Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term

Thomas, James; Fairclough, Anna; Kavanagh, Jennifer; Kelly, Anthony

doi:10.1002/14651858.cd003101.pub3

Cited by 179 publications

(117 citation statements)

References 126 publications

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“…The beneficial effects of delivery of the inhibitor of the PGE2-degrading enzyme (15-PGDH) SW033291 on hematopoietic, liver, and colon regeneration are likely due to a similar augmentation of endogenous PGE2 levels (45). Notably, PGE2 and its analogs have safely been used in patients for more than a decade, for instance to induce labor (46) and to promote hematopoietic stem-cell transplantation (44). Together with our findings, these studies pave the way for its clinical use in boosting muscle repair after injury.…”

Section: Discussionmentioning

confidence: 99%

Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength

Palla

Blake

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

184

169

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This contribution is part of the special series of Inaugural Articles by members of the National Academy of Sciences elected in 2016.Contributed by Helen M. Blau, May 15, 2017 (sent for review April 3, 2017; reviewed by Douglas P. Millay and Fabio M. V. Rossi)Skeletal muscles harbor quiescent muscle-specific stem cells (MuSCs) capable of tissue regeneration throughout life. Muscle injury precipitates a complex inflammatory response in which a multiplicity of cell types, cytokines, and growth factors participate. Here we show that Prostaglandin E2 (PGE2) is an inflammatory cytokine that directly targets MuSCs via the EP4 receptor, leading to MuSC expansion. An acute treatment with PGE2 suffices to robustly augment muscle regeneration by either endogenous or transplanted MuSCs. Loss of PGE2 signaling by specific genetic ablation of the EP4 receptor in MuSCs impairs regeneration, leading to decreased muscle force. Inhibition of PGE2 production through nonsteroidal anti-inflammatory drug (NSAID) administration just after injury similarly hinders regeneration and compromises muscle strength. Mechanistically, the PGE2 EP4 interaction causes MuSC expansion by triggering a cAMP/phosphoCREB pathway that activates the proliferation-inducing transcription factor, Nurr1. Our findings reveal that loss of PGE2 signaling to MuSCs during recovery from injury impedes muscle repair and strength. Through such gain-or loss-of-function experiments, we found that PGE2 signaling acts as a rheostat for muscle stem-cell function. Decreased PGE2 signaling due to NSAIDs or increased PGE2 due to exogenous delivery dictates MuSC function, which determines the outcome of regeneration. The markedly enhanced and accelerated repair of damaged muscles following intramuscular delivery of PGE2 suggests a previously unrecognized indication for this therapeutic agent. muscle stem cells | PGE2 | regeneration | NSAIDs | strength

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Section: Discussionmentioning

confidence: 99%

Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength

Palla

Blake

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

184

169

View full text Add to dashboard Cite

show abstract

“…A meta-analysis has shown that the vaginal delivery of prostaglandins is the most effective method in labor pre-induction compared to other routes of administration [57]. When choosing prostaglandin for labor pre-induction, one should remember that these two molecules differ significantly in terms of pharmacokinetics: misoprostol has a much stronger uterotonic effect than dinoprostone and is therefore more effective in less mature cervix, e.g.…”

Section: The Use Of Prostaglandins For Labor Pre-inductionmentioning

confidence: 99%

Polish Gynecological Society Recommendations for Labor Induction

Bomba‐Opoń¹,

Drews²,

Huras³

et al. 2017

Ginekol Pol

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“…Nonetheless, mechanical methods compared to prostaglandins were found to have a decreased chance of hyper stimulation and fetal heart rate modulation [4,23] . In a review from 2011 mechanical agents were found to be more successful in women with an unfavorable cervix compared to the usage of Oxytocin alone [24,25] .…”

Section: Comparison To Pharmacological Agentsmentioning

confidence: 99%

Cervical ripening with an osmotic dilator (Dilapan-S) in term pregnancies – An observational study

Maier¹

2015

JGNB

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Objective: The procedure of labor induction becomes increasingly important as the number of pregnancies requiring induction rises in the Western countries due to multiple reasons. In addition, a growing number of patients is aiming to achieve vaginal birth after cesarean section (VBAC). No pharmacological agent is licensed in this group of patients. A newly developed hydrophilic agent (Dilapan-S) is now available for cervical ripening, and is indicated also for patients with a previous cesarean section. Methods: Observational, non-interventional study in a tertiary perinatal center in Berlin, Germany in 2014. Eighty-three women at term with a singleton pregnancy and cephalic presentation were included. Results: In total, 60.2% of patients delivered vaginally, 4.8% by ventouse/forceps and 34.9% by secondary cesarean section. Parous women were found to have a significantly higher chance of vaginal birth (82.6% vs. 60.2% in total, p = 0.019). Patient's ≥ 35 years showed a tendency towards increased rates of ventouse and cesarean section (11.1% vs. 4.8% and 38.9% vs. 34.9% respectively). There was a tendency towards a higher rate of vaginal birth in patients with previous cesarean section (66.7% vs. 59.2%). No adverse fetal or maternal outcomes were noted. Conclusions:The application of Dilapan-S is cost-effective as patients can be seen in outpatient care. The device is efficient and safe. It is an attractive option for physicians and patients to lower the cesarean section rate by facilitating VBAC.

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Vaginal prostaglandin (PGE2 and PGF2a) for induction of labour at term

Abstract: Analysis 10.2. Comparison 10 (2.3) PGF2a vs placebo (women with an unfavourable cervix), Outcome 2 Uterine hyperstimulation with FHR changes..

Cited by 179 publications

References 126 publications

Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength

Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength

Polish Gynecological Society Recommendations for Labor Induction

Cervical ripening with an osmotic dilator (Dilapan-S) in term pregnancies – An observational study

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