Validating a new device for measuring tear evaporation rates

Rohit, Athira; Ehrmann, Klaus; Naduvilath, Thomas; Willcox, Mark; Stapleton, Fiona

doi:10.1111/opo.12096

Cited by 34 publications

(34 citation statements)

References 34 publications

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Section: Methodsmentioning

confidence: 99%

“…The VapoMeter ( http://www.delfintech.com/en/vapometer/) is a tool originally designed to measure the skin evaporation rate but that has been modified by Rohit et al . to measure evaporation from the ocular surface . The area surrounding the eye was covered with petroleum jelly (Vaseline ® , http://www.unilever.com.au/brands-in-action/detail/Vaseline/299339/) in order to minimise the influence of evaporation from the skin.…”

Section: Methodsmentioning

confidence: 99%

“…The area surrounding the eye was covered with petroleum jelly (Vaseline ® , http://www.unilever.com.au/brands-in-action/detail/Vaseline/299339/) in order to minimise the influence of evaporation from the skin. Three readings were taken for both open eyes, and closed eyes and the final evaporation rate calculated as described by Rohit et al …”

Section: Methodsmentioning

confidence: 99%

“…The VapoMeter (http://www.delfintech.com/en/vapometer/ ) is a tool originally designed to measure the skin evaporation rate but that has been modified by Rohit et al 38 to measure evaporation from the ocular surface. 38 The area surrounding the eye was covered with petroleum jelly (Vaseline â , www.unilever.com.au/brands-in-action/detail/ Vaseline/299339/) in order to minimise the influence of evaporation from the skin. Three readings were taken for both open eyes, and closed eyes and the final evaporation rate calculated as described by Rohit et al 38 In this study, an air dehumidifier was used in the measurement room to control in the ambient humidity (45.5 AE 9) and temperature (23 AE 1.5°C)…”

Section: Tear Evaporationmentioning

confidence: 99%

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Impact of duration of contact lens wear on the structure and function of the meibomian glands

Alghamdi

Markoulli

Holden

et al. 2016

Ophthalmic Physiologic Optic

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A total of 100 participants (49 males and 51 females; mean age ± SD: 25.4 ± 4.1) were enrolled across the five groups, such that each was composed of 20 age/sex matched individuals. Significant differences between the study groups were found for MG expressibility (p < 0.001), number of plugged orifices (p = 0.001), number of expressed orifices (p < 0.001), MG dropout (p = 0.001), Marx line score (p < 0.001), palpebral redness (p = 0.003), and roughness (p = 0.002), non-invasive break-up time (p < 0.001), Phenol red thread (p = 0.005), and tear meniscus area (p = 0.029). For all these variables, the NW group was statistically different from all other groups. Duration of wear was not a significant factor, except for Marx line score which was different in PWs compared to those with longer experience of CL wear (p = 0.03) CONCLUSION: Alterations to MG morphology and function accompany contact lens wear. Although these changes onset during the first 2 years of wear, prolonged CL exposure beyond this point does not appear to be associated with further modification. Cessation of wear for at up to 6 months does not lead to resolution.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Tear Evaporationmentioning

confidence: 99%

See 2 more Smart Citations

Impact of duration of contact lens wear on the structure and function of the meibomian glands

Alghamdi

Markoulli

Holden

et al. 2016

Ophthalmic Physiologic Optic

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show abstract

“…Currently there is no commercially available instrument dedicated to detection of tear film evaporation. Thus, researchers have either used in-house designed systems or modifications of closed chamber dermatological units [25,158,239]. …”

Section: Biophysical Measurements Of the Tear Filmmentioning

confidence: 99%

TFOS DEWS II Tear Film Report

et al. 2017

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The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership.

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Dry Eye Disease Associated with Meibomian Gland Dysfunction: Focus on Tear Film Characteristics and the Therapeutic Landscape

Sheppard

Nichols

2023

Ophthalmol Ther

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Meibomian gland dysfunction (MGD) is highly prevalent and is the leading cause of evaporative dry eye disease (DED). MGD is characterized by a reduction in meibum secretion and/or a change in meibum composition that results in the disruption of the tear film lipid layer and an increase in the tear film evaporation rate. Excessive evaporation causes tear film instability, desiccation, tear hyperosmolarity, inflammation, and apoptosis of ocular surface cells, resulting in a continuous cycle of DED. The primary treatment goal for DED associated with MGD is to restore the tear film lipid layer and decrease evaporation, thereby reducing ocular signs and symptoms. The management of MGD includes home care options (eyelid hygiene, warming eye masks, ocular lubricants) and office-based treatments (manual expression, microblepharoexfoliation, thermal pulsation, intense pulsed light, intraductal probing).Topical ophthalmic prescription medications attempt to alter various factors that may contribute to DED (e.g., inflammation, bacterial growth, inadequate tear production). In this review, clinical evidence regarding available treatments and emerging therapies from randomized studies in patients with DED associated with MGD is summarized. Although some treatment modalities have been evaluated specifically for DED patients with MGD, largescale randomized controlled trials are needed to confirm efficacy and safety in this patient population. Currently, there are no approved prescription pharmacologic treatments specifically indicated for DED associated with MGD, and those medications approved for the treatment of DED do not target the key driver of the disease (i.e., excessive evaporation). NOV03 (perfluorohexyloctane; under review with the US Food and Drug Administration) is the most advanced emerging therapy for DED associated with MGD and has demonstrated statistically significant improvements in both signs and symptoms in randomized controlled trials. Development of novel pharmacotherapies will improve therapeutic options and allow for a more individualized approach for patients with DED associated with MGD.

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Validating a new device for measuring tear evaporation rates

Abstract: Tear evaporation rates can be measured using a modified dermatology instrument. Measurements were higher and more variable with lens wear consistent with previous literature. Control of environmental conditions is important as a higher humidity results in a reduced evaporation rate.

Cited by 34 publications

References 34 publications

Impact of duration of contact lens wear on the structure and function of the meibomian glands

Impact of duration of contact lens wear on the structure and function of the meibomian glands

TFOS DEWS II Tear Film Report

Dry Eye Disease Associated with Meibomian Gland Dysfunction: Focus on Tear Film Characteristics and the Therapeutic Landscape

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