Vaginal cuff dehiscence: report of two cases

Vardar, Baran Umut; Midkiff, Brian

doi:10.1016/j.radcr.2021.05.038

Cited by 4 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…VCD is a clinical diagnosis. Surgeons should have a high index of suspicion when patients present with the following symptoms: pelvic or abdominal pain, vaginal bleeding, vaginal pressure, increased vaginal discharge, and/or gush of fluid as these are the most common presenting symptoms [1,4,7,11,37]. Thorough history taking and pelvic examination including speculum are vital to evaluate for VCD/VCDE [11].…”

Section: Diagnosismentioning

confidence: 99%

“…Though there is no consensus on the most optimal route of repair, minimally invasive approaches (vaginal, laparoscopic, or combination) have become the predominant method of management in recent literature, with laparotomy reserved for patients with hemodynamic instability or necrotic bowel [1,2,11,37,38,[41][42][43][44][45].…”

Section: Managementmentioning

confidence: 99%

“…The bladder and rectum may require further dissection to allow at least 1 cm of full-thickness bite during closure [4,5]. Similar to the management of initial cuff closure, there is no one recommended way to close the cuff after a dehiscence has occurred [1,2,[39][40][41]. Some authors favor monofilament sutures for the theoretical advantage of reducing infection [42,48,49].…”

Section: Managementmentioning

confidence: 99%

“…The most common reason for VCD is postoperative resumption of penetrative vaginal intercourse [1,4,7,17 ▪ ]. There are no exact recommendations of when patients should be cleared to resume intercourse; commonly patients are instructed on complete pelvic rest for 6–12 weeks postoperatively depending on surgeon preference and patient risk factors [3 ▪▪ ,4].…”

Section: Risk Factorsmentioning

confidence: 99%

“…VCD with evisceration (VCDE) is the protrusion of intraperitoneal contents through the cuff defect. VCDE is a surgical emergency and, if left untreated, can result in bowel injury, ischemia/necrosis, peritonitis, sepsis, and death [1,2,3 ▪▪ ,4,5].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Prevention and management of vaginal cuff dehiscence: an updated review

Pinho

Liu

Kim

et al. 2022

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

Purpose of reviewMinimally invasive hysterectomy has gained popularity because of its many benefits. However, laparoscopic and robotic assisted hysterectomy have been associated with increased risk of vaginal cuff dehiscence. This review is meant to address risk management and prevention of vaginal cuff dehiscence in patients undergoing minimally invasive hysterectomy. Recent findingsRecent findings in the literature focus on addressing modifiable risk factors in patients and on using good surgical technique to help minimize the risk of vaginal cuff dehiscence.

show abstract

Section: Diagnosismentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Section: Managementmentioning

confidence: 99%

Section: Risk Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevention and management of vaginal cuff dehiscence: an updated review

Pinho

Liu

Kim

et al. 2022

Current Opinion in Obstetrics &Amp; Gynecology

View full text Add to dashboard Cite

show abstract

Empowering High Throughput Screening of 3D Models: Automated Dispensing of Cervical and Endometrial Cancer Cells

Seymour,

Cadena,

Johnson

et al. 2024

Preprint

View full text Add to dashboard Cite

Purpose: Cervical and endometrial cancers pose significant challenges in women's healthcare due to their high mortality rates and limited treatment options. High throughput screening (HTS) of cervical and endometrial cancer in vitro models offer a promising avenue for drug repurposing and broadening patient treatment options. Traditional two-dimensional (2D) cell-based screenings have limited capabilities to capture crucial multicellular interactions, that are improved upon in three dimensional (3D) multicellular tissue engineered models. However, manual fabrication of the 3D platforms is both time consuming and subject to variability. Thus, the goal of this study was to utilize automated cell dispensing to fabricate 3D cell-based HTS platforms using the HP D100 Single Cell Dispenser to dispense cervical and endometrial cancer cells. Methods: We evaluated the effects of automated dispensing of the cancer cell lines by tuning the dispensing protocol to align with cell size measured in solution and the minimum cell number for acceptable cell viability and proliferation. We modified our previously reported coculture models of cervical and endometrial cancer to be in a 384 well plate format and measured microvessel length and cancer cell invasion. Results: Automatically and manually dispensed cells were directly compared revealing minimal differences between the dispensing methods. These findings suggest that automated dispensing of cancer cells minimally affects cell behavior and can be deployed to decrease in vitro model fabrication time. Conclusions: By streamlining the manufacturing process, automated dispensing holds promise for enhancing efficiency and scalability of 3D in vitro HTS platforms, ultimately contributing to advancement in cancer research and treatment.

show abstract