Validated thoracic vertebrae and costovertebral joints increase biofidelity of a human body model in hub impacts

Aira, Jazmine; Guleyupoglu, Berkan; Jones, Derek A.; Koya, Bharath; Davis, Matthew L.; Gayzik, F. Scott

doi:10.1080/15389588.2019.1638511

Cited by 10 publications

(3 citation statements)

References 20 publications

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“…Age- and level-specific material properties were assigned to the anatomical structures in each PS-FE model, shown in Table 2 . The values for each mechanical property were obtained from published adult values which were adjusted based on chronological age-based scale factors [ 22 , 36 – 40 ]. A comprehensive table of level-specific material properties of spinal ligaments are reported in the Appendix of previous work from our lab [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

Section: Assignment Of Patient Age-and Level-specific Materials Prope...mentioning

confidence: 99%

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Patient-specific finite element modeling of scoliotic curve progression using region-specific stress-modulated vertebral growth

2023

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Purpose This study describes the creation of patient-specific (PS) osteo-ligamentous finite element (FE) models of the spine, ribcage, and pelvis, simulation of up to three years of region-specific, stress-modulated growth, and validation of simulated curve progression with patient clinical angle measurements. Research Question: Does the inclusion of region-specific, stress-modulated vertebral growth, in addition to scaling based on age, weight, skeletal maturity, and spine flexibility allow for clinically accurate scoliotic curve progression prediction in patient-specific FE models of the spine, ribcage, and pelvis? Methods Frontal, lateral, and lateral bending X-Rays of five AIS patients were obtained for approximately three-year timespans. PS-FE models were generated by morphing a normative template FE model with landmark points obtained from patient X-rays at the initial X-ray timepoint. Vertebral growth behavior and response to stress, as well as model material properties were made patient-specific based on several prognostic factors. Spine curvature angles from the PS–FE models were compared to the corresponding X-ray measurements. Results Average FE model errors were 6.3 ± 4.6°, 12.2 ± 6.6°, 8.9 ± 7.7°, and 5.3 ± 3.4° for thoracic Cobb, lumbar Cobb, kyphosis, and lordosis angles, respectively. Average error in prediction of vertebral wedging at the apex and adjacent levels was 3.2 ± 2.2°. Vertebral column stress ranged from 0.11 MPa in tension to 0.79 MPa in compression. Conclusion Integration of region-specific stress-modulated growth, as well as adjustment of growth and material properties based on patient-specific data yielded clinically useful prediction accuracy while maintaining physiological stress magnitudes. This framework can be further developed for PS surgical simulation.

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Section: Methodsmentioning

confidence: 99%

Section: Assignment Of Patient Age-and Level-specific Materials Prope...mentioning

confidence: 99%

Patient-specific finite element modeling of scoliotic curve progression using region-specific stress-modulated vertebral growth

2023

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“…Detailed T-spine models with proper verifications and validations (V&V) using experimental studies are relatively rare, especially for impact scenarios. Aira et al (2019) developed and validated a simplistic T-spine model using quasi-static loading for adjacent vertebrae and rear hub impact for chest force-deflection response. However, it did not include the stateof-the-art modeling techniques and injury-predictive capabilities that have been used in C-spines models (Panzer et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Validation of Thorax Model Responses: A Hierarchical Approach to Achieve High Biofidelity for Thoracic Musculoskeletal System

Mukherjee

Caudillo

Forman

et al. 2021

Front. Bioeng. Biotechnol.

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As one of the most frequently occurring injuries, thoracic trauma is a significant public health burden occurring in road traffic crashes, sports accidents, and military events. The biomechanics of the human thorax under impact loading can be investigated by computational finite element (FE) models, which are capable of predicting complex thoracic responses and injury outcomes quantitatively. One of the key challenges for developing a biofidelic FE model involves model evaluation and validation. In this work, the biofidelity of a mid-sized male thorax model has been evaluated and enhanced by a multi-level, hierarchical strategy of validation, focusing on injury characteristics, and model improvement of the thoracic musculoskeletal system. At the component level, the biomechanical responses of several major thoracic load-bearing structures were validated against different relevant experimental cases in the literature, including the thoracic intervertebral joints, costovertebral joints, clavicle, sternum, and costal cartilages. As an example, the thoracic spine was improved by accurate representation of the components, material properties, and ligament failure features at tissue level then validated based on the quasi-static response at the segment level, flexion bending response at the functional spinal unit level, and extension angle of the whole thoracic spine. At ribcage and full thorax levels, the thorax model with validated bony components was evaluated by a series of experimental testing cases. The validation responses were rated above 0.76, as assessed by the CORA evaluation system, indicating the model exhibited overall good biofidelity. At both component and full thorax levels, the model showed good computational stability, and reasonable agreement with the experimental data both qualitatively and quantitatively. It is expected that our validated thorax model can predict thorax behavior with high biofidelity to assess injury risk and investigate injury mechanisms of the thoracic musculoskeletal system in various impact scenarios. The relevant validation cases established in this study shall be directly used for future evaluation of other thorax models, and the validation approach and process presented here may provide an insightful framework toward multi-level validating of human body models.

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Preliminary validation of the GHBMC average male occupant models and 70YO aged model in far-side impact

Koya,

Devane,

Fuentes

et al. 2023

Accident Analysis & Prevention

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Validated thoracic vertebrae and costovertebral joints increase biofidelity of a human body model in hub impacts

Cited by 10 publications

References 20 publications

Patient-specific finite element modeling of scoliotic curve progression using region-specific stress-modulated vertebral growth

Patient-specific finite element modeling of scoliotic curve progression using region-specific stress-modulated vertebral growth

Evaluation and Validation of Thorax Model Responses: A Hierarchical Approach to Achieve High Biofidelity for Thoracic Musculoskeletal System

Preliminary validation of the GHBMC average male occupant models and 70YO aged model in far-side impact

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