Val66Met polymorphism in the <i>BDNF</i> gene in children with bronchial asthma

Jeseňák, Miloš; Babušíková, Eva; Evinová, Andrea; Bánovčin, Peter; Dobrota, Dušan

doi:10.1002/ppul.23065

Cited by 15 publications

(9 citation statements)

References 35 publications

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“…Furthermore, our results showed that the G allele of rs6265 is overrepresented in CA subjects, compared to the healthy controls. Similarly, a recent study demonstrated an association between this polymorphism and CA in a Slovakian population, and established the G allele as a risk factor for CA (Jesenak et al, 2014). This study confirmed the association of this putative functional polymorphism with CA in a Chinese Han population.…”

Section: Discussionsupporting

confidence: 74%

“…Increased levels of BDNF in blood, broncho-alveolar lavage fluid, and nasal lavage fluid have been positively correlated with increased disease activity and severity in patients with asthma (Muller et al, 2010). Our results provide direct evidence of a link between a genetic change in BDNF and CA incidence, and proposed the variants that may affect the development of CA (Jesenak et al, 2014).…”

Section: Discussionsupporting

confidence: 50%

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Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma

Jy¹,

Al²,

Zl³

2015

Genet. Mol. Res.

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ABSTRACT. Brain-derived neurotrophic factor (BDNF) promotes synaptic remodeling and modulates the function of other neurotransmitters. Allergic inflammation triggers neuronal dysfunction and structural changes in the airways. Genetic polymorphisms in functional regions of the BDNF gene have a plausible role in modulating the risk of child asthma (CA). This study examined the potential association between CA and three single nucleotide polymorphisms (SNPs) in BDNF (rs2030323, rs6265, and rs16917204 in the promoter, exon 4, and 3'-untranslated regions, respectively). The study was conducted in 350 children with asthma and 356 healthy controls. The genotype and allele frequencies and difference between groups were analyzed using HaploView 4.0 and SPSS 20.0 software platforms. The analysis revealed a strong association between the rs6265 genotype distribution and CA. The frequency of the G allele was significantly higher 16233-16240 (2015) in CA patients than in healthy controls (P = 0.0007, odds ratio = 1.323, 95% confidence interval = 1.073-1.632). Strong linkage disequilibrium was observed between rs16917204 and rs6265. A significantly higher number of G-G haplotypes were observed in CA patients than in controls (P = 0.024 after Bonferroni correction), while the G-A haplotypes were more significant in controls (P = 0.013 after Bonferroni correction). This suggested that BDNF gene polymorphisms confer susceptibility to CA, and also support the notion that BDNF dysfunction is involved in the pathophysiological process of CA.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 50%

Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma

Jy¹,

Al²,

Zl³

2015

Genet. Mol. Res.

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“…The regulated secretion of neurotrophins in these cells is under the control of intracellular Ca 2+ 53,55 and cAMP 56. Moreover, the Val66Met polymorphism in the BDNF gene has been linked to pathological conditions in the airways such as asthma;57,58 whether this polymorphism affects the secretion of BDNF as in neuronal cells needs further investigation.…”

Section: Secretion Of Neurotrophins From Non-neuronal Tissuesmentioning

confidence: 99%

Mechanisms and regulation of neurotrophin synthesis and secretion

Qudah

Al‐Dwairi

2016

NSJ

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Neurotrophins are secreted proteins that are synthesized as pre-pro-neurotrophins on the rough endoplasmic reticulum, which are subsequently processed and then secreted as mature proteins. During synthesis, neurotrophins are sorted in the trans-Golgi apparatus into 2 pathways of secretion; the constitutive and the regulated pathways. Neurotrophins in the constitutive pathway are secreted cautiously without any trigger, while in the regulated pathway of secretion an external stimulus elevates the calcium concentration intracellularly leading to neurotrophin release. The regulation of sorting and secretion of neurotrophins is critical for several processes in the body, such as synaptic plasticity, neurodegenerative disorders, demyelination disease, and inflammation. The purpose of this review is to summarize the current mechanisms of neurotrophin sorting and secretion.

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“…The association of rs6265‐T with ileal disease location might therefore be due to earlier smoking in our rs6265‐T patients, triggering and shaping an immunological response at a vulnerable age. Interestingly, rs6265‐T enhanced protective effects of smoking in melanoma and increased the risk of childhood asthma . Several lines of evidence also indicate a direct role of brain‐derived neurotrophic factor (BDNF) on the immune and nervous system of the gut .…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease

Lang

Biedermann

Haaften

et al. 2017

Aliment Pharmacol Ther

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Val66Met polymorphism in the BDNF gene in children with bronchial asthma

Abstract: Specific BDNF gene polymorphism may contribute to bronchial asthma susceptibility. Our study suggested the positive association between selected functional BDNF polymorphism (rs6265) and asthma in children.

Cited by 15 publications

References 35 publications

Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma

Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma

Mechanisms and regulation of neurotrophin synthesis and secretion

Genetic polymorphisms associated with smoking behaviour predict the risk of surgery in patients with Crohn's disease

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