Vaginal Colonization and Antibiotic Susceptibility Pattern of Group B &amp;lt;i&amp;gt;Streptococcus&amp;lt;/i&amp;gt; Isolated from Pregnant Women in Maternit&amp;#233; de l’H&amp;#244;pital Des Soeurs de Pauvres de Bergame de Kimbanseke, Kinshasa, Democratic Republic of Congo

Iyamba, Jean-Marie Liesse; Mongane, Pascal Murhula; Lukukula, Cyprien Mbundu; Ngbandani, Benjamin Kodondi; Tshimpangila, Junior Disashi; Vihembo, Grégoire Mbusa; Kantola, Paul Tshilumbu; Wambale, José Mulwahaili; Kasongo, Jacques Onokodi; Kikuni, N. B. Takaisi

doi:10.4236/aim.2021.117026

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…Pregnancy-related diseases such as urinary tract infection, bacteremia, chorioamnionitis, postpartum endometritis, preterm labor, preterm rupture of membranes, and perinatal transfer of the organism are all possible outcomes of maternal GBS colonization. GBS's ability to rise from the lower genital tract and colonize the upper genital tract has been linked to intrauterine infection [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…In sub-Saharan Africa, the prevalence of Kampala in central Uganda was 3.9% prevalence of GBS [10] and Democratic Republic of Congo, women at 35 -37 weeks of gestation that were enrolled in the study, 24 (23.07%) were found to be GBS carriers [1]. In another study of sub-Saharan Africa Province, Sri Lanka GBS vaginal colonization in the 100 specimens was 18% (18 vaginal and 0 rectal) in another study 49% [11] (37 vaginal and 27 rectal) from Hospitals in Kenya were positive for GBS [12].…”

Section: Introductionmentioning

confidence: 99%

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Group B Streptococci Recto-Vaginal Colonization, Antimicrobial Susceptibility Pattern and Associated factors among Pregnant Women at Selected Health Facilities of Wolaita Sodo Town, Southern Ethiopia

Shano,

Takele,

Jejaw

et al. 2023

Preprint

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Background: Streptococcus agalactiae or Group B Streptococcal colonization of the gastrointestinal and genital tracts of pregnant women usually remains asymptomatic; even if it is the critical determinant of infection in neonates and young infants. It causes early and late onset of invasive Group B Streptococcus (GBS) disease manifesting as septicemia, meningitis and pneumonia. Now it is recognized as an important cause of maternal and neonatal morbidity and mortality in many parts of the world including Ethiopia where the magnitude of the problem has been little studied. The aim of this study was to assess the prevalence of GBS colonization, to identify associated risk factors and antimicrobial susceptibility pattern among pregnant women at selected health facilities of Wolaita Sodo Town, Southern Ethiopia. Methodology: A health facility based cross-sectional study design was conducted at WSUCSH & Wolaita Sodo Health Center from June to August, 2022. A total of 279 pregnant women who were in ANC follow up with at 35-37 weeks of gestation were included. For GBS isolation, recto-vaginal swabs were inoculated in 1ml Todd-Hewitt broth medium supplemented with 10μg/ml colistin and 15μg/ml nalidixic acid and followed by identification of isolates based on colonial morphology, gram stains, catalase reaction and CAMP tests. Antimicrobial susceptibility testing was performed using modified Kirby–Bauer disk diffusion method. All collected data were organized in Epi info 4.6.0.2, then transfer tabulated using SPSS version 20. Logistic regression analysis was used to see the association between variables. Finally, the p-value < 0.05 were considered statistically significant. Results: In present study, 279 pregnant mothers included and their age was between 15 to 38 years with a mean of 26.5 ± 4.5 years. Of all participants, the highest 120 (43.01%) were housewives. The overall carriage rate of GBS was 67(24.0%). GBS colonization showed a statistically significant association with college and above levels of maternal education [AOR= 6.610, 95% CI (1.724 - 25.349), P=0.01]. High susceptibility of GBS isolate was seen to Penicillin G & Chloramphenicol (92.5%) for each, Ampicillin, and Ceftriaxone (89.6%) each, following Vancomycin (74.62%), and Erythromycin (77%). Relatively, GBS showed high resistance to Tetracycline (88 %). Conclusion: In this study, the overall prevalence of GBS colonization was 24.0%. College and above educational level was statistically significant with GBS colonization. This study used to give attention to the management of pregnant women by making GBS culture one of the routine diagnoses during ANC follow-up and to prevent infection by early detection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Group B Streptococci Recto-Vaginal Colonization, Antimicrobial Susceptibility Pattern and Associated factors among Pregnant Women at Selected Health Facilities of Wolaita Sodo Town, Southern Ethiopia

Shano,

Takele,

Jejaw

et al. 2023

Preprint

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show abstract

“…Pregnancy-related diseases such as urinary tract infection, bacteremia, chorioamnionitis, postpartum endometritis, preterm labor, preterm rupture of membranes, and perinatal transfer of the organism are all possible outcomes of maternal GBS colonization. GBS’s ability to rise from the lower genital tract and colonize the upper genital tract has been linked to intrauterine infection ( Lämmler et al, 1995 ; Mengist et al, 2016 , 2017 ; Liesse Iyamba et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Evidence on maternal colonization prevalence remains sparse in African settings ( Gizachew et al, 2019 ). In sub-Saharan Africa, the prevalence of GBS in Kampala, central Uganda was 3.9% ( Tumuhamye et al, 2021 ), in the Democratic Republic of Congo, 23.07% ( Liesse Iyamba et al, 2021 ), and in Kenya 20.5% ( Jisuvei et al, 2020 ). In Sri Lanka, GBS vaginal colonization was 18% ( Dilrukshi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Group B Streptococci recto-vaginal colonization, antimicrobial susceptibility pattern, and associated factors among pregnant women at selected health facilities of Wolaita Sodo Town, Southern Ethiopia

Kumalo,

Gebre,

Shiferaw

et al. 2023

Front. Microbiol.

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BackgroundStreptococcus agalactiae or Group B Streptococcal colonization of the gastrointestinal and genital tracts of pregnant women usually remains asymptomatic, even though it is the critical determinant of infection in neonates and young infants. It causes early and late onset of invasive Group B Streptococcus (GBS) disease manifesting as septicemia, meningitis, and pneumonia. Now it is recognized as an important cause of maternal and neonatal morbidity and mortality in many parts of the world including Ethiopia, where the magnitude of the problem has been little studied. The aim of this study was to assess the prevalence of GBS colonization and to identify associated risk factors and antimicrobial susceptibility patterns among pregnant women at selected health facilities of Wolaita Sodo Town, Southern Ethiopia.MethodologyA health-facility-based cross-sectional study design was conducted at WSUCSH & Wolaita Sodo Health Center from June to August, 2022. A total of 279 pregnant women who were in ANC follow-up at 35–37 weeks of gestation were included. For GBS isolation, recto-vaginal swabs were inoculated in 1 mL Todd-Hewitt broth medium supplemented with 10 μg/mL colistin and 15 μg/mL nalidixic acid, followed by identification of isolates based on colonial morphology, gram stains, catalase reaction, and CAMP tests. Antimicrobial susceptibility testing was performed using a modified Kirby–Bauer disc diffusion method. All collected data were entered in Epi info 4.6.0.2, then transferred and tabulated using SPSS version 20. Logistic regression analysis was used to see the association between variables. Finally, a p-value <0.05 was considered statistically significant.ResultsIn the present study, 279 pregnant mothers, aged between 15 to 38 years with a mean of 26.5 ± 4.5 years, were included. Of all participants, the highest proportion (120) (43.01%) were housewives. The overall carriage rate of GBS was 67 (24.0%). GBS colonization showed a statistically significant association with college and above levels of maternal education [AOR = 6.610, 95% CI (1.724–25.349), p = 0.01]. High susceptibility of GBS isolate was seen with Penicillin G & Chloramphenicol (92.5%), Ampicillin, Ceftriaxone (89.6%), Vancomycin (74.62%), and Erythromycin (77%). Relatively, GBS showed high resistance to Tetracycline (88%).Conclusion and recommendationIn this study, the overall prevalence of GBS colonization was 24.0%. College and above educational level was statistically significant with GBS colonization. This study aimed to draw attention to the management of Group B Streptococci in pregnant women by making GBS culture one of the routine diagnoses during ANC follow-up and to prevent infection with early detection.

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Analytical performances of a point-of-care loop-mediated isothermal amplification assay to detect Group B Streptococcus in intrapartum pregnant women living in the Democratic Republic of the Congo

Tonen-Wolyec,

Otuli,

Otsatre-Okuti

et al. 2024

International Journal of Infectious Diseases

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Vaginal Colonization and Antibiotic Susceptibility Pattern of Group B <i>Streptococcus</i> Isolated from Pregnant Women in Maternité de l’Hôpital Des Soeurs de Pauvres de Bergame de Kimbanseke, Kinshasa, Democratic Republic of Congo

Cited by 5 publications

References 27 publications

Group B Streptococci Recto-Vaginal Colonization, Antimicrobial Susceptibility Pattern and Associated factors among Pregnant Women at Selected Health Facilities of Wolaita Sodo Town, Southern Ethiopia

Group B Streptococci Recto-Vaginal Colonization, Antimicrobial Susceptibility Pattern and Associated factors among Pregnant Women at Selected Health Facilities of Wolaita Sodo Town, Southern Ethiopia

Group B Streptococci recto-vaginal colonization, antimicrobial susceptibility pattern, and associated factors among pregnant women at selected health facilities of Wolaita Sodo Town, Southern Ethiopia

Analytical performances of a point-of-care loop-mediated isothermal amplification assay to detect Group B Streptococcus in intrapartum pregnant women living in the Democratic Republic of the Congo

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