Val/Met Polymorphism of the COMT Gene Moderates the Association Between Job Strain and Early Atherosclerosis in Young Men

Hintsanen, Mirka; Elovainio, Marko; Puttonen, Sampsa; Kivimäki, Mika; Lehtimäki, Terho; Kähönen, Mika; Juonala, Markus; Rontu, Riikka; Viikari, Jorma; Raitakari, Olli T.; Keltikangas‐Järvinen, Liisa

doi:10.1097/jom.0b013e318165c7ec

Cited by 18 publications

(16 citation statements)

References 52 publications

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“…Two studies reported an association in males and not females. 29,30 Two other studies found the opposite to be true. 31,32 Differences in the WRS-CIMT association in males were found to be modified by a genetic factor.…”

mentioning

confidence: 84%

“…Hintsanen et al and Nordstrom et al found a relationship between work related stress and increased CIMT in males, but observed no association among females. 29,30 Conversely, two studies found a relationship between WRS and CIMT in females, but not males. 31,32 Differences in smoking, BMI, and hypertension across studies may explain these conflicting results.…”

Section: Summary Of Evidencementioning

confidence: 99%

“…Eight studies found positive associations with WRS. [25][26][27][28][29][30][31][32] Jedryka-Gó ral et al reported a statistically significant inverse association between WRS and CIMT. 33 Fujishiro et al reported an association between CIMT and job control, but not with job strain (Table 3).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Men with the VAL/VAL catechol-O-methyl transferase allele had increased CIMT in relation to WRS, while those with either the MET/MET or MET/VAL allele did not. 29 …”

mentioning

confidence: 99%

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Occupational stress and subclinical atherosclerosis: a systematic review

Wilson

Conroy

Dorevitch

2014

International Journal of Occupational and Environmental Health

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Background: Stress is a common hazard in the work environment and is associated with multiple adverse health effects. The association between work-related stress (WRS) and cardiovascular disease has been established in a number of epidemiological studies. Methods: A systematic review was conducted according to the PRISMA statement of the English literature involving WRS and carotid artery intima media thickness (CIMT). Results: Four cohorts and six cross-sectional studies of occupational stress and CIMT were identified. All cohorts and five of the cross-sectional studies reported a significant positive association, while one reported an inverse association of WRS and CIMT. Discussion: The weight of the evidence that we were able to identify suggests that occupational stress results in an increased risk of atherosclerosis, assessed via CIMT. Studies that include longitudinal measures of stress and intermediate cardiac endpoints, with adequate accounting for confounders, are needed. Interventional studies should also be conducted to determine whether CIMT progression can be prevented with workplace stress reduction.

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mentioning

confidence: 84%

Section: Summary Of Evidencementioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…Men with the VAL/VAL catechol-O-methyl transferase allele had increased CIMT in relation to WRS, while those with either the MET/MET or MET/VAL allele did not. 29 …”

mentioning

confidence: 99%

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Occupational stress and subclinical atherosclerosis: a systematic review

Wilson

Conroy

Dorevitch

2014

International Journal of Occupational and Environmental Health

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“…the mean age of the women was 52.8 yr, but the job demand was assessed by only 3 items which may not have reflected the job stress adequately leading to null findings. Recently, some studies reported that certain genotypes moderate the association between job stress and the risk of CHD 34,35) . It may be important to explore whether different races have genotypic variation that may moderate this association.…”

Section: Discussionmentioning

confidence: 99%

Job Stress and Carotid Intima‐media Thickness in Chinese Workers

Hang

Cao

et al. 2010

Journal of Occupational Health

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Job Stress and Carotid Intima-media Thickness in Chinese Workers: Weixian XU, et al. Department of Cardiology, Peking University ThirdHospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, China-Objectives: Carotid intima-media thickness (CIMT) can be used as a surrogate marker for cardiovascular health, and job stress is a risk factor for cardiovascular disease. However, there have been a limited number of studies focusing on the association between job stress and CIMT. The goal of this study was to explore the association between job stress and CIMT in a Chinese working population. Methods: The study included 734 participants (508 males and 226 females) without coronary heart disease. Job stress was evaluated using the effort-reward imbalance (ERI) questionnaire at work. ERI is the ratio between efforts and rewards (weighted by number of items). High resolution carotid ultrasonographic studies were performed using a Sequoia 512 ultrasound system with an 8-13 MHz linear array transducer to assess CIMT. Results: This study detected gender-specific associations between the indictors of the ERI model and increased CIMT among the study participants in China. This study demonstrated a robust association in women between the key indicators of ERI, effort, overcommitment and ERI, and increased CIMT (adjusted r 2 =0.258, p=0.001; adjusted r 2 =0.261; p<0.001; adjusted r 2 =0.274; p<0.001, respectively). Reward was inversely correlated with CIMT (adjusted r 2 =0.282, p<0.001), controlling for age, hypertension, diabetes mellitus, hyperlipidaemia and body mass index. For men, a similar pattern of associations was observed, but the associations were lost after adjustment for confounders. Conclusions: Our resultsshow that effort, overcommitment and ERI may be associated with early atherosclerosis predicted by CIMT in women, and reward is inversely related to CIMT. (J Occup Health 2010; 52: 257-262)

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Job Demand/Control/Strain

Theorell¹

2018

Encyclopedia of Behavioral Medicine

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Val/Met Polymorphism of the COMT Gene Moderates the Association Between Job Strain and Early Atherosclerosis in Young Men

Abstract: Our findings support a general model in which the interaction between genotype and job strain is assumed to predispose to increased atherosclerotic processes.

Cited by 18 publications

References 52 publications

Occupational stress and subclinical atherosclerosis: a systematic review

Occupational stress and subclinical atherosclerosis: a systematic review

Job Stress and Carotid Intima‐media Thickness in Chinese Workers

Job Demand/Control/Strain

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