Vaginal progesterone as luteal phase support in an IVF/GIFT programme

Polson, D. W.; Rogers, Peter A W; Krapez, J.; Leeton, John

doi:10.1016/0028-2243(92)90276-5

Cited by 21 publications

(5 citation statements)

References 12 publications

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“…P 4 absorbed locally is expected to support the luteal phase and thus intensify endometrial decidualization. However, a randomized controlled study of pregnancy rates following IVF indicated no significant difference in pregnancy rates following the administration of P 4 pessaries (Polson et al 1992). Consequently, there is an urgent need for improved decidualizing agents in assisted reproduction.…”

Section: Discussionmentioning

confidence: 99%

Seminal plasma enhances and accelerates progesterone-induced decidualisation of human endometrial stromal cells

Doyle

Sampson

Zenzmaier

et al. 2012

Reprod. Fertil. Dev.

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In preparation for embryo implantation, endometrial stromal cells (ESC) undergo differentiation, termed decidualisation. Enhancing endometrial decidualisation may overcome reduced endometrial receptivity, a major limiting factor in natural and assisted reproduction. To determine whether seminal plasma (SP) influences decidualisation, primary human ESC were treated with progesterone (P4, 50 ng mL(-1)) in the presence or absence of dialysed SP (0.5%) for 24 h or for up to 27 days to investigate immediate early effects or the effects of prolonged exposure, respectively. Combined SP and P4 treatment induced ESC morphological differentiation. Relative to control, P4 alone, and SP alone combined treatment with SP and P4 for 27 days significantly upregulated mRNA levels of the decidua-specific markers prolactin (PRL) and insulin-like growth factor binding protein 1 (IGFBP1). Consistently, PRL protein secretion was significantly increased over the course of 27 days combined SP and P4 treatment relative to control, P4 alone and SP alone. Likewise, IGFBP1 secretion was significantly greater relative to control and P4 alone over the course of 27 days. Thus, SP enhances and accelerates P4-mediated decidualisation of human ESC and may enhance endometrial receptivity.

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Section: Discussionmentioning

confidence: 99%

Seminal plasma enhances and accelerates progesterone-induced decidualisation of human endometrial stromal cells

Doyle

Sampson

Zenzmaier

et al. 2012

Reprod. Fertil. Dev.

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“…Moreover, whilst there is global agreement that luteal support is essential, there is no consensus on the optimum duration of luteal support. Importantly, some studies have recently suggested that luteal support can be safely withdrawn at the time of biochemical pregnancy confi rmation, (Mochtar et al, 1996;Schmidt et al, 2001;Nyboe Andersen et al, 2002) while others have recommended withdrawal at 5 weeks gestation (Kohls et al, 2012), at fi rst ultrasound (Aboulghar et al, 2008), up to 8 weeks gestation (Polson et al, 1992;Miles et al, 1994) or up to 12 weeks gestation (Smitz et al, , 1992Van Steirteghem et al, 1988;Ludwig & Diedrich, 2001).…”

Section: Introductionmentioning

confidence: 97%

Duration of luteal support after IVF is important, so why is there no consistency in practice? The results of a dynamic survey of practice in the United Kingdom

Russell¹,

Kingsland²,

Alfirević³

et al. 2014

Human Fertility

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Luteal support is considered as an essential component of IVF treatment following ovarian stimulation and embryo transfer. Several studies have consistently demonstrated a benefit of luteal support compared with no treatment and whilst a number of preparations are available, no product has been demonstrated as superior. There is an emerging body of evidence which suggests that extension of luteal support beyond biochemical pregnancy does not confer a benefit in terms of successful pregnancy outcome. We performed two surveys separated by 5 years of practice evolution, with the latter reporting on the use of luteal support in all IVF clinics in the UK. All clinics reported utilising luteal support with the majority favouring the use of Cyclogest 400 mg twice daily. In contrast, there was no consensus on the optimal duration of luteal support. Whilst 24% of clinics withdrew luteal support at biochemical confirmation of pregnancy, 40% continued treatment until 12 weeks gestation. Several clinics even extended luteal support beyond 12 weeks gestation. We observed no difference in practice based on the size of the IVF unit or treatment funding source. Although there was some change in practice between surveys in many clinics, there was no uniformity in the direction of change.

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“…Progesterone (P) supplementation is suspended around positive b-hCG (5,6) or extended up to 8 weeks (7,8) or 12 weeks of pregnancy (2,(9)(10)(11)(12)(13). Because the luteal-placental shift happens around week 7-8, traditionally LPS has been maintained until then, with the added benefit that exogenous P has seemed to be a risk-free drug.…”

mentioning

confidence: 98%

Early progesterone cessation after in vitro fertilization/intracytoplasmic sperm injection: a randomized, controlled trial

Kohls

Ruiz

Martínez

et al. 2012

Fertility and Sterility

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Vaginal progesterone as luteal phase support in an IVF/GIFT programme

Cited by 21 publications

References 12 publications

Seminal plasma enhances and accelerates progesterone-induced decidualisation of human endometrial stromal cells

Seminal plasma enhances and accelerates progesterone-induced decidualisation of human endometrial stromal cells

Duration of luteal support after IVF is important, so why is there no consistency in practice? The results of a dynamic survey of practice in the United Kingdom

Early progesterone cessation after in vitro fertilization/intracytoplasmic sperm injection: a randomized, controlled trial

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