“…However, relatively little work has been done on the case in which parameters are given by intervals. In the work described here, we will use a recently developed solver for parametric ODEs (Lin and Stadtherr, 2007) called VSPODE (Validating Solver for Parametric ODEs), which is used to produce guaranteed bounds on the solutions of nonlinear dynamic systems with interval-valued initial states and parameters. Both COSY VI and VSPODE use Taylor models (Makino and Berz, 1996;Makino and Berz, 1999;Makino and Berz, 2003), though in different ways, to deal with the uncertain quantities (parameters and initial values).…”