Vaginocervical stimulation-induced release of classical neurotransmitters and nitric oxide in the nucleus of the solitary tract varies as a function of the oestrus cycle

Guevara‐Guzmán, Rosalinda; Buzo, Enrique; Larrazolo, Arturo; Riva, C. de la; Costa, Ana P. da; Kendrick, Keith M.

doi:10.1016/s0006-8993(01)02207-7

Cited by 25 publications

(10 citation statements)

References 72 publications

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“…Nitric oxide is influenced by ovarian hormones (20,25). Regarding this possible nitrergic influence on endocervical secretion, oestrogen is necessary for priming the effector organ.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide increases endocervical secretion at the ovulatory phase in the female

Mörlin¹,

Hammarström²

2005

Acta Obstet Gynecol Scand

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“…Nitric oxide is influenced by ovarian hormones (20,25). Regarding this possible nitrergic influence on endocervical secretion, oestrogen is necessary for priming the effector organ.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide increases endocervical secretion at the ovulatory phase in the female

Mörlin¹,

Hammarström²

2005

Acta Obstet Gynecol Scand

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“…Nitric oxide is influenced by ovarian hormones (20,25). Regarding this possible nitrergic influence on endocervical secretion, oestrogen is necessary for priming the effector organ.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding this possible nitrergic influence on endocervical secretion, oestrogen is necessary for priming the effector organ. It could only be speculated about that also the amount of and sensitivity for NO could be changed during the reproductive cycle (20,25).…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide increases endocervical secretion at the ovulatory phase in the female

Mörlin

Hammarström

2005

Acta Obstet Gynecol Scand

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“…As vaginal stimulation prior to a behavioural experiment has been shown to influence learning and memory performance in female rodents [27]–[30], vaginal smears were obtained after the end of choice in each experiment. Sterile Q-tips were immersed in physiological saline and gently inserted into the vaginal tract to remove loose cells.…”

Section: Methodsmentioning

confidence: 99%

Social Investigation and Long-Term Recognition Memory Performance in 129S1/SvImJ and C57BL/6JOlaHsd Mice and Their Hybrids

Hädicke

Engelmann

2013

PLoS ONE

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When tested for their behavioural performance, the mixed genetic background of transgenic mice is a critical, but often ignored, issue. Such issues can arise because of the significant differences in defined behavioural parameters between embryonic stem cell donor and recipient strains. In this context, the commonly used stem cell donor strain ‘129’ shows ‘deficits’ in different paradigms for learning and long-term memory. We investigated the long-term social recognition memory performance and the investigative behaviour in commercially available 129S1/SvImJ and C57BL/6JOlaHsd mice and two F1-hybrids (129S1/SvImJ×C57BL/6JOlaHsd) by using the social discrimination procedure and its modification, the volatile fraction cage (VFC). Our data revealed an unimpaired olfactory long-term recognition memory not only in female and male 129S1/SvImJ and C57BL/6JOlaHsd mice but also in the two hybrid lines (129S1/SvImJxC57BL/6JOlaHsd) when the full ‘olfactory signature’ of the ‘to-be-recognized’ conspecific was presented. Under these conditions we also failed to detect differences in the long-term recognition memory between male and female mice of the tested strains and revealed that the oestrus cycle did not affect the performance in this memory task. The performance in the VFC, based only on the volatile components of the ‘olfactory signature’ of the ‘to-be-recognized’ conspecific, was similar to that observed under direct exposure except that females of one F1 hybrid group failed to show an intact long-term memory. Thus, the social discrimination procedure allowing direct access between the experimental subject and the stimulus animal(s) is highly suitable to investigate the impact of genetic manipulations on long-term memory in male and female mice of the strain 129S1/SvImJ, C57BL/6JOlaHsd and 129S1/SvImJxC57BL/6JOlaHsd hybrids.

show abstract

Vaginocervical stimulation-induced release of classical neurotransmitters and nitric oxide in the nucleus of the solitary tract varies as a function of the oestrus cycle

Cited by 25 publications

References 72 publications

Nitric oxide increases endocervical secretion at the ovulatory phase in the female

Nitric oxide increases endocervical secretion at the ovulatory phase in the female

Nitric oxide increases endocervical secretion at the ovulatory phase in the female

Social Investigation and Long-Term Recognition Memory Performance in 129S1/SvImJ and C57BL/6JOlaHsd Mice and Their Hybrids

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