Vaginal treatment with lactic acid gel delays relapses in recurrent urinary tract infections: results from an open, multicentre observational study

Diebold, Ruth; Schopf, Bettina; Stammer, Holger; Mendling, Werner

doi:10.1007/s00404-021-06040-8

Cited by 4 publications

(1 citation statement)

References 44 publications

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“…In addition, an acidic pH has a growth-inhibiting effect on many pathogens. Acidifying preparations, administered intravaginally, may be used in patients with recurrent BV after antibiotic therapy for six to ten days daily, or as “maintenance therapy” once or twice a week for a longer period of time [ 81 ].…”

Section: Substances With Lactic Acidmentioning

confidence: 99%

Vaginal Microbiome in Reproductive Medicine

et al. 2022

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The human microbiome has been given increasing importance in recent years. The establishment of sequencing-based technology has made it possible to identify a large number of bacterial species that were previously beyond the scope of culture-based technologies. Just as microbiome diagnostics has emerged as a major point of focus in science, reproductive medicine has developed into a subject of avid interest, particularly with regard to causal research and treatment options for implantation failure. Thus, the vaginal microbiome is discussed as a factor influencing infertility and a promising target for treatment options. The present review provides an overview of current research concerning the impact of the vaginal microbiome on the outcome of reproductive measures. A non-Lactobacillus-dominated microbiome was shown to be associated with dysbiosis, possibly even bacterial vaginosis. This imbalance has a negative impact on implantation rates in assisted reproductive technologies and may also be responsible for habitual abortions. Screening of the microbiome in conjunction with antibiotic and/or probiotic treatment appears to be one way of improving pregnancy outcomes.

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Section: Substances With Lactic Acidmentioning

confidence: 99%

Vaginal Microbiome in Reproductive Medicine

et al. 2022

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Definitions of Urinary Tract Infection in Current Research: A Systematic Review

Bilsen,

Jongeneel,

Schneeberger

et al. 2023

Open Forum Infectious Diseases

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Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic parameters are involved. In this systematic review we aimed to gain insight into how UTI is defined across current studies. We included 47 studies, published between January 2019 and May 2022, investigating therapeutic or prophylactic interventions in adult patients with UTI. Signs and symptoms, pyuria and a positive urine culture were required in 85%, 28% and 55% of study definitions, respectively. Five studies (11%) required all three categories for the diagnosis of UTI. Thresholds for significant bacteriuria varied from 103 to 105 colony-forming units/mL. None of the 12 studies including acute cystitis and 2/12 (17%) defining acute pyelonephritis used identical definitions. Complicated UTI was defined by both host factors and systemic involvement in 9/14 (64%) studies. In conclusion, UTI definitions are heterogeneous across recent studies, highlighting the need for a consensus-based, research reference standard for UTI.

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The use of a lactic acid gel in the treatment and prevention of bacterial vaginosis and urinary tract infections as a challenge to antibacterial therapy. A literature review

Minakova

Dzhibladze²,

Zuev³

et al. 2023

Journal of obstetrics and women's diseases

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Bacterial vaginosis and urinary tract infections are common conditions that lead to a decrease in the quality of life and significant economic costs. The review provides up-to-date information on the role of lactic acid in the microbiota of the vagina and urinary tract, as well as on the use of a lactic acid gel in these conditions. Bacterial vaginosis is associated with an increased risk of urinary tract infections. Antibacterial therapy demonstrates statistically significant results in treating exacerbation, but not preventing further relapses, which is due to the possible high ability of bacteria to form biofilms. Lactic acid, unlike hydrogen peroxide, is involved in maintaining the vaginal microbiota and enhancing its protective function against sexually transmitted infections, and indirectly affects the urinary microbiota. This may allow the use of lactic acid for the treatment and prevention of relapses in both bacterial vaginosis and urinary tract infections.

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Vaginal treatment with lactic acid gel delays relapses in recurrent urinary tract infections: results from an open, multicentre observational study

Cited by 4 publications

References 44 publications

Vaginal Microbiome in Reproductive Medicine

Vaginal Microbiome in Reproductive Medicine

Definitions of Urinary Tract Infection in Current Research: A Systematic Review

The use of a lactic acid gel in the treatment and prevention of bacterial vaginosis and urinary tract infections as a challenge to antibacterial therapy. A literature review

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