Vaginal misoprostol as medical treatment for first trimester spontaneous miscarriage

Abstract

We recommend repeated vaginal misoprostol 400 microg given on days 1, 3 and 5 as a treatment option for women with first trimester spontaneous miscarriage.

Misoprostol treatment vs expectant management in women with early non‐viable pregnancy and vaginal bleeding: a pragmatic randomized controlled trial

“…In addition, in many trials, D&E was carried out after a very short period of observation, so that the chance of successful treatment with long observation cannot be evaluated properly. Results of published randomized trials comparing misoprostol treatment with expectant management or placebo are summarized in Table 4 18,19,23,25,[27][28][29][30][31] .…”

“…D&E before first follow-up (n = 2) (Bleeding (n = 2)) D&E before first follow-up (n = Follow-up day 24 (22)(23)(24)(25)(26)(27)(28) (n = 34) Failed to appear (n = 2) Follow-up day 31 (30)(31)(32)(33)(34)(35)(36)(37) (n = 11)…”

The medical management of missed miscarriage: outcomes from a prospective, single‐centre, Australian cohort

“…5,9,10,12,14,19,20,[25][26][27][28][29][30][31][32][33][34][35][36][37][38]41 (Table 1) The success rate reported in trials is closely related to the length of time after treatment at which the uterus is reassessed by ultrasound exam. 16 Early studies on the use misoprostol for incomplete abortion tested a range of doses (400 mcg to 1200 mcg) and routes (oral, vaginal, intrauterine, etc.…”

Sublingual versus vaginal misoprostol for medical termination of pregnancy: a comparative study

“…4 Vacuum aspiration is the conventional method of evacuation of uterus and is associated with 4-10% of complications like bleeding, infection, uterine perforation and decreased fertility. 5 number of approved facilities over the years from 1,877 in 1976 to 9,859 in 2002 to 12,510 in 2010 access to safe abortion remains inadequate, especially in rural areas. 7,8 Provisional government figures estimate that 621,748 abortions were performed in 2011-2012, and the number increased slightly to 636,306 in 2012-2013, indicating an annual rate of about two abortions per 1,000 women aged 15-49 in 2013.…”