Vaginal application of lactobacilli in the prophylaxis of recurrent lower urinary tract infection in women

Bærheim, Anders; Larsen, Eirik; Digranes, Asbjørn

doi:10.3109/02813439409029247

Cited by 93 publications

(33 citation statements)

References 12 publications

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“…In preliminary, uncontrolled studies, Bruce et al [23] demonstrated reduced UTI attack rates when H 2 O 2 -negative lactobacilli were introduced into the vagina. However, not all investigators have enjoyed similar success [24]. Further studies are needed with large number of subjects and carefully defined and selected Lactobacillus strains.…”

Section: Urinary Tract Infections In Womenmentioning

confidence: 84%

Is there a protective role for vaginal flora?

Sobel

1999

Curr Infect Dis Rep

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The notion of a protective vaginal flora is relatively new. Resident flora manifest colonization resistance to prevent or reduce the likelihood of exogenous microorganisms, viruses, bacteria, yeast, or parasites becoming established in the lower genital tract of women following sexual (HIV, Neisseria gonorrhoeae, Escherichia coli, Candida albicans, Trichomonas vaginalis) or nonsexual (uropathogenic E. coli) transmission. The concept of preserving or reestablishing protective flora has been hastened by several factors, including the potential widespread use of vaginal microbicides, the increased heterosexual spread of HIV, and the imminent availability of exogenous Lactobacillus species probiotic therapy.

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Section: Urinary Tract Infections In Womenmentioning

confidence: 84%

Is there a protective role for vaginal flora?

Sobel

1999

Curr Infect Dis Rep

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“…Reid et al have demonstrated that Lactobacillus vaginal suppositories are safe and may be effective in reducing the recurrence of UTI [10]. Conversely, Baerheim et al have demonstrated that uncertainty exists as to whether the vaginal application of lactobacilli reduces the infection rate in cystitis-prone women [11]. Since the effectiveness of Lactobacillus vaginal suppositories on recurrent UTI is still inconclusive, a prospective clinical study to confirm the safety and effectiveness of Lactobacillus vaginal suppositories against recurrent UTI was performed.…”

Section: Discussionmentioning

confidence: 97%

“…However, the effectiveness of Lactobacillus vaginal suppositories on recurrent UTI is still inconclusive [10,11].…”

Section: Introductionmentioning

confidence: 99%

A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection

Uehara

Monden

Nomoto

et al. 2006

International Journal of Antimicrobial Agents

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Changes in the indigenous vaginal microflora with uropathogenic bacteria can predispose women to frequently recurring bacterial cystitis. Lactobacilli used as probiotics have played an important role in preventing the colonization of pathogenic bacteria in the vagina. A prospective clinical pilot study was performed to confirm the safety and effectiveness of Lactobacillus vaginal suppositories against the recurrence of bacterial urinary tract infection (UTI). The patients enrolled in the study were instructed to administer vaginal suppositories containing the strain Lactobacillus crispatus GAI 98322. A significant reduction in the number of recurrences was noted, without any adverse complication (P=0.0007). The administration of vaginal suppositories containing L. crispatus GAI 98332 seemed to be a safe and promising treatment for the prevention of recurrent UTI.

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“…McGroarty (1993) and Parent et al (1996) outlined some of the characteristics that probiotics for the urogenital tract should have, most of them referring to technological properties. Some experiments and assays reported on the prevention of urinary tract infections (Baerheim et al, 1994;Reid et al, 1992), and others referred to the vaginal tract. Hilton et al (1995) mentioned the use of Lactobacillus GG isolated from the gastrointestinal tract, topically applied to the treatment of recurrent vaginitis.…”

Section: Discussionmentioning

confidence: 99%