Vaginoplasty with oxidized cellulose: anatomical, functional and histological evaluation

Dornelas, Juliane; Bella, Zsuzsanna Ilona Katalin de Jármy Di; Heinke, Thaís; Kajikawa, Marcio Masashi; Takano, Cláudia Cristina; Zucchi, Eliana Viana Monteiro; Girão, Manoel Joâo Batista Castello

doi:10.1016/j.ejogrb.2012.04.018

Cited by 26 publications

(27 citation statements)

References 20 publications

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“…Although all articles using oxidised, regenerated cellulose in the treatment of MRKHS are case series, the efficacy of this treatment is comparable with other materials used in the Abbé-McIndoe neovaginoplasty [17][18][19]. Since this synthetic mesh is easily available with low complications related to the material, we considered this an ideal approach for vaginal reconstruction [22].…”

Section: Discussionmentioning

confidence: 94%

Oestrogen receptor alpha expression in neovaginal tissue of women following modified Abbé-McIndoe technique and in premenopausal women

Kajikawa¹,

Bella²,

Dornelas³

et al. 2015

Gynecological Endocrinology

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The aim of the study was to compare the expression of oestrogen receptor alpha (ERα) in neovaginal tissue of patients with vaginal agenesis following neovaginoplasty using regenerated, oxidised cellulose in premenopausal women. A prospective, observational case-control study was performed on eight patients with vaginal agenesis following modified Abbé-McIndoe neovaginoplasty and 10 control premenopausal women following benign gynaecologic surgery. 6F11 monoclonal antibody was used to determine ERα expression in the vaginal mucosa. Quantitative and qualitative evaluations were performed, respectively, in vaginal epithelium and stroma. The thickness of the vaginal epithelium was determined as the vertical distance between the basal layer cells and the apical surface of the superficial layer. The percentage of ERα-expressing cells was higher in the control group, except in the superficial zone of the epithelium. In the stromal tissue, ERα was detected in only one patient from the neovagina group compared with nine women in the control group. The neovagina group had a statistically thinner epithelium. Our study suggests that women with vaginal agenesis following modified Abbé-McIndoe neovaginoplasty using regenerated oxidised, cellulose experience relatively local hypo-oestrogenism in the first year after surgery, with repercussion in vaginal trophism.

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Section: Discussionmentioning

confidence: 94%

Oestrogen receptor alpha expression in neovaginal tissue of women following modified Abbé-McIndoe technique and in premenopausal women

Kajikawa¹,

Bella²,

Dornelas³

et al. 2015

Gynecological Endocrinology

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“…The oxidized cellulose acts as a protective covering of the bloody surgical area, and it is no longer observed after the 3 rd postoperative month. [ 3 ] These properties permit vaginal epithelialization without adhesion between the prosthesis and newly dissected surface. After 6 months of follow-up, these neovaginas present histological characteristics such as a normal vagina, showing squamous epithelium, similar amounts of collagen, and the presence of androgen receptors.…”

Section: Discussionmentioning

confidence: 99%

“…Vaginoplasty with oxidized cellulose has been used by gynecologists as a surgical option in vaginal agenesis, with good cosmetic and functional results. [ 3 ] This surgical technique is not very widespread among pediatric surgeons. A case of MRKHS Type 1 that underwent vaginoplasty with oxidized cellulose is reported here.…”

Section: Introductionmentioning

confidence: 99%

Vaginoplasty with Oxidized Cellulose in Mayer–Rokitansky–Küster–Hauser Syndrome

Leite

Shida

Takano

2021

Journal of Indian Association of Pediatric Surgeons

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“…Instead of skin, other tissues have been used, such as human amnion [127], subcutaneous abdominal flaps [128], fasciocutaneous thigh flaps [129,130], labial skin flaps [131], and autologous in vitro cultured vaginal tissue [132]. Given that the use of skin grafts requires the intervention of plastic surgeons and is associated with longer operative times and visible scars, the use of oxidized cellulose and other biomaterials has been described with positive outcomes [133,134].…”

Section: The Mcindoe Operationmentioning

confidence: 99%