2013
DOI: 10.1016/j.exger.2013.09.002
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Valeriana officinalis extract and its main component, valerenic acid, ameliorate d-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation

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Cited by 43 publications
(41 citation statements)
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“…18 It has been reported that treatment with 450 and 900 mg VE causes hypnotic effects in people, 19 but the dosage used in the present study was consistent with a previous study in mice. 18 The animals were divided into four groups as follows: (1) sham-operated (Control group), (2) vehicle-treated ischemia (Vehicle group), (3) 25 mg/kg VE-treated ischemia (VE25 group), and (4) 100 mg/kg VE-treated ischemia group (VE100 group). Vehicle or VE was orally administered to gerbils once a day for 3 weeks before the ischemic surgery.…”
Section: Ve Treatmentsupporting
confidence: 82%
See 1 more Smart Citation
“…18 It has been reported that treatment with 450 and 900 mg VE causes hypnotic effects in people, 19 but the dosage used in the present study was consistent with a previous study in mice. 18 The animals were divided into four groups as follows: (1) sham-operated (Control group), (2) vehicle-treated ischemia (Vehicle group), (3) 25 mg/kg VE-treated ischemia (VE25 group), and (4) 100 mg/kg VE-treated ischemia group (VE100 group). Vehicle or VE was orally administered to gerbils once a day for 3 weeks before the ischemic surgery.…”
Section: Ve Treatmentsupporting
confidence: 82%
“…41,42 In our previous study, we demonstrated that VE decreased lipid peroxidation in a model of aging induced by d-galactose. 18 In the present study, HNE levels peaked at 3 h after ischemia/ reperfusion and decreased with time. We observed that VE treatment lowered HNE levels, and we hypothesize that this might contribute to the increased survival of pyramidal neurons in the gerbil hippocampus.…”
Section: Discussionmentioning
confidence: 69%
“…D-galactose (D-gal) has been used to induce aging in mice for brain aging or anti-aging pharmacological research because the D-gal-induced brain aging processes in mice resemble those in humans [8][9][10][11]. The molecular mechanisms of D-gal-induced brain aging involve the production of reactive oxygen species (ROS) and subsequent ROS-induced mitochondrial dysfunction [12].…”
Section: Introductionmentioning
confidence: 99%
“…In order to explain the mechanism of D-galactose, many hypotheses have been put forward; one of them is that chronic systemic exposure to D-galactose increases levels of MDA and lipofuscin and also decreases GPx and SOD activities (6,41). In our study, when the Morris water maze test was applied, we observed that long-term administration of D-galactose in mice caused cognitive deficit and showed significant impairment of learning and memory ability.…”
Section: Discussionmentioning
confidence: 66%