Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection

Stade, Brenda; Shah, Vibhuti; Ohlsson, Arne

doi:10.1002/14651858.cd003520.pub2

Cited by 35 publications

(18 citation statements)

References 35 publications

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“…Previous Cochrane reviews have only assessed the eff ect of important preventive interventions such as intrapartum antibiotic prophyl axis 81,82 and vaginal chlorhexidine. 83 We included both inborn and outborn babies but all studies had to include contact with a hospital that could undertake laboratory investigations for common bacterial pathogens such as group B streptococcus. These studies are biased towards patients with severe disease, 84,85 and more babies with group B streptococcal infection could have been included in these studies than those in the total population, thereby infl ating our incidence estimate.…”

Section: Discussionmentioning

confidence: 99%

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Edmond¹,

Kortsalioudaki²,

Scott³

et al. 2012

The Lancet

533

457

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SummaryBackground Despite widespread use of intrapartum antibiotic prophylaxis, group B streptococcus remains a leading cause of morbidity and mortality in infants in Europe, the Americas, and Australia. However, estimates of disease burden in many countries outside of these regions is not available. We aimed to examine the current global burden of invasive disease and the serotype distribution of group B streptococcus isolates.

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Section: Discussionmentioning

confidence: 99%

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Edmond¹,

Kortsalioudaki²,

Scott³

et al. 2012

The Lancet

533

457

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“…Stray-Pedersen et al demonstrated a significant decrease in both maternal and early neonatal infectious morbidity using vaginal douching with 120 ml of a solution of 0.2% chlorhexidine diacetate during childbirth [44]. However, in other studies in developed countries it has not been shown to significantly reduce life threatening infections in neonates and their mothers [45,46]. These different results may be influenced by methods of chlorhexidine application that were used.…”

Section: Current Prevention Strategies Used In European Countries Andmentioning

confidence: 99%

Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference

Renzo

Melin²,

Berardi

et al. 2014

The Journal of Maternal-Fetal & Neonatal Medicine

156

135

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Group B streptococcus (GBS) remains worldwide a leading cause of severe neonatal disease. Since the end of the 1990s, various strategies for prevention of the early onset neonatal disease have been implemented and have evolved. When a universal antenatal GBS screening-based strategy is used to identify women who are given an intrapartum antimicrobial prophylaxis, a substantial reduction of incidence up to 80% has been reported in the USA as in other countries including European countries. However recommendations are still a matter of debate due to challenges and controversies on how best to identify candidates for prophylaxis and to drawbacks of intrapartum administration of antibiotics. In Europe, some countries recommend either antenatal GBS screening or risk-based strategies, or any combination, and others do not have national or any other kind of guidelines for prevention of GBS perinatal disease. Furthermore, accurate population-based data of incidence of GBS neonatal disease are not available in some countries and hamper good effectiveness evaluation of prevention strategies. To facilitate a consensus towards European guidelines for the management of pregnant women in labor and during pregnancy for the prevention of GBS perinatal disease, a conference was organized in 2013 with a group of experts in neonatology, gynecologyobstetrics and clinical microbiology coming from European representative countries. The group reviewed available data, identified areas where results were suboptimal, where revised procedures and new technologies could improve current practices for prevention of perinatal GBS disease. The key decision issued after the conference is to recommend intrapartum antimicrobial prophylaxis based on a universal intrapartum GBS screening strategy using a rapid real time testing.

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“…Une revue de la littérature de la Cochrane en 2004 montrait une diminution significative du portage à SGB grâce à la désinfection vaginale par chlorhexidine mais sans diminution associée des IMF [9].…”

Section: Utilisation De La Chlorhexidineunclassified

Pour la pratique systématique du dépistage du streptocoque B dans le suivi de grossesse

Viala

Deruelle

2011

Gynécologie Obstétrique & Fertilité

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Vaginal chlorhexidine during labour to prevent early-onset neonatal group B streptococcal infection

Cited by 35 publications

References 35 publications

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Group B streptococcal disease in infants aged younger than 3 months: systematic review and meta-analysis

Intrapartum GBS screening and antibiotic prophylaxis: a European consensus conference

Pour la pratique systématique du dépistage du streptocoque B dans le suivi de grossesse

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