Validated spectrophotometric methods for determination of sodium valproate based on charge transfer complexation reactions

Belal, Tarek S.; El-Kafrawy, Dina S.; Mahrous, Mohamed S.; Abdel-Khalek, Magdi M.; Abo-Gharam, Amira H.

doi:10.1016/j.saa.2015.11.008

Cited by 34 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, several previous studies have concluded that complexation between electron-rich compounds and PA occurs through intermolecular hydrogen bonding [40][41][42] .…”

Section: Fig 2: Electronic Spectra Of Dnsa Mbz and [Mbz-dnsa] Complmentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

This article presents the development of a direct, simple and sensitive spectrophotometric method for the quantitative analysis of mebendazole (MBz), an anthelmintic medication in its pure and pharmaceutical forms. The method is based on the charge transfer (CT) interactions between MBz, an electron donor, and chloranilic acid (CA), 3,5dinitrosalicylic acid (DNSA), and picric acid (PA), (all of which are acceptors). The products of the CT reactions exhibit new absorption bands at 409 and 310 nm for CA and DNSA in methanol, respectively, and at 402 nm for PA in dichloroethane. Following the optimization of the experimental conditions, linearity ranges for MBz concentrations of 2.00-120, 1.00-40.0 and 2.00-25.0 µg mL-1 were achieved for CA-MBz, DNSA-MBz, and PA-MBz, respectively. Furthermore, the limits of detection (LOD) and quantification (LOQ) were calculated. The method was used to determine the MBz concentrations of tablets with good accuracy and precision and without interference from common tablet excipients. INTRODUCTION: Mebendazole (MBz), i.e., methyl [5-benzol-1H-benzoimidazole-2-yl] carbamate Scheme 1, is a broad spectrum anthelmintic drug widely used against hookworm, pinworm, roundworm, tapeworm, threadworm and mixed infestations. Furthermore, MBz is widely used against gastrointestinal helminths in both humans and animals 1, 2. The most common global diseases are helminthic, and they cause a variety of serious health problems and impact child growth by causing anemia and other nutritional deficiencies 3. Thus, the World Health Organization (WHO) categorize MBz as an essential medicine in its capacity as a single-dose treatment for helminthic infections 4 .

show abstract

“…Additionally, several previous studies have concluded that complexation between electron-rich compounds and PA occurs through intermolecular hydrogen bonding [40][41][42] .…”

Section: Fig 2: Electronic Spectra Of Dnsa Mbz and [Mbz-dnsa] Complmentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

show abstract

“…The range of RE % value demonstrates the high accuracy of the chemosensor LBT as were indicated in Table (2). To compute the precision, the assays were repeated three times within the day to determine the repeatability (intra-day precision) and three times on different days to determine the intermediate precision (inter-day precision) of the method [1,31]. The range of percentage relative standard deviation error (RSD %) values for both intra-day and inter-day precisions were indicating high precision of the chemosensor LBT for UO 2 2+ determination as were listed in Table( 2).…”

Section: Accuracy and Precisionmentioning

confidence: 99%

Spectrophotometric Determination of UO22+ by a New Chemosensor Labetalol Hydrochloride

Elhefnawy

Elabd

2018

Arab Journal of Nuclear Sciences and Applications

View full text Add to dashboard Cite

This work presents a new chemosensor Labetalol (LBT) hydrochloride 5-[1-hydroxy-2-(1-methyl-3phenylpropylamino)ethyl] salicylamide hydrochloride (LBT) was applied for spectrophotometric determination of UO 22+ in aqueous solution. The chemosensor LBT react with UO 2 2+ forming a new complex UO 2 2+ /LBT at wavelength of 314 nm. The absorbance of the linear calibration curve increases by increasing UO 2 2+ concentration at linear range of (1.0 -16.1) × 10 −6 mol L -1 with a correlation coefficient (R 2 = 0.998). The experimental conditions affecting the absorbance development were studied and optimized. The complexes stoichiometry was measured at the absorbance spectra 314 nm and the results were found to be 1:1 (metal: ligand) ratio. The present chemosensor LBT was effectively validated with respect to linearity, precision, accuracy, detection and quantification limits. For more accurate analysis, the apparent molar absorptivity, Beer's law, Ringbom and Sandell's sensitivity have been studied. The results of analysis were statistically compared with those obtained by ICP-OES as a reference method show that, the Student's t-and F-values at 95% confidence level are less than the theoretical values, which confirmed that there is no significant difference between the chemosensor LBT and the reference method in the same studied conditions. The chemosensor LBT provide a simple, sensitive and inexpensive spectrophotometric determination without any complicated equipment. It was also successfully applied for the direct determination of UO 2 2+ in different aqueous samples with satisfactory results.

show abstract

“…A great deal of research has been dedicated to CT interactions due to their wide range of applications in the fields of chemistry, biology, physics, biochemistry, medicine, pharmacology, material science, and industrial technology [ [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] ]. Specifically, in the pharmacology and biochemistry fields, CT interactions contribute to the study of antimicrobial, antitumorigenic, and anti-inflammatory agents, binding mechanisms of pharmaceutical receptors, the thermodynamics and pharmacodynamics of clinical candidate compounds, DNA binding, enzymatic reactions, drug delivery, and quantitively characterizing pharmaceuticals [ [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] ]. In the fields of material engineering and technology, CT interactions facilitate the development and optimization of solar energy storage devices, organic solar cells, organic semiconductors, electrical conductors, biosensors, optoelectronics, non-linear optical materials, optical communication, photocatalysts, dendrimers, and several other magnetic, optical, and electrical technologies [ [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] ,…”

Section: Introductionmentioning

confidence: 99%