Vaginal Mucoadhesive Drug Delivery System

Abstract

Mucoadhesive drug delivery systems are delivery systems which utilize the property of bioadhesion of certain polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time. Many of these delivery routes, particularly those through the nasal, ocular, reproductive and gastrointestinal system, involve contact with mucosal surfaces. The gastrointestinal route has been particularly popular among medical staff and patients alike. Although convenient, unfortunately, this route can be very inefficient for a number of reasons, including too rapid transit of the drug-containing delivery system past the optimum site for absorption, which is normally the small intestine and to a lesser degree the stomach and colon. Mucoadhesive formulations use polymers as the adhesive component. Mucoadhesive drug delivery systems are available in the form of tablets, films, patches, and gels for oral, buccal, nasal, ocular, vaginal, rectal and topical routes for both systemic and local effects. This review article represents the various aspects of vaginal drug delivery system, bioadhesion mechanism, Theory of bioadhesion, factors affecting bioadhesion, various types of vaginal formulation etc.

Design and Development of Sertaconazole Nitrate Loaded Silver Nanoparticulate Mucoadhesive Tablets for the Treatment of Vaginal Candidiasis

“…The Monsanto hardness tester was used to determine the hardness of tablets [27]. The ten tablets from each batch were selected randomly and the value was reported in terms of kg/cm 2 [26] [32]. The friability of tablets was determined using Roche friabilator as per USP.…”

“…But in combination with HPMC K15M swelling index reduced and remained intact. While the increase in HPMC K15M concentration caused a greater degree of the swelling index, HPMC K15M facilitates the formation of a protective viscous gel layer preceding section of water into the lattice ruining quick hydration of the tablet inward core due to its high viscosity and was able to maintain the integrity of the tablet [32,49]. As a result matrix integrity, swelling process, as well as mucoadhesive properties, were all significantly influenced by the polymer's viscosity [47].…”