Valganciclovir treatment of primary cytomegalovirus pneumonitis in an immunocompetent adult

Snape, Susan; Venkatesan, Pradhib

doi:10.1136/bcr.11.2010.3489

Cited by 8 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These agents may have major side effects, including myelosuppression and potential carcinogenicity. However, untreated CMV disease is associated with considerable morbidity and mortality, and published case studies and reviews provide consistent case‐based evidence of rapid clinical improvement after commencement of therapy in this clinical setting 3 , 11 , 17 , 21 . ‐ 23 Furthermore, a recent study found ganciclovir to be a safe and effective treatment for CMV‐associated pneumonia in immunocompetent children 24 .…”

Section: Treatment Of CMV Disease In Immunocompetent Adultsmentioning

confidence: 84%

Cytomegalovirus disease in immunocompetent adults

Lancini

Faddy

Flower

et al. 2014

Medical Journal of Australia

106

View full text Add to dashboard Cite

Cytomegalovirus (CMV) is a highly prevalent and globally distributed virus. CMV infection in healthy adults is usually asymptomatic or causes a mild mononucleosis-like syndrome. CMV disease causes significant morbidity and mortality in neonates and severely immunocompromised adults. CMV disease can present with a wide range of manifestations, with colitis being the most common. The incidence of severe CMV disease in immunocompetent adults appears to be greater than previously thought, which may be partly due to immune dysfunction related to comorbidities such as kidney disease or diabetes mellitus. CMV disease can mimic an array of alternative diagnoses and pose a significant diagnostic challenge, especially in immunocompetent adults, leading to delayed diagnosis, adverse health outcomes and unnecessary financial expense. Non-invasive testing for CMV is widely available and can facilitate early diagnosis if used appropriately. Although limited, current evidence suggests that targeted antiviral therapy with ganciclovir or valganciclovir is appropriate for severe CMV disease in immunocompetent adults.

show abstract

Section: Treatment Of CMV Disease In Immunocompetent Adultsmentioning

confidence: 84%

Cytomegalovirus disease in immunocompetent adults

Lancini

Faddy

Flower

et al. 2014

Medical Journal of Australia

106

View full text Add to dashboard Cite

show abstract

“…Treatment with ganciclovir was initiated, after which our patient clinically improved. Several studies showed that only a few doses of antiviral medications are required to influence the course of disease [ 6 , 7 ]. Early recognition and initiation of ganciclovir in our patient successfully reduced the patient’s oxygen requirements and ultimately avoided intubation and intensive care unit (ICU) level of care.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus and Herpes Simplex Virus Co-Infection in an HIV-Negative Patient: A Case Report

Gangemi¹,

Choi²,

Yin³

et al. 2021

Cureus

View full text Add to dashboard Cite

Herpes simplex virus (HSV) and cytomegalovirus (CMV) infections are commonly seen in immunocompromised patients, particularly in patients with HIV. However, fulminant CMV infection and concurrent infection with HSV and CMV in non-HIV patients are quite rare. We present the case of a 72year-old HIV-negative man with a history of oropharyngeal carcinoma in remission and recent treatment of immune thrombocytopenic purpura with high-dose steroids who was transferred from an outside hospital for Ear Nose and Throat (ENT) evaluation of a non-healing buccal ulcer. During initial presentation, the patient was found to be febrile with acute hypoxic respiratory failure and a chest x-ray suggestive of bacterial pneumonia, though he failed to improve with broad-spectrum antibiotic therapy. He underwent esophagogastroduodenoscopy for dysphagia, which revealed a discrete ulcer positive for CMV. Biopsy of his buccal lesion was ultimately positive for HSV-1 and HSV-2. The patient's clinical status improved significantly following the initiation of antiviral therapy. It is important to consider CMV infection in the setting of persistent fever, respiratory distress, or dysphagia in the non-HIV infected patient, especially in the setting of prolonged steroid use. CMV and HSV infection can occur simultaneously at distinct sites in the body, and CMV infection may predispose to HSV reactivation due to its long term effect on cell-mediated immunity. Early recognition of opportunistic infections and initiation of antiviral therapy in immunocompromised patients can greatly affect length of hospital stay, morbidity, and, ultimately, mortality.

show abstract

“…3,5,10 Immunocompetent individuals often do not need antiviral treatment; however, in case of severe clinical manifestations, they have been considered by some authors who reported favorable results in terms of clinical improvement. 5,[17][18][19] A meta-analysis of CMV colitis in immunocompetent hosts 20 showed that mortality rate was higher in males, patients with chronic diseases, and older than 55 years. Based on this, they suggested the use of antiviral therapy in these patient groups rather than in immunocompromised ones.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus-Related Gastritis in an Immunocompetent Host Presenting With Infectious Gastroparesis

Solito,

Vadalá di Prampero,

Bulajic

et al. 2023

ACG Case Rep J

View full text Add to dashboard Cite

Cytomegalovirus (CMV) infection is usually asymptomatic or causes a mild mononucleosis-like syndrome, whereas severe symptoms are rarely reported. We report a case of a 70-year-old woman who was admitted to our center because of severe clinical presentation with anorexia, epigastric pain, nausea, postprandial vomiting, and significant weight loss. Esophagogastroduodenoscopy with biopsies showed ulcerative chronic gastritis with scattered large cells with inclusion bodies. Immunohistochemistry and polymerase chain reaction for CMV-DNA resulted positive. A gastric emptying of solid scintigraphy showed severe gastroparesis. The patient was discharged after 2 months of antiviral therapy completely asymptomatic. To the best of our knowledge, this is the first case of CMV-related gastroparesis in an immunocompetent patient, successfully treated with antiviral therapy.

show abstract

Valganciclovir treatment of primary cytomegalovirus pneumonitis in an immunocompetent adult

Cited by 8 publications

References 11 publications

Cytomegalovirus disease in immunocompetent adults

Cytomegalovirus disease in immunocompetent adults

Cytomegalovirus and Herpes Simplex Virus Co-Infection in an HIV-Negative Patient: A Case Report

Cytomegalovirus-Related Gastritis in an Immunocompetent Host Presenting With Infectious Gastroparesis

Contact Info

Product

Resources

About