Validating interfacial behaviour of surface-active ionic liquids (SAILs) with computational study integrated with biocidal and cytotoxic assessment

Dani, U.; Bahadur, Anita; Kuperkar, Ketan

doi:10.1016/j.ecoenv.2019.109784

Cited by 21 publications

(9 citation statements)

References 36 publications

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“…Other applications of SAILs can be listed as foaming and antifoaming agents, antimicrobials, demulsification of crude oil, chromatographic and electrophoretic separations, enhanced oil recovery (EOR), solubilization of drugs, extraction of natural products etc. (Shah et al, 2018a , 2020 ; Vaid et al, 2018a , b ; Dani et al, 2019 ; Isosaari et al, 2019 ; Kuddushi et al, 2019 , 2020 ; Shakeel et al, 2019 ; Lee et al, 2020 ; Nandwani et al, 2020 ; El Seoud et al, 2021 ). SAILs can be of different kinds based upon their structure.…”

Section: Introductionmentioning

confidence: 99%

Scrutinizing Self-Assembly, Surface Activity and Aggregation Behavior of Mixtures of Imidazolium Based Ionic Liquids and Surfactants: A Comprehensive Review

Kumar

Kaur

2021

Front. Chem.

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The desire of improving various processes like enhanced oil recovery (EOR), water treatment technologies, biomass extraction, organic synthesis, carbon capture etc. in which conventional surfactants have been traditionally utilized; prompted various researchers to explore the self-assembly and aggregation behavior of different kinds of surface-active molecules. Ionic liquids (ILs) with long alkyl chain present in their structure constitute the advantageous properties of surfactant and ILs, hence termed as surface-active ionic liquids (SAILs). The addition of ILs and SAILs significantly influence the surface-activity and aggregation behavior of industrially useful conventional surfactants. After a brief review of ILs, SAILs and surfactants, the prime focus is made on analyzing the self-assembly of SAILs and the mixed micellization behavior of conventional surfactants with different ILs.

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Section: Introductionmentioning

confidence: 99%

Scrutinizing Self-Assembly, Surface Activity and Aggregation Behavior of Mixtures of Imidazolium Based Ionic Liquids and Surfactants: A Comprehensive Review

Kumar

Kaur

2021

Front. Chem.

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“…They are considered “green solvents” since their liquid state is not due to the presence of a solvent but rather due to the combination of a cation and anion, which determine the ILs’ polar and hydrophobic properties. , Properties such as viscosity, , melting temperature below room temperature, and high surface activity are relevant for developing biomedical applications. Nevertheless, the high surface activity may be the reason for the cytotoxicity of some ILs toward biological systems. ,, While this is a concern for eukaryotic cells, it has been considered an interesting and important property in microbiology . ILs have been reported to have the ability to interact with microbial cell walls in a mechanism that involves their aggregation into the membrane components, disrupting the cell membrane integrity and showing their potential in antimicrobial applications. − Moreover, ILs present specific chemical structures, which could be used for modifying the structure of antimicrobial agents/antibiotics to synergistically increase their efficacy through the introduction of tailored ILs’ cations or anions.…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquids as Biocompatible Antibacterial Agents: A Case Study on Structure-Related Bioactivity on Escherichia coli

Fernandes

Carvalho

Correia

et al. 2022

ACS Appl. Bio Mater.

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The potential of ionic liquids (ILs) to be used as antimicrobial agents for biomedical applications has been hindered by the fact that most of them are cytotoxic toward mammalian cells. Understanding the mechanism of bacterial and mammalian cellular damage of ILs is key to their safety design. In this work, we evaluate the antimicrobial activity and mode of action of several ILs with varying anions and cations toward the clinically relevant Gram-negative Escherichia coli. Langmuir monolayer technique was used to evaluate if the IL’s mode of action was related to the bacterial cell membrane interaction for an effective E. coli killing. 1-Decyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide [DMIM][TFSI] and trihexyltetradecyl phosphonium bis(trifluoromethylsulfonyl) imide [P6,6,6,14][TFSI] were surface-active and induced bacterial cell lysis, through a membrane-disruption phenomenon on bacteria, in a mechanism that was clearly related to the long alkyl chains of the cation. 1-Ethyl-3-methylimidazolium hydrogen sulfate [EMIM][HSO4] was highly antimicrobial toward E. coli and found suitable for biological applications since it was harmless to mammalian cells at most of the tested concentrations. The results suggest that the imidazolium cation of the ILs is mostly responsible not only for their antimicrobial activity but also for their cytotoxicity, and the inclusion of different anions may tailor the ILs’ biocompatibility without losing the capacity to kill bacteria, as is the case of [EMIM][HSO4]. Importantly, this IL was found to be highly antimicrobial even when incorporated in a polymeric matrix.

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“…ILs are considered non-toxic for manipulation since the ILs liquid state is not due to the presence of a solvent but rather due to the properties resulting from the specific combination of cations and anions. This fact, together with their tunability of polar/apolar moieties, leads to them being considered as solvents suitable for “green chemistry” applications [ 16 , 17 ]. Nevertheless, and despite being considered a green solvent, their long-term toxicity for biological systems, as well as their poor biodegradability are still a focus of concern [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…This fact, together with their tunability of polar/apolar moieties, leads to them being considered as solvents suitable for “green chemistry” applications [ 16 , 17 ]. Nevertheless, and despite being considered a green solvent, their long-term toxicity for biological systems, as well as their poor biodegradability are still a focus of concern [ 17 ]. Novel strategies for overcoming these issues are being developed.…”

Section: Introductionmentioning

confidence: 99%

Ionic Liquid-Based Materials for Biomedical Applications

Correia

Fernandes

et al. 2021

Nanomaterials

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Ionic liquids (ILs) have been extensively explored and implemented in different areas, ranging from sensors and actuators to the biomedical field. The increasing attention devoted to ILs centers on their unique properties and possible combination of different cations and anions, allowing the development of materials with specific functionalities and requirements for applications. Particularly for biomedical applications, ILs have been used for biomaterials preparation, improving dissolution and processability, and have been combined with natural and synthetic polymer matrixes to develop IL-polymer hybrid materials to be employed in different fields of the biomedical area. This review focus on recent advances concerning the role of ILs in the development of biomaterials and their combination with natural and synthetic polymers for different biomedical areas, including drug delivery, cancer therapy, tissue engineering, antimicrobial and antifungal agents, and biosensing.

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Validating interfacial behaviour of surface-active ionic liquids (SAILs) with computational study integrated with biocidal and cytotoxic assessment

Cited by 21 publications

References 36 publications

Scrutinizing Self-Assembly, Surface Activity and Aggregation Behavior of Mixtures of Imidazolium Based Ionic Liquids and Surfactants: A Comprehensive Review

Scrutinizing Self-Assembly, Surface Activity and Aggregation Behavior of Mixtures of Imidazolium Based Ionic Liquids and Surfactants: A Comprehensive Review

Ionic Liquids as Biocompatible Antibacterial Agents: A Case Study on Structure-Related Bioactivity on Escherichia coli

Ionic Liquid-Based Materials for Biomedical Applications

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