Vaginal and oral probiotics effect in the prevention of preterm delivery in patients visiting Kamali Hospital, Karaj, Iran in 2020

Solgi, Elahe; Tavakoli‐Far, Bahareh; Badehnoosh, Bita; Khavandegar, Armin; Bakhtiyari, Mahmood

doi:10.1016/j.eurox.2022.100169

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…This observational study provided substantial evidence for a relation between the timing of probiotic milk intake throughout gestation and the prevalence of preterm delivery [ 36 ]. In addition, probiotic use ( Lactobacillus acidophilus , Lactobacillus plantarum , Lactobacillus frementum , and Lactobacillus gasseri ) daily in 185 pregnant women with a gestational age higher than or equal to the 25th week did not elevate the frequency of preterm birth nor decrease the duration of gestation; however, the frequency of preterm birth was reduced in the oral probiotics group [ 71 ]. In this context, a retrospective study assessed the frequency of recurrent spontaneous preterm delivery in pregnant women who received probiotics containing Clostridium butyricum , Enterococcus faecium , and Bacillus subtilis [ 72 ].…”

Section: Resultsmentioning

confidence: 99%

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Poulios,

Pavlidou,

Papadopoulou

et al. 2024

Biology

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Background: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics’ healthy effects are related with the prevention of many diseases, as well as decreasing symptom severity. Currently, the most available data concerning their potential health effects are associated with metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may exert beneficial effects against diverse adverse pregnancy outcomes. The purpose of the current narrative study is to extensively review and analyze the current existing clinical studies concerning the probable positive impacts of probiotics supplementation during pregnancy as a protective agent against adverse pregnancy outcomes beyond gestational diabetes mellitus. Methods: a comprehensive and thorough literature search was conducted in the most precise scientific databases, such as PubMed, Scopus, and Web of Sciences, utilizing efficient, representative, and appropriate keywords. Results: in the last few years, recent research has been conducted concerning the potential beneficial effects against several adverse pregnancy outcomes such as lipid metabolism dysregulation, gestational hypertensive disorders, preterm birth, excessive gestational weight gain, caesarean risk section, vaginal microbiota impairment, mental health disturbances, and others. Conclusion: up to the present day, there is only preliminary clinical data and not conclusive results for probiotics’ healthy effects during pregnancy, and it remains questionable whether they could be used as supplementary treatment against adverse pregnancy outcomes beyond gestational diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Poulios,

Pavlidou,

Papadopoulou

et al. 2024

Biology

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“…Like ours, all other studies that have been published to date have been too small to demonstrate effectiveness of this intervention in the prevention of PTB. One randomized controlled trial analyzed the effect of probiotics on the occurrence of PTB and failed to show any effect, possibly because of low power [ 11 ]. Moreover, one of the reviews [ 12 ] also identified no evidence that taking probiotics or prebiotics during pregnancy either increases or decreases the risk of preterm birth or other infant and maternal adverse pregnancy outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…However, the effect of probiotic on pregnancy outcome mainly PTB is not well recognized. One study found probiotic use did not increase the rate of preterm delivery and duration of pregnancy compared with placebo [ 11 ]. One of the reviews [ 12 ] also identified no evidence that taking probiotics or prebiotics during pregnancy either increases or decreases the risk of preterm birth or other infant and maternal adverse pregnancy outcomes.…”

Section: Introductionmentioning

confidence: 99%

Pregnancy outcomes in pregnant women taking oral probiotic undergoing cerclage compared to placebo: two blinded randomized controlled trial

Vanda,

Dastani,

Taghavi

et al. 2024

BMC Pregnancy Childbirth

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Aim The purpose of this study is to evaluate the oral probiotic effect on pregnancy outcomes in pregnant women undergoing cerclage compared to placebo. Methods This study was a double-blind randomized clinical trial undertaken in Yasuj, Iran. 114 eligible participants who have undergone cerclage were randomly divided to either receive probiotic adjuvant or 17α-OHP (250 mg, IM) with placebo from the 16th -37th week of pregnancy by “block” randomization method. Our primary outcomes were preterm labor (PTB) (late and early) and secondary outcomes were other obstetrical and neonatal outcomes included preterm pre-labor rupture of membranes (PPROM), pre-labor rupture of membranes (PROM), mode of delivery, and neonatal outcomes including anthropometric characterize and Apgar score (one and fifth-minute). Results Results show that there are no statistically significant differences between the two groups in terms of PTB in < 34th (15.51% vs. 17.86%; P = 0.73) and 34-37th weeks of pregnancy (8.7% vs. 16.1%; P = 0.22), and mode of delivery (P = 0.09). PPROM (8.7% vs. 28.5%; P = 0.006) PROM (10.3% vs. 25%; P = 0.04) was significantly lower in patients receiving probiotic adjuvant compared to the control group. After delivery, the findings of the present study showed that there were no significant differences in newborn’s weight (3082.46 ± 521.8vs. 2983.89 ± 623.89), head circumstance (36.86 ± 1.53vs. 36.574 ± 1.52), height (45.4 ± 5.34 vs. 47.33 ± 4.92) and Apgar score in one (0.89 ± 0.03 vs. 0.88 ± 0.05) and five minutes (0.99 ± 0.03vs. 0.99 ± 0.03) after birth. Conclusion Our result has shown that the consumption of Lactofem probiotic from the 16th week until 37th of pregnancy can lead to a reduction of complications such as PPROM and PROM.

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“…Пациентки контрольной группы не получали лечения. Согласно результатам, ПР имели место у 28 (26,7%) пациенток контрольной группы, 12 (30%) пациенток второй и 9 (22,5%) пациенток первой группы [8].…”

Section: Introductionunclassified

Modern Treatment of Bacterial Vaginosis in the Second Trimester of Pregnancy

Mammaeva,

Manukhin,

Osmanova

2023

EPh

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Purpose: to assess the effectiveness of modern methods of treatment of patients with BV in the second trimester of pregnancy. Material and methods. The prospective comparative study included 50 patients of the second trimester of pregnancy with BV, which are divided into 2 groups. The first group received clindamycin + Lactoginal at the same time. The second group received the probiotc Lactoginal. Microscopic examination of the vaginal smear and PCR diagnostics were performed in all pregnant women. After treatment, a second study was carried out on the vaginal microflora in pregnant women. Results. According to the results of the study: according to the Amsel criterion, the recovery of patients in group 1 was 88%, in group 2 – 84%. According to the PCR study in group 1 – 80%, in group 2 – 76%. After the therapy, none of the patients noted clinical complaints. In the study groups, in 42 patients, pregnancy ended in timely delivery; caesarean section in 8 patients. Conclusion. The use of a probiotic in pregnant women with BV separately is an alternative method of treatment, favorably affects the entire period of pregnancy, as well as subsequently on delivery

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Vaginal and oral probiotics effect in the prevention of preterm delivery in patients visiting Kamali Hospital, Karaj, Iran in 2020

Cited by 6 publications

References 32 publications

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Pregnancy outcomes in pregnant women taking oral probiotic undergoing cerclage compared to placebo: two blinded randomized controlled trial

Modern Treatment of Bacterial Vaginosis in the Second Trimester of Pregnancy

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