Valeur Du Test De Provocation Par Allergenes Inhales Dans l'ASTHME

Gayrard, P; Orehek, J; Boutin, C.; Charpin, J

doi:10.1111/j.1398-9995.1972.tb01407.x

Cited by 5 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are in marked contrast to those obtained with the intradermal method of skin testing where positive bronchial responses have been found in a variable percentage of patients with positive intradermal skin tests and in from I";, to 40% of patients in whom skin reactivity was classed as negative (Nilsson & Kaude, 1960;Colldahl. 1967;Aas, 1970;Maier, Orion & Deviller, 1970;Gayrard et al, 1972). However, as intradermal tests tend to produce more nonspecifically positive reactions than do prick tests (Pepys, 1972), as the criteria that were used in these studies to define positive cutaneous and bronchial responses differed, and as the degree of control over those variables which influence the assessment of cutaneous and bronchial reactivity varied widely, these differences in the observed relationship between the allergic reactivity of the skin and the bronchi are not surprising.…”

Section: Discussionmentioning

confidence: 99%

The correlation between skin tests, bronchial provocation tests and the serum level of IgE specific for common allergens in patients with asthma

Bryant

Burns

Lazarus

1975

Clin Experimental Allergy

127

View full text Add to dashboard Cite

Summary Cutaneous and bronchial immediate allergic reactivity and the serum level of IgE specific for each of four common inhalant allergens were determined for 153 asthmatic patients. Positive bronchial reactivity to an extract was not detected in any of the patients with a negative prick test reaction to that extract but did occur in 9% of the patients in whom the serum tests results for IgE specific to that allergen fell within the range regarded as negative. Highly significant correlation coefficients between the degree of bronchial and cutaneous allergic reactivity to the allergen extracts were found and these were slightly but significantly less than the correlation between the serum level of allergen specific IgE and the degree of bronchial allergic reactivity to the allergen extracts. These findings indicate that the results both of prick testing with appropriate extracts and estimation of the serum level of allergen specific IgE can be used to predict not only the presence of detectable bronchial reactivity to inhalant allergens but also the degree of this reactivity. However, for the routine investigation of asthmatic patients measurement of the serum level of allergen specific IgE would appear to have little advantage over properly performed prick tests.

show abstract

Section: Discussionmentioning

confidence: 99%

The correlation between skin tests, bronchial provocation tests and the serum level of IgE specific for common allergens in patients with asthma

Bryant

Burns

Lazarus

1975

Clin Experimental Allergy

127

View full text Add to dashboard Cite

show abstract

“…Comparative studies have established that this bronchial effect was related to the ~-blocking potency and selectivity of the drugs [13,14]. These early studies also suggested that induced bronchoconstriction was more pronounced in more severe asthma [2,15]. Recently, it has been demonstrated that dl-propranolol hydrochloride (P) can be safely administered by inhalation in a stepwise manner [15][16][17][18][19], and that it induces a dose-dependent bronchoconstriction [17][18][19] .…”

mentioning

confidence: 99%

“…These early studies also suggested that induced bronchoconstriction was more pronounced in more severe asthma [2,15]. Recently, it has been demonstrated that dl-propranolol hydrochloride (P) can be safely administered by inhalation in a stepwise manner [15][16][17][18][19], and that it induces a dose-dependent bronchoconstriction [17][18][19] . However, clinical and physiological factors which influence bronchial responsiveness to propranolol in asthmatic patients are poorly understood.…”

mentioning

confidence: 99%

Bronchial responsiveness to inhaled propranolol in asthmatic children and adults

Foresi¹,

Chetta²,

Pelucchi³

et al. 1993

Eur Respir J

View full text Add to dashboard Cite

Inhaled propranolol (P) was administered to a population which included asthmatic children (30 subjects) and adults (43 subjects): 1) to investigate the determinants of induced bronchial response; 2) to examine the relationship with treatment requirements; 3) to determine the relationship with responsiveness to methacholine (M) and ultrasonically nebulized distilled water (UNDW) (50 subjects); and 4) to establish the short-term repeatability of bronchial response to propranolol compared with methacholine (22 subjects). Bronchial response to propranolol and methacholine was expressed as the cumulative provocative dose (PD20 in mumol) and responsiveness to UNDW as the provocative output (PO20 in ml.min-1) producing a 20% fall in forced expiratory volume in one second (FEV1). Response to propranolol was significantly related to the degree of responsiveness to methacholine, but not to age, gender, presence of atopy, age at asthma onset, or baseline FEV1. PD20P was measurable in all but three subjects. A significant difference in mean PD20M but not in PD20P was found between subjects requiring more anti-asthmatic treatments compared to those without therapy. The difference between geometric mean PD20P and geometric mean PD20M was 14.1. PO20UNDW was measurable in only 21 out of 50 subjects. Both PD20P and PD20M were significantly lower in responders to UNDW than in nonresponders. Reproducibility of PD20P was comparable to that of PD20M (coefficients of repeatability: 1.17 and 1.09). We conclude that bronchial responsiveness to propranolol is safely measurable in most children and adults with asthma. Repeatability of bronchial response to propranolol is comparable to that of methacholine. Moreover, responsiveness to propranolol is not a predictor of treatment requirement.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Diagnostic tests in ragweed-allergic asthma *1A comparison of direct skin tests, leukocyte histamine release, and quantitative bronchial challenge

Bruce

Rosenthal

Lichtenstein

et al. 1974

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

Valeur Du Test De Provocation Par Allergenes Inhales Dans l'ASTHME

Cited by 5 publications

References 28 publications

The correlation between skin tests, bronchial provocation tests and the serum level of IgE specific for common allergens in patients with asthma

The correlation between skin tests, bronchial provocation tests and the serum level of IgE specific for common allergens in patients with asthma

Bronchial responsiveness to inhaled propranolol in asthmatic children and adults

Diagnostic tests in ragweed-allergic asthma *1A comparison of direct skin tests, leukocyte histamine release, and quantitative bronchial challenge

Contact Info

Product

Resources

About