2014
DOI: 10.1016/j.jep.2013.11.017
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Valeriana amurensis improves Amyloid-beta 1-42 induced cognitive deficit by enhancing cerebral cholinergic function and protecting the brain neurons from apoptosis in mice

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Cited by 39 publications
(28 citation statements)
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“…Two new iridoids, jatamanvaltrates N ( 29 ) and O ( 30 ), were also extracted from the roots of V. jatamansi (Xu, Guo, Fang, Li, & Guo, ). Similarly, Wang et al () reported the occcurance of two iridoids, jatamanvaltrates P ( 31 ) and Q ( 32 ), along with three known iridoids, valtrate ( 1 ), rupesin B ( 33 ), and chlorovaltrate ( 34 ) from the roots and rhizomes of V. jatamansi . Three new iridoids, namely, valeriandoids A ( 35 ), B ( 36 ), and C ( 37 ) have been isolated from the roots of this species (Xu et al, ).…”
Section: Valepotriatesmentioning
confidence: 85%
“…Two new iridoids, jatamanvaltrates N ( 29 ) and O ( 30 ), were also extracted from the roots of V. jatamansi (Xu, Guo, Fang, Li, & Guo, ). Similarly, Wang et al () reported the occcurance of two iridoids, jatamanvaltrates P ( 31 ) and Q ( 32 ), along with three known iridoids, valtrate ( 1 ), rupesin B ( 33 ), and chlorovaltrate ( 34 ) from the roots and rhizomes of V. jatamansi . Three new iridoids, namely, valeriandoids A ( 35 ), B ( 36 ), and C ( 37 ) have been isolated from the roots of this species (Xu et al, ).…”
Section: Valepotriatesmentioning
confidence: 85%
“…In the brain, NSE is concentrated exclusively in the cytoplasm of neurons (10) and has been suggested to be a specific serum marker for neuronal damage. In the results of the present study, the reduction of NSE expression in the brain tissues of the mice treated with SP plus B7-H3 may reflect the following: i) NSE is primarily localized in the cytoplasm of neurons (10) and is not secreted; thus, an increase in its levels in the CSF or blood indicates structural damage of neuronal cells (8); ii) The number of existing functional neurons in the brain tissues that are available to be stained as NSE-positive by immunohistochemical analysis is markedly decreased due to apoptosis or necrosis caused by multiple factors exerting injurious effects, including exacerbated inflammation in (5), oxidative stress, lipid peroxidation, mitochondrial damage and BBB breakdown (1). Further reductions in NSE expression in brain tissues in response to combined SP and B7-H3 challenge indicate a greater degree of neuronal loss and structural neuronal damage, which is consistent with our previous study where it was identified that B7-H3 exacerbated the SP infection-induced proinflammatory response and BBB disruption (6).…”
Section: Discussionmentioning
confidence: 64%
“…Brain samples fixed with 4% formalin were routinely processed, and embedded in paraffin. Sections (4 µm) were cut using a microtome (Leica Biosystems GmbH, Wetzlar, Germany), and neuronal loss and cell apoptosis in the cortex were evaluated by Nissl and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining (8). Normal neurons were identified by the presence of Nissl bodies in the cytoplasm, loose chromatin and prominent nucleoli.…”
Section: Sp-induced Meningitis In Micementioning
confidence: 99%
“…The neuropathologic features of the disease including extracellular senile plaques, intracellular neurofibrillary tangles as well as neuronal loss in some brain areas including hippocampal area (Majlessi et al, 2012). One of the key events observed in the neuropathogenesis of AD is Aβ protein deposition and the amyloid plaques formation of in the brain (Wang et al, 2014). Aβ is a 39-43 amino acid peptide that is the result of proteolysis of amyloid precursor protein by β and γ-secretases and the Aβ 1-42 is the most neurotoxic fragment of this peptide (Lambert et al, 1998).…”
Section: Discussionmentioning
confidence: 99%