Vaginal Laser Doppler Flowmetry Pre- and Posthysterectomy

Richman, Susan; Sarrel, Philip M.

doi:10.1080/00926230490247129

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…Another study in rabbits used the same technology to show that clitoral and vaginal flow decreased in lower estrogen states (54). Laser Doppler flowmetry has also been used to assess vaginal blood flow in eight healthy women undergoing benign hysterectomy (55). No significant differences were found in blood flow before and after the procedure.…”

Section: Resultsmentioning

confidence: 99%

Physiologic measures of sexual function in women: a review

Woodard

Diamond

2009

Fertility and Sterility

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Results-Many unique physiologic methods of evaluating female sexual function have been developed over the last four decades. Each method has its benefits and limitations.Conclusions-Many physiologic methods exist, but most are not well-validated. Additionally, there has been an inability to correlate most physiologic measures with subjective measures of sexual arousal. Furthermore, given the complex nature of the sexual response in women, physiologic measures should be considered in context of other data, including the history, physical exam, and validated questionnaires. Nonetheless, the existence of appropriate physiologic measures is vital to our understanding of female sexual function and dysfunction.

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Section: Resultsmentioning

confidence: 99%

Physiologic measures of sexual function in women: a review

Woodard

Diamond

2009

Fertility and Sterility

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“…Laser Doppler flowmetry (LDF) has been used in animal-and human-based research to study genital blood flow in different contexts [6][7][8][9][10]. For instance, it is possible to detect changes in rabbit and dog clitoral blood from pelvic nerve stimulation [11,12].…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Cavernous Nerve Stimulation and Laser-Doppler Flowmetry During Radical Prostatectomy

Axelson

Johansson

Bill‐Axelson

2013

The Journal of Sexual Medicine

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Introduction Erectile dysfunction is a common side effect following radical prostatectomy mainly due to damage of the pelvic autonomic nerve fibers (cavernous nerves). Intraoperative electrical stimulation of the cavernous nerves while measuring changes in penile girth has previously been shown to provide the surgeon with feedback of nerve integrity. Aim To test the feasibility of recording changes in glans penis blood flow by Laser Doppler flowmetry from cavernous nerve stimulation. Methods Fifteen patients with localized prostate cancer undergoing radical prostatectomy had electrical stimulation of the proximal and distal parts of the neurovascular bundles after prostate removal. The stimulation consisted of 30–40 seconds biphasic constant current (10–30 mA) with 0.5 millisecond pulse duration. Main Outcome Measures Stimulus induced changes in penile blood flow was recorded from a Laser Doppler probe attached to the glans penis. Changes in penile girth were simultaneously recorded from a mercury-in rubber strain gauge. Erectile function was evaluated three months after surgery. Results Ten patients had stimulus induced increase in Laser Doppler flow unilaterally (N = 7) or bilaterally (N = 3). Out of 10 patients, 6 reported some preserved erectile function postoperatively at 3 months follow-up (indicating 6 true and 4 false positives). Three patients had no Doppler response from stimulation and had no postoperative erectile function postoperatively (indicating three true negatives). Two patients were excluded from the study due to bad signal quality in the Laser Doppler signal. In the majority of patients, stimulation produced increase in penile girth sensed by the strain gauge. Conclusion This preliminary report provides evidence that Laser Doppler Flowmetry is able to detect increased penile blood flow from intraoperative electrical stimulation of the neurovascular bundles. However, further improvement in the recording technique is required. Laser Doppler Flowmetry may also be feasible to confirm autonomic nerve sparing in women undergoing pelvic surgery.

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Changes of Apomorphine-Induced Vaginal Hemodynamics in an Ovariectomized Rat Model Using Near-Infrared Spectroscopic Probe

Jeong

Lee

Seong

et al. 2021

The Journal of Sexual Medicine

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INTRODUCTION Female sexual arousal disorder (FSAD) can be caused by the change in vaginal structure due to the decline of estrogen and one of the main symptoms is vaginal dryness. FSAD is a prevalent problem afflicting women all over the world and thus the interest is growing on the matter, but related studies of monitoring FSAD using a non-invasive optical method barely have been carried out. Aim This study aims to investigate the longitudinal changes in female sexual arousal response induced by apomorphine (APO) administration in the ovariectomized rat using near-infrared spectroscopy (NIRS) probe. Methods To elicit sexual arousal, APO was administered subcutaneously to animals (n = 6) before and after ovariectomy, and the changes in oxyhemoglobin (OHb), deoxyhemoglobin (RHb), total hemoglobin (THb) concentration, and temperature on the vaginal wall after APO administration were monitored bi-weekly for 8 weeks. Furthermore, estradiol hormone, vaginal secretion, and body weight have been measured for comparison with the results from vaginal hemodynamics. RESULTS APO administration caused the increase of vaginal OHb and RHb concentration but a decrease in temperature. The amplitude of OHb, RHb, and THb increase induced by APO gradually decreased over 8 weeks after ovariectomy while the decrease in vaginal temperature became profound. The level of estradiol and vaginal secretions also decreased over 8 weeks after ovariectomy, but bodyweight showed an increasing trend. CONCLUSIONS A comparison between the parameters measured from the NIRS probe and the others (estradiol level, amount of vaginal secretion, and body weight) proved that the NIRS has the potential as a monitoring tool to evaluate female sexual arousal response.

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Vaginal Laser Doppler Flowmetry Pre- and Posthysterectomy

Cited by 8 publications

References 10 publications

Physiologic measures of sexual function in women: a review

Physiologic measures of sexual function in women: a review

Intraoperative Cavernous Nerve Stimulation and Laser-Doppler Flowmetry During Radical Prostatectomy

Changes of Apomorphine-Induced Vaginal Hemodynamics in an Ovariectomized Rat Model Using Near-Infrared Spectroscopic Probe

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