2013
DOI: 10.1097/wnr.0b013e32835f00a3
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Vagus somatosensory-evoked potentials are prolonged in patients with multiple sclerosis with brainstem involvement

Abstract: Vagus somatosensory-evoked potentials (VSEP) were proposed as a neurophysiological indicator of brainstem dysfunction based on prolonged latencies found in Alzheimer's dementia and Parkinson's disease. We now aimed at a further confirmation of this view independent from neurodegenerative diseases and hypothesized that VSEP in multiple sclerosis with brainstem affection show prolonged latencies, too. In 15 patients with multiple sclerosis according to McDonald and 15 healthy controls after stimulation of the au… Show more

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Cited by 10 publications
(18 citation statements)
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“…Yet, it is not always the full spectrum of P1-N1-P2 potentials that is delayed after tVNS. Only P1 latencies were also found to be prolonged in people suffering from multiple sclerosis, especially in those patients with known neurodegeneration at the brainstem (Polak, Zeller, Fallgatter, & Metzger, 2013). Furthermore, in people reporting to have experienced a worsening of their memory performance, only those who worried about this showed a prolonged P2 component (Hagen et al, 2015).…”
Section: Somatosensory Evoked Potentialsmentioning
confidence: 96%
“…Yet, it is not always the full spectrum of P1-N1-P2 potentials that is delayed after tVNS. Only P1 latencies were also found to be prolonged in people suffering from multiple sclerosis, especially in those patients with known neurodegeneration at the brainstem (Polak, Zeller, Fallgatter, & Metzger, 2013). Furthermore, in people reporting to have experienced a worsening of their memory performance, only those who worried about this showed a prolonged P2 component (Hagen et al, 2015).…”
Section: Somatosensory Evoked Potentialsmentioning
confidence: 96%
“…Although the available criteria for the diagnosis of multiple sclerosis do not require neurophysiological testing [1], many aspects of the disease can be shown mainly or solely using neurophysiological studies [2], [3], [4], [5], [6], [7], [8], [9], [10]. This is the case, for instance, with some forms of hyperactivity, such as the well-known facial myokymic discharges likely due to ectopic generation of activity in demyelinating perinuclear lesions [11], [12] and other neurophysiological manifestations of altered excitability in brain, brainstem or spinal cord [13], [14], [15].…”
Section: Introductionmentioning
confidence: 99%
“…The authors planned in the original studies to match patients and controls by age; however, it did not happen. 19-26 In fact, some of them stated that the age of patients and controls was “significantly different.” 19 We also found that studies reporting significant differences on the VSEP data between patients and their controls had a higher number of items scored as “yes” ( P < .039). The majority of “not” or points lost were in the design of the study, sample size justification, reliable and valid outcome measures, correct electrophysiological analysis of findings, dropout information, and appropriateness of conclusions (Table 2).…”
Section: Resultsmentioning
confidence: 99%
“…Grounding was mentioned in 4 studies, and it was done with a band electrode placed around the subject’s head right above the ears. 19,22,23,25 Three groups mentioned impedance values, and that was kept below 2 kΩ. 19,21,22…”
Section: Resultsmentioning
confidence: 99%