Vaginal flora in preterm premature rupture of membranes and their sensitivity to commonly used antibiotics

Rani, Shikha; Mehra, Reeti; Gupta, Varsha; Huria, Anju; Chander, Jagdish

doi:10.3126/ajms.v5i4.9889

Cited by 14 publications

(15 citation statements)

References 8 publications

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“…Furthermore, the results showed no significant difference in the number of A. baumannii colonizers between women with PPROM and those with NLT. In comparison to a report by Rani et al (2014), where Acinetobacter colonizers constituted 2% of their PPROM cases, we found higher percentage (7.4%) of positivity for A. baumannii in our study. The percentage of A. baumannii-positive in their PPROM cases could even be lower than 2% because the species of Acinetobacter isolated their study were not identified.…”

Section: Discussioncontrasting

confidence: 90%

Colonization of Acinetobacter baumannii, Streptococcus agalactiae (GBS) and Candida albicans in preterm premature rupture of membrane (PPROM) compared to normal labor at term

Mohd-Zain¹,

Yahcob²,

Sood³

et al. 2019

MJM

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Aims: Preterm premature rupture of membrane (PPROM) is usually associated with maternal vaginal colonization of Group B Streptococci (GBS). However, there are reports on isolation of Acinetobacter baumannii in PPROM cases. In order to ascertain A. baumannii's role in PPROM, we determine the colonization of A. baumannii and other common vaginal tract flora, i.e. GBS and Candida albicans, in women with PPROM, and compared them to those with normal labor at term (NLT). The transmissibility of the organisms to their babies was also investigated. Methodology and results: A total of 218 high vaginal swabs from 108 and 100 women with PPROM and NLT respectively were collected. The transmission of these organisms to their 215 babies was determined by swabbing the ears and axillae. These were cultured for isolation of A. baumannii, GBS and C. albicans. Results showed that mothers with PPROM were predominantly colonized with GBS (32.4%), followed by C. albicans (19.4%) and A. baumannii (7.4%), compared to 10.9%, 17.3% and 7.2% respectively, in women with NLT. Between 34 to 50% of the babies of mothers with PPROM acquired the organisms, with GBS being the most significantly (p=0.000) transferred compared to other organisms. Coexistence of A. baumannii with either GBS or C. albicans, or both, did not enhance the occurrence of PPROM. Conclusion, significance and impact of study: Colonization of A. baumannii in vaginal tract of pregnant women does not increase the possibility of PPROM, as compared to GBS.

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Section: Discussioncontrasting

confidence: 90%

Colonization of Acinetobacter baumannii, Streptococcus agalactiae (GBS) and Candida albicans in preterm premature rupture of membrane (PPROM) compared to normal labor at term

Mohd-Zain¹,

Yahcob²,

Sood³

et al. 2019

MJM

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“…In a cross-sectional study, E. coli was the most common isolated bacteria from lower genital tract culture followed by Staphylococcus aureus and Candida species. [38] The result of the current study supported the previous research in that the bacteria E. coli is the most isolated bacteria from the high vaginal swab.…”

Section: Discussionsupporting

confidence: 89%

Evaluation of maternal and neonatal outcomes in the case of preterm premature rupture of membranes and their relationship to prenatal maternal indicators: Across -sectional descriptive study

El-Kashif

Fathy²,

Elsaba³

2020

JNEP

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Background and aim: Preterm premature rupture of membranes is one of the most important causes of pregnancy complication and a significant role in the occurrence of perinatal morbidity and mortality. The present study aims to evaluate the maternal and neonatal outcomes in the case of preterm premature rupture of membranes and their relationship to prenatal maternal indicators. Subjects and methods: A cross-sectional descriptive design was used to evaluate 68 pregnant women with a gestational age of 32 to before 37 weeks, and singleton pregnancy complicated by preterm premature rupture of membranes who fulfilled the inclusion criteria. The data were collected by convenience sampling using standardized tools. Results: A linear correlation was used to show a correlation between maternal clinical indicators with the predictive maternal and neonatal outcome using a Spearman Rho correlation coefficient. The most significant neonatal outcomes are neonatal intensive care unit admission, neonatal respiratory distress syndrome, and early neonatal sepsis. More than two-thirds of the studied women had expectant management, and less than one-fourth of them have postnatal sepsis. Conclusion and recommendation: The prenatal maternal indicators are the significant values for maternal and neonatal outcome in case of preterm premature rupture of membranes, so A further larger prospective study is recommended to demonstrate the difference in incidence, management protocol of preterm premature rupture of the membranes in the delivery and maternity health care services.

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“…coli carriers suggests that vaginal E . coli colonization is a risk factor for pPROM and preterm birth [ 20 , 21 ] as well as the starting point for progression to severe infection [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Vaginal versus Obstetric Infection Escherichia coli Isolates among Pregnant Women: Antimicrobial Resistance and Genetic Virulence Profile

et al. 2016

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Vaginal Escherichia coli colonization is related to obstetric infections and the consequent development of infections in newborns. Ampicillin resistance among E. coli strains is increasing, which is the main choice for treating empirically many obstetric and neonatal infections. Vaginal E. coli strains are very similar to extraintestinal pathogenic E. coli with regards to the virulence factors and the belonging to phylogroup B2. We studied the antimicrobial resistance and the genetic virulence profile of 82 E. coli isolates from 638 vaginal samples and 63 isolated from endometrial aspirate, placental and amniotic fluid samples from pregnant women with obstetric infections. The prevalence of E. coli in the vaginal samples was 13%, which was significant among women with associated risk factors during pregnancy, especially premature preterm rupture of membranes (p<0.0001). Sixty-five percent of the strains were ampicillin-resistant. The E. coli isolates causing obstetric infections showed higher resistance levels than vaginal isolates, particularly for gentamicin (p = 0.001). The most prevalent virulence factor genes were those related to the iron uptake systems revealing clear targets for interventions. More than 50% of the isolates belonged to the virulent B2 group possessing the highest number of virulence factor genes. The ampicillin-resistant isolates had high number of virulence factors primarily related to pathogenicity islands, and the remarkable gentamicin resistance in E. coli isolates from women presenting obstetric infections, the choice of the most appropriate empiric treatment and clinical management of pregnant women and neonates should be carefully made. Taking into account host-susceptibility, the heterogeneity of E. coli due to evolution over time and the geographical area, characterization of E. coli isolates colonizing the vagina and causing obstetric infections in different regions may help to develop interventions and avoid the aetiological link between maternal carriage and obstetric and subsequent puerperal infections.

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Vaginal flora in preterm premature rupture of membranes and their sensitivity to commonly used antibiotics

Cited by 14 publications

References 8 publications

Colonization of Acinetobacter baumannii, Streptococcus agalactiae (GBS) and Candida albicans in preterm premature rupture of membrane (PPROM) compared to normal labor at term

Colonization of Acinetobacter baumannii, Streptococcus agalactiae (GBS) and Candida albicans in preterm premature rupture of membrane (PPROM) compared to normal labor at term

Evaluation of maternal and neonatal outcomes in the case of preterm premature rupture of membranes and their relationship to prenatal maternal indicators: Across -sectional descriptive study

Vaginal versus Obstetric Infection Escherichia coli Isolates among Pregnant Women: Antimicrobial Resistance and Genetic Virulence Profile

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