupoints of head-neck, four limbs, upper chest-dorsum and lower-dorsum induced markedly augmentation of gastric motility (acupoints on head- C O N C L U S I O N :R e g u l a r r e g u l a t o r y e f f e c t s o f facilitation and inhibition on gastric motility appear to be somatotopically organized in the acupoints of whole body, and the effective regularity of site-special acupoints on gastric motility is involved in segmental innervations between stomach and acupoints.

show abstract

Section: Discussionmentioning

confidence: 99%

Effective regularity in modulation on gastric motility induced by different acupoint stimulation

Zhu²,

Rong³

et al. 2006

WJG

View full text Add to dashboard Cite

show abstract

“…It should be mentioned that the vagal regulation of the gastrointestinal and pancreatic hormones is complex. Both inhibitory and stimulatory vagal effects on these hormones have been shown, and the vagal nerve consists of both cholinergic and noncholinergic fibers, often causing opposite effects [5, 24, 25]. …”

Section: Discussionmentioning

confidence: 99%

Long-Term Changes in Gastrin, Cholecystokinin and Insulin in Response to Oxytocin Treatment

et al. 1999

View full text Add to dashboard Cite

The present study was designed to investigate how repeated injections of oxytocin influence plasma levels of vagally controlled hormones such as gastrin, cholecystokinin (CCK), insulin and somatostatin, as well as of endogenous oxytocin and glucose. Since oxytocin may enhance the activity of centrally located α₂-adrenoreceptors, a second aim of this study was to explore whether these receptors are involved in the effects. For this purpose, oxytocin (1.0 mg/kg) or NaCl was given subcutaneously (s.c.) once a day during 5 days to male rats. Rats were decapitated 1, 3 and 10 days after the last injection, blood was collected and hormone levels were radioimmunoassayed. The oxytocin treatment caused an elevation of plasma levels of oxytocin 1 day (p < 0.05) but not 3 and 10 days after treatment. Gastrin levels were decreased on day 1, 3 and 10 (ANOVA; p < 0.01). In addition, both insulin and CCK levels were decreased in response to the oxytocin treatment when measured 3 and 10 days after the last injection (ANOVA; insulin p < 0.01, CCK p < 0.05). When the α₂-adrenoreceptor agonist clonidine (2.5 µg/kg intracerebroventricularly) was administered 3 days after the 5-day treatment period with oxytocin or saline, plasma levels of insulin and CCK increased significantly (p < 0.05) in the oxytocin-treated rats, when compared to saline-treated controls receiving clonidine only. No change in glucose or somatostatin levels was found in response to the oxytocin treatment. In conclusion, these results show that oxytocin induces long-lasting changes in plasma levels of gastrin, CCK and insulin, without affecting somatostatin or glucose levels. These effects may be mediated by changes in vagal nerve activity.

show abstract

“…It further increases oxytocin levels and influences the levels of gastrointestinal hormones, as a consequence of efferent vagal nerve activation (Kurosawa et al 1982;Araki et al 1984;Stock and Uvnäs-Moberg 1988;Uvnäs-Moberg et al 1992;Kurosawa et al 1995). In unanesthetized rats, both physiological and behavioral effects are induced by non-noxious sensory stimulation.…”

mentioning

confidence: 99%

Short-Term Interaction between Dogs and Their Owners: Effects on Oxytocin, Cortisol, Insulin and Heart Rate—An Exploratory Study

et al. 2011

View full text Add to dashboard Cite

The aim of this exploratory study was to determine heart rate and the levels of oxytocin, cortisol, and insulin in dogs and their owners in response to a short-term interaction. In addition, the dogs' behavior was studied. The owners' responses were compared with those obtained from a control group. Ten female volunteers and their own male Labrador dogs participated in an experiment during which the owner stroked, petted, and talked with her dog during the first 3 minutes. Blood samples were collected from both dog and owner before (0) and at 1, 3, 5, 15, 30, and 60 minutes after the start of the interaction. Blood samples were analyzed by EIA. Heart rate was monitored telemetrically. The data were analyzed using linear mixed models and paired t-tests. The dogs' oxytocin levels were significantly increased 3 minutes after the start of the interaction (p = 0.027). Cortisol levels were significantly increased after 15 and 30 minutes (p = 0.004 and p = 0.022, respectively), and heart rate was significantly decreased after 55 minutes (p = 0.008). The dogs displayed normal behaviors during the experiment. The owners' oxytocin levels peaked between 1 and 5 minutes after interaction (p = 0.026). No such effect was seen in the controls. Cortisol levels displayed a significant decrease at 15 or 30 minutes in both owners and controls, and insulin levels did so at 60 minutes (p = 0.030, p = 0.002 and p = 0.002, 301 Anthrozoös Anthrozoös Short-Term Interaction between Dogs and Their Owners… p < 0.0001, respectively). Heart rate decreased significantly in the owners at 55 and 60 minutes (p = 0.0008) but not in the controls. In conclusion, short-term sensory interaction between dogs and their owners influences hormonal levels and heart rate. However, further studies need to be performed in order to better understand the effects of interaction between dogs and their owners.

show abstract

Vagally mediated release of gastrin and cholecystokinin following sensory stimulation

Cited by 38 publications

References 17 publications

Effective regularity in modulation on gastric motility induced by different acupoint stimulation

Effective regularity in modulation on gastric motility induced by different acupoint stimulation

Long-Term Changes in Gastrin, Cholecystokinin and Insulin in Response to Oxytocin Treatment

Short-Term Interaction between Dogs and Their Owners: Effects on Oxytocin, Cortisol, Insulin and Heart Rate—An Exploratory Study

Contact Info

Product

Resources

About