Validated spectrophotometric methods for simultaneous determination of nebivolol hydrochloride and valsartan in their tablet

Application of two different spectrophotometric approaches for the determination of a new antihypertensive combination: Graphical and statistical representation of the data

“…The advanced concentration value method is a new approach derived from concentration value method which eliminate the use of regression equation and lets the recording of the concentration of the studied drug directly throw the spectrum with good accuracy and precision. The developed methods simple, accurate and also have the advantage of didn't require preceding treatment, complicated steps or use of organic harmful solvents like that usually used in the reported methods HPLC [9][10][11][12][13][14][15][16][17], LC-MS/MS [18], and spectrophotometry [19][20][21]. Although the use of ACV was easier and lower the manipulation steps, but in CC, obtaining the zero-order absorption spectrum ensures the drug profile and working at λmax ensured maximum accuracy and precision.…”

“…During the literature survey, many methods were found for the analysis of both NEB and VAL in its combined dosage form. Those methods include HPLC [9][10][11][12][13][14][15][16][17], LC-MS/MS [18], and spectrophotometry [19][20][21]. The aim of the study is to apply different approaches to determine the drug studied in its zeroorder absorption spectrum without interference from one another.…”

Figure 13 from: Peleshok K, Bondar B, Kryskiw L, Kucher T, Poliak O, Logoyda L (2021) Development and Validation of Spectrophotometric Methods for Estimation of Valsartan in Tablet Dosage Form. Pharmacia 68(4): 852-858. https://doi.org/10.3897/pharmacia.68.e73559

“…The scientific literature describes methods for quantitative determination of valsartan by spectrophotometry -by intrinsic light absorption (Tatar and Sağlık 2002;Kumar et al 2011;Gupta et al 2010;Tajane 2018;Jadhav et al 2014;Lotfya et al 2015;Kamal et al 2020;Drapak et al 2019aDrapak et al , 2019b and by reaction products with different reagents (Ramachandran et al 2011;Omar et al 2011). Indian scientists have been developed spectrophotometric methods for the determination of valsartan and ezetimibe in drugs using sulfophthaleine dyes such as bromophenol blue and bromocresol green (Ramachandran et al 2011).…”

Figure 9 from: Peleshok K, Bondar B, Kryskiw L, Kucher T, Poliak O, Logoyda L (2021) Development and Validation of Spectrophotometric Methods for Estimation of Valsartan in Tablet Dosage Form. Pharmacia 68(4): 852-858. https://doi.org/10.3897/pharmacia.68.e73559

“…The scientific literature describes methods for quantitative determination of valsartan by spectrophotometry -by intrinsic light absorption (Tatar and Sağlık 2002;Kumar et al 2011;Gupta et al 2010;Tajane 2018;Jadhav et al 2014;Lotfya et al 2015;Kamal et al 2020;Peleshok et al 2021;Drapak et al 2019aDrapak et al , 2019b and by reaction products with different reagents (Ramachandran et al 2011;Omar et al 2011). Indian scientists have been developed spectrophotometric methods for the determination of valsartan and ezetimibe in drugs using sulfophthaleine dyes such as bromophenol blue and bromocresol green (Ramachandran et al 2011).…”